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UL47

Victor ID 5086
Gene Name UL47
NCBI Protein GI 1486489
Other Database IDs CDD:251899
Taxonomy ID 10386
Gene Strand (Orientation) ?
Protein Name UL47
Protein Length 623
Protein Note Herpesvirus UL47 protein; pfam03362
Protein Sequence 
>gi|1486489|gb|AAC55097.1| UL47 [Gallid herpesvirus 1]
MTLPHRLTKRPFARRFCSVFVIHYSETKLDRYNKTMLLYRPDSTMRHSGGDANHRGIRPRRKSIGAFSAR
EKTGKRNALTESSSSSDMLDPFSTDKEFGGKWTVDGPADITAEVLSQAWDVLQLVKHEDAEEERVTYESK
PTPIQPFNAWPDGPSWNAQDFTRAPIVYPSAEVLDAEALKVGAFVSRVLQCVPFTRSKKSVTVRDAQSFL
GDSFWRIMQNVYTVVLRQHITRLRHPSSKSIVNCNDPLWYAYANQFHWRGMRVPSLKLASPPEENIQHGP
MAAVFRNAGAGLFLWPAMRAAFEERDKRLLRACLSSLDIMDAAVLASFPFYWRGVQDTSRFEPALGCLSE
YFALVVLLAETVLATMFDHALVFMRALADGNFDDYDETRYIDPVKNEYLNGAEGTLLRGIVASNTALAVV
CANTYSTIRKLPSVATSACNVAYRTETLKARRPGMSDIYRILQKEFFFYIAWLQRVATHANFCLNILKRS
VDTGAPPFLFRASSEKRLQQLNKMLCPLLVPIQYEDFSKAMGSELKREKLETFVKAISSDRDPRGSLRFL
ISDHAREIIADGVRFKPVIDEPVRASVALSTAAAGKVKARRLTSVRAPVPGAGAVSARRKSEI
Molecule Role Virulence factor
Molecule Role Annotation Experimental infection of chickens demonstrated that UL47-negative ILTV was significantly attenuated in vivo and was shed in reduced amounts, whereas wild-type and rescued viruses caused severe disease and high mortality rates. As all immunized animals were protected against subsequent challenge infection with virulent ILTV, the UL47 deletion mutant might be suitable as a live-virus vaccine. (Helferich et al., 2007)
References
Helferich et al., 2007: Helferich D, Veits J, Teifke JP, Mettenleiter TC, Fuchs W. The UL47 gene of avian infectious laryngotracheitis virus is not essential for in vitro replication but is relevant for virulence in chickens. The Journal of general virology. 2007; 88(Pt 3); 732-742. [PubMed: 17325345].