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SPPV_19

Victor ID 5093
Gene Name SPPV_19
Sequence Strain (Species/Organism) Sheeppox virus
NCBI Gene ID 944630
NCBI Protein GI 21492476
Locus Tag SPPV_19
Protein Accession NP_659595
Taxonomy ID 10266
Gene Starting Position 14836
Gene Ending Position 15147
Gene Strand (Orientation) -
Protein Name hypothetical protein
Protein pI 9.61
Protein Weight 11312.88
Protein Length 103
Protein Note hypothetical protein; The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins
DNA Sequence 
>gi|21426071:14836-15147 Sheeppox virus 17077-99, complete genome
TTTATATAAATACATCATCATTTGAAACACTGTCGTCATAATTTATGTAATACATTACTTTATGAGGTGT
CTTTCTTTTTGTAATTTTATACTTGTAGTTATAATTATATTTAGAATCATTATCATCACTACTAACGGTA
TTATCACTATCATTAGCACCATCACTATCTAACAGTGTAACACGGTCGATAGATATTGCCTTTTTCATAT
TGCTTTTCCTTATAAAACTAACACATTTAATAGCCTTTTCTTTTATACTTTTTTTAAATAATTTATAACC
AAATACTATACCACAATAATTTTTTTTATCCA
Protein Sequence 
>gi|21492476|ref|NP_659595.1| hypothetical protein SPPV_19 [Sheeppox virus]
MDKKNYCGIVFGYKLFKKSIKEKAIKCVSFIRKSNMKKAISIDRVTLLDSDGANDSDNTVSSDDNDSKYN
YNYKYKITKRKTPHKVMYYINYDDSVSNDDVFI
Molecule Role Virulence factor
Molecule Role Annotation When inoculated in sheep by the intranasal or intradermal routes, DeltaKLP was markedly attenuated, since all DeltaKLP-infected lambs survived infection. In contrast, SPPV-SA and RvKLP induced mortality approaching 100%. (Balinsky et al., 2007)
References
Balinsky et al., 2007: Balinsky CA, Delhon G, Afonso CL, Risatti GR, Borca MV, French RA, Tulman ER, Geary SJ, Rock DL. Sheeppox virus kelch-like gene SPPV-019 affects virus virulence. Journal of virology. 2007; 81(20); 11392-11401. [PubMed: 17686843].