Victors

G gene
Victor ID	5091
Gene Name	G gene
NCBI Nucleotide GI	46310179
NCBI Protein GI	46310180
Protein Accession	AAS87364.1
Taxonomy ID	270473
Gene Strand (Orientation)	?
Protein Name	attachment G protein
Protein Length	396
DNA Sequence	>gi\|46310179\|gb\|AY573817.1\| Pneumonia virus of mice J3666 attachment G protein mRNA, complete cds ATGGGAAGGAACTTTGAAGTGAGTGGCAGCATTACTAATTTGAACTTTGAGAGAACTCAGCATCCTGACA CATTTAGGACTGGTGTAAAAGTGAACCAAATGTGTAAGCTTATTGCAGGTGTGCTCACAAGTGCTGCTGT GGCAGTTTGTGTGGGGGTCATAATGTATTCTGTTTTCACATCAAACCACAAGGCCAACTCCACGCAGAAT GCCACGACCCGGAACAGCACATCCACCCCTCCCCAACCAACCGCCGGTCTGCCCACCACAGAGCAAGGGA CCATCCCCAGATTCACCAAACCCCCCACCAAAACCGCCACCCACCATGAGATCACAGAGCCCGTCAAAAT GGCAACACCTTCAGAGGATCCCTACCAATGCTCCAGCAATGGTTATTTGGACCGACCTGATTTACCTGAA AATTTCAAACTCGTATTGGATGTTATATGCAAGCCTCCAGGTCCTGAACATCACAACACCAGCTGTTATG AGAAACGTGAAATCAACCCAGGAAGTGTTTGCCCTGATCTTGTAACAATGAAGGCAAACATGGGCTTAAA CAATGGTGGTGGGGAGGATGCTGCACCTTATATAGAGGTTACCACCCTTTCTACGTACTCCAACAAAAGG GCAATGTGTGTCCACAATGGGTGTGATCAAGGCTTCTGTTTCTTCCTTTCTGGTTTAAGCACTGATCAGG AGAGAGCTGTGCTAGAGCTTGGAGGTCAACAGGCTATCATGGAGTTGCATTATGATTCCTACTGGAAACA CTATTGGAGTAACTCTAATTGTGTTGTTCCCAGAACAAACTGCAACCTGACAGACCAAACTGAGATTTTG TTTCCTAGGTTTAACAACAAGAATCAGTCTCAGTGTACCACCTGTGCAGATTCAGCTGGCCTAGATAACA AATTTTATCTCACATGTGATGGGCTCTTAAGAACCCTCCCTCTAGTTGGACTACCCAGCCTAAGTCCTCA GGCTTACAAAGCTGTACCCACACAAACTACAGGCACCACCACGGCACCAACATCAGAGTCGAGGCACCCA ACCCCTGCACCCAGGAGGTCCAAACCTCTCAGTCGGAAGAAGAGAGCTTTATGTGGTGTAGACTCAGGCA GAGAACCCAAACCAACAATGCCTTACTGGTGTCCTATGCTCCAATTATTTCCAAGGAGGTCTAATTCTTA A
Protein Sequence	>gi\|46310180\|gb\|AAS87364.1\| attachment G protein [Pneumonia virus of mice J3666] MGRNFEVSGSITNLNFERTQHPDTFRTGVKVNQMCKLIAGVLTSAAVAVCVGVIMYSVFTSNHKANSTQN ATTRNSTSTPPQPTAGLPTTEQGTIPRFTKPPTKTATHHEITEPVKMATPSEDPYQCSSNGYLDRPDLPE NFKLVLDVICKPPGPEHHNTSCYEKREINPGSVCPDLVTMKANMGLNNGGGEDAAPYIEVTTLSTYSNKR AMCVHNGCDQGFCFFLSGLSTDQERAVLELGGQQAIMELHYDSYWKHYWSNSNCVVPRTNCNLTDQTEIL FPRFNNKNQSQCTTCADSAGLDNKFYLTCDGLLRTLPLVGLPSLSPQAYKAVPTQTTGTTTAPTSESRHP TPAPRRSKPLSRKKRALCGVDSGREPKPTMPYWCPMLQLFPRRSNS
Molecule Role	Virulence factor
Molecule Role Annotation	As a first step, we evaluated recombinant mutants bearing a deletion of the entire G gene (Delta G) or expressing a G protein lacking its cytoplasmic tail (Gt). Both G mutants replicated as efficiently in vitro as their recombinant parent, but both were nonpathogenic in mice at doses that would otherwise be lethal. We could not detect replication of the Delta G mutant in mice, indicating that its attenuation is based on a severe reduction in the virus load. (Krempl et al., 2007)
References	*Krempl et al., 2007:* Krempl CD, Wnekowicz A, Lamirande EW, Nayebagha G, Collins PL, Buchholz UJ. Identification of a novel virulence factor in recombinant pneumonia virus of mice. Journal of virology. 2007; 81(17); 9490-9501. [PubMed: 17567693].


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G gene