Victors

C13R
Victor ID	5100
Gene Name	C13R
Sequence Strain (Species/Organism)	Ectromelia virus
NCBI Gene ID	951519
NCBI Protein GI	22164602
Locus Tag	ECTVgp168
Genbank Accession	AF012825
Protein Accession	NP_671686
Taxonomy ID	12643
Gene Starting Position	191521
Gene Ending Position	193200
Gene Strand (Orientation)	+
Protein Name	hypothetical protein
Protein pI	5.67
Protein Weight	61320.91
Protein Length	559
Protein Note	Also known as EVM167hypothetical protein; similar to vaccinia virus strain Copenhagen C2L, variola major virus strain Bangladesh B19R and cowpox virus B19R; the poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins
DNA Sequence	>gi\|22164589:191521-193200 Ectromelia virus, complete genome GATGGATATTGATGATATTAAACATAATAGACGAGTAGTAAGTAACATTAGCAGTCTTTTAGACAATGAT ATATTATGTGATGTAATTATAACTATTGGAGATGGAGAAGAAATTAAAGCGCATAAAACTATATTGGCTG CCGGATCTAAATATTTTAGAACACTGTTTACAACACCTATGATAATAAGAGATCTAGTAACTAGAGTAAA TCTACAGATGTTCGATAAAGATGCTGTCAAAAATATTGTACAATACTTATACAATAGGCATATAAGTTCT ATGAATGTAATAGACGTATTAAAATGCGCCGACTATCTTCTAATCGATGATCTAGTAACTGACTGTGAAT CTTATGTTAAGGATTATACTAATCATGATACCTGTATATATATTTATCATAGGTTGTATGAGATGTCTCA TATTCCAATAGTCAAATATGTTAAACGTATGGTGATGCGTAATATACCAACATTGATAACTACGGATGCA TTTAAAAACGCAGTATTCGAAATATTACTCGATATTATTTCTACCAACGATGGTGAGTATGTATACAGAG AAGGATATAAAGTGACGATACTATTGAAGTGGCTAGATTACAACTACATCACTGAAGAACAGCTGTTGTG TATACTGTCCTGTATAGATATACAAAATCTAGATAAGAAATCTAGACTACTACTCTATTCGAATACAACT ATAAATATGTATTCTTCGTGTGTGAAATTTCTATTAGACAATAAACAGAATAGAAACATTATACCCCGTC AGTTATGTTTAGTATATCATGATACTAACTACAATATAAGTAACCCATGTATATTAGTATATAATATTAA TACTATGGAATACAATACCATTTACACCATTCATAATAACATAATTAATTACTCATCAGCTGTTGTCGAT AATGAAATAATAATAGCTGGAGGATATAACTTTAACAATATATCATTGAACAAGGTATATAAAATAAATA TCGAACACAGAACATGTGTAGAACTCCCACCCATGATAAAGAATAGATGTCATTTTTCACTGGCTGTAAT CGATGACATGATTTATGCTATAGGTGGTCAAAACGGTACAATAGTGGAACGAAGCGTAGAATGTTATACA ATGGGCGATGATACGTGGAAGATGTTACCTGATATGCCCGATGCAATATCGAGCTACGGCATGTGTGTAT TCGATCAATACATATACATTATAGGTGGTCGTACAGAACACGTCAAATATATACCTGTACAACACATGAA TGAAATAGTAGATATAAACGAACATTCTTCAGATAAAGTTATACGATACGACACTGTCAATAATATATGG GAGAAGTTACCGAACTTATGTAGTGGAACCATAAGACCAAGCGTTGTTTCACATAAAGATGATATATATG TTGTATGTGACATCAAAGATGATGAAATAAATGGTTTTAAGACTTGTATATTTAGATATAACACGAAGGA TAATTATAAAGGATGGGAATTGATAACGACTATAGACAGTAAATTAACCGTTTTACATACTATTCTTCAC GACGATGCCATAACGATACTACATTGGTATGAATCGTGTATGATACAAGATAAATTTAATATCGACACCT ACAAATGGACTAATATATGTTATCAACGTTCGAATAGTTATATAGTACACGATACACTACCCATCTACTA
Protein Sequence	>gi\|22164602\|ref\|NP_671686.1\| C13R [Ectromelia virus] MDIDDIKHNRRVVSNISSLLDNDILCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVN LQMFDKDAVKNIVQYLYNRHISSMNVIDVLKCADYLLIDDLVTDCESYVKDYTNHDTCIYIYHRLYEMSH IPIVKYVKRMVMRNIPTLITTDAFKNAVFEILLDIISTNDGEYVYREGYKVTILLKWLDYNYITEEQLLC ILSCIDIQNLDKKSRLLLYSNTTINMYSSCVKFLLDNKQNRNIIPRQLCLVYHDTNYNISNPCILVYNIN TMEYNTIYTIHNNIINYSSAVVDNEIIIAGGYNFNNISLNKVYKINIEHRTCVELPPMIKNRCHFSLAVI DDMIYAIGGQNGTIVERSVECYTMGDDTWKMLPDMPDAISSYGMCVFDQYIYIIGGRTEHVKYIPVQHMN EIVDINEHSSDKVIRYDTVNNIWEKLPNLCSGTIRPSVVSHKDDIYVVCDIKDDEINGFKTCIFRYNTKD NYKGWELITTIDSKLTVLHTILHDDAITILHWYESCMIQDKFNIDTYKWTNICYQRSNSYIVHDTLPIY
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: deletions of one to four genes of kelch family both individually (single mutants) and in different combinations (double, triple and quadruple mutants). It was shown that deletion of any of the three genes EVMO18, EVM027 or EVM167 resulted in reduction of 50% lethal dose (LD50) by five and more orders in outbred white mice infected intraperitoneally. Deletion of mousepox kelch-gene EVM150 did not influence the virus virulence. Two or more kelch-genes deletion also resulted in high level of attenuation, which could evidently be due to the lack of three genes EVM167, EVM018 and/or EVM027 identified as virulence factors. (Kochneva et al., 2009)
References	*Kochneva et al., 2009:* Kochneva GV, Kolosova IV, Lupan TA, Sivolobova GF, Iudin PV, Grazhdantseva AA, Riabchikova EI, Kandrina NIu, Shchelkunov SN. [Orthopoxvirus genes for kelch-like proteins. III. Construction of mousepox (ectromelia) virus variants with targeted gene deletions]. Molekuliarnaia biologiia. 2009; 43(4); 616-622. [PubMed: 19807023].


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C13R