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VP2

Victor ID 5092
Gene Name VP2
NCBI Protein GI 6863044
Other Database IDs CDD:251643
Taxonomy ID 12618
Gene Strand (Orientation) ?
Protein Name VP2
Protein Length 216
Protein Note TT viral ORF2; pfam02957
Protein Sequence 
>gi|6863044|dbj|BAA90489.1| VP2 [Chicken anemia virus]
MHGNGGQPAAGGSESALSREGQPGPSGAAQGQVISNERSPRRYSTRTINGVQATNKFTAVGNPSLQRDPD
WYRWNYNHSIAVWLRECSRSHAKICNCGQFRKHWFQECAGLEDRSTQASLEEAILRPLRVQGKRAKRKLD
YHYSQPTPNRKKVYKTVRWQDELADREADFTPSEEDGGTTSSDFDEDINFDIGGDSGIVDELLGRPFTTP
APVRIV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Relative to wild-type infection, viruses Mut C86R, Mut R101G, Mut H103Y, Mut R129G, Mut Q131P, Mut R/K/K150/151/152G/A/A, Mut D/E161/162G/G and Mut E186G were highly attenuated, and viruses Mut L163P and Mut D169G were moderately attenuated. These findings show that mutations in the VP2 gene can reduce the virulence of CAV and these mutant viruses may have value as vaccine candidates (Peters et al., 2007).
References
Peters et al., 2007: Peters MA, Crabb BS, Tivendale KA, Browning GF. Attenuation of chicken anemia virus by site-directed mutagenesis of VP2. The Journal of general virology. 2007; 88(Pt 8); 2168-2175. [PubMed: 17622619].