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m128L

Victor ID 5084
Gene Name m128L
Sequence Strain (Species/Organism) Myxoma virus
NCBI Gene ID 932066
NCBI Protein GI 9633764
Locus Tag MYXV_gp132
Genbank Accession JX565583
Protein Accession NP_051842
Taxonomy ID 10273
Gene Starting Position 121055
Gene Ending Position 121900
Gene Strand (Orientation) -
Protein Name mRNA
Protein pI 7.01
Protein Weight 29901.73
Protein Length 281
DNA Sequence 
>gi|18450236:121055-121900 Myxoma virus, complete genome
ATTATAGAAACGTGAAGGTTTCGTCCGATTGGAGGTATAACTTTTTATACGTCGCCTGAGTGCCCAAGGG
TAGCGTGTACAACGCGATTAAACTAATTAACTCTAATATATCCGCGAACAAGAGTTTATACATGTATGTG
TACCCGTACGCTTTATTGTAACATCCGATGAAGGATAACGCGATAACGACCGTAGACCCCGTATACGAGA
CGGCCTTCAACCCCAAAACGATATTTAGTAAGTACGAAGGTATTAGTTTTTTGTGAAGAATACGCTGTAA
GAAAATTGATGAGAAAATAGACAGCTGAATAAGAATGATTCCGTTTACCTTTACGTATAACATATCCGTA
TCTATACCGATCATATACTGTCCTACGAACATAATAAGCGTCATCCATAAAGCGATAGAATACACGTGAA
TCAACTTGGATACGTTGTTTATTTTAAACGTTATCGTACACACGTTTCCCCACAACAATATAATGTAAAT
AGTAAGTAAAGACAGAATAAACTGAATCTCTTCGCGACTAAACCATTGGTGTACGAAAGTTAGCGCGATA
ACGTGTTTCACCGAGTTGAACTCGCTATACGCCTCGCACGTGTAGTTCCCCGTCAGGTTGTTCGCGAAAT
CGAACGTGATAGACGACCCGTTCGTTTTATTCGAAATCGTATCATACATCGTGTCGAATAACCACTTTAC
GTGGACAGAATTTATATCTTTGTAAATTAACGCGTCTAGGTTACACTCCAACGTAACCGTCTTATTACAC
ACCGTGTAGGGCGTTACGGTTACTTCGTTTTCGGCGGCCAGAGGAACTACGTATACGAAGAACAATAAAC
CTATCA
Protein Sequence 
>gi|9633764|ref|NP_051842.1| m128L [Myxoma virus]
MIGLLFFVYVVPLAAENEVTVTPYTVCNKTVTLECNLDALIYKDINSVHVKWLFDTMYDTISNKTNGSSI
TFDFANNLTGNYTCEAYSEFNSVKHVIALTFVHQWFSREEIQFILSLLTIYIILLWGNVCTITFKINNVS
KLIHVYSIALWMTLIMFVGQYMIGIDTDMLYVKVNGIILIQLSIFSSIFLQRILHKKLIPSYLLNIVLGL
KAVSYTGSTVVIALSFIGCYNKAYGYTYMYKLLFADILELISLIALYTLPLGTQATYKKLYLQSDETFTF
L
Molecule Role Virulence factor
Molecule Role Annotation Creation of an M128L-deletion mutant myxoma virus strain and subsequent infection of the European rabbit demonstrated that M128L is necessary for the production of a lethal infection in susceptible rabbits, while it is fully dispensable for virus replication in vitro. Secondary sites of infection developed on the majority of rabbits infected with the M128L-deletion mutant (vMyx128KO), demonstrating that the M128L protein is nonessential for the dissemination of virus within the host. (Cameron et al., 2005)
References
Cameron et al., 2005: Cameron CM, Barrett JW, Mann M, Lucas A, McFadden G. Myxoma virus M128L is expressed as a cell surface CD47-like virulence factor that contributes to the downregulation of macrophage activation in vivo. Virology. 2005; 337(1); 55-67. [PubMed: 15914220].