Victors

pe38
Victor ID	5080
Gene Name	pe38
Sequence Strain (Species/Organism)	Bombyx mori NPV
NCBI Gene ID	1488760
NCBI Protein GI	9630952
Locus Tag	Bmnpvgp136
Genbank Accession	L33180
Protein Accession	NP_047549
Taxonomy ID	271108
Gene Starting Position	122415
Gene Ending Position	123344
Gene Strand (Orientation)	+
Protein Name	PE38
Protein pI	8.54
Protein Weight	33824.25
Protein Length	309
Protein Note	36107 Da primary translation product
DNA Sequence	>gi\|9630816:122415-123344 Bombyx mori NPV, complete genome AATGCCAAGGGACACCAACAATCGCCGCCGCCACCGGTCTACGCCATATGAACGTCCTACGCTTGAAGAT CTCCACAGACAGTTGGAAGACGCTTTGGAGAGGCGCTATCAAATGCGTAGAAGGCAGCGTCAAAACCGGC TCCGCACCATACAAATAAAACAGCAGCGAATGATGGCGGAATTAAAGAAAGAGCCGGTAATTAATTTTAA ATTTGAGTGCAGTGTGTGTTTCGAAACATATTCTCAACAATCTAACGATACTTGTCCTTTTTTGATTCCG ACTACGTGCGACCACGGTTTTTGTTTCAAATGCGTCATCGATCTGCAAAGCAACGCGATGAATATTCCAC ATTCAATTGTGTGCTGTCCATTGTGCAATACCCAGGTAAAAATGTGGCGTTCTTTAAAACCTAACGCTGT TGTGACGTGTAAGTTTTACAAGAAAACTCAAGAAAGAGTTCCGGCCGTGCAGCAATATAAAAACATTATC AAAGTGCTACAAGAACGGAGCGTGATTAGTGTCGAAAACAGCGACAACAATTGTGACATAAATATGGAGA ATCAGGCAAAAATAGTTGCTTTGGAAGCTGAATTAAAGAACGAAAAAAATCACAGTGATCAAGTAACTTC TGAAAACCGACAGCTAATAGAGGAAAATACTCGTCTCAACGAACAGGTTCAAGAATTGCAGCGTCAGGTG AGGACATTGGCGCCGCAACGTGGCATTACGGTTAATCCGCAAATAGGCCGTGACGACCGTGCGCCAGCCG AGCTGAACGAGCGTTTTCGCTCACTCGTCTATTCGACTATTTCAGAACTGTTTATTGAAAATCGCGTTCA TAGTATTCAAAATTATGTTTATGCCGGAACTTCTGGTGCTGCTAGTTCATGTGATGTAAATGTTACTGTT AATTTTGGGTTTGAAAATTA
Protein Sequence	>gi\|9630952\|ref\|NP_047549.1\| PE38 [Bombyx mori nucleopolyhedrovirus] MPRDTNNRRRHRSTPYERPTLEDLHRQLEDALERRYQMRRRQRQNRLRTIQIKQQRMMAELKKEPVINFK FECSVCFETYSQQSNDTCPFLIPTTCDHGFCFKCVIDLQSNAMNIPHSIVCCPLCNTQVKMWRSLKPNAV VTCKFYKKTQERVPAVQQYKNIIKVLQERSVISVENSDNNCDINMENQAKIVALEAELKNEKNHSDQVTS ENRQLIEENTRLNEQVQELQRQVRTLAPQRGITVNPQIGRDDRAPAELNERFRSLVYSTISELFIENRVH SIQNYVYAGTSGAASSCDVNVTVNFGFEN
Molecule Role	Virulence factor
Molecule Role Annotation	a knockout virus, Delta pe38-E9/E9, in which the pe38 open reading frame was replaced with that of the green fluorescent protein. We compared mutant and wild-type (WT) viral replication in insect cell culture and virulence in Heliothis virescens larvae. Compared to WT, Delta pe38-E9/E9 budded virus (BV) production was delayed by at least 3 h, and BV yields were reduced over 99%. Similarly, Delta pe38-E9/E9 DNA synthesis levels were greatly reduced relative to those of WT, but onset of DNA replication was the same for both viruses. In bioassays, nearly sevenfold more Delta pe38-E9/E9 virus than WT virus was required to achieve an LD(50) when administered orally, but not hemocoelically. (Milks et al., 2003)
References	*Milks et al., 2003:* Milks ML, Washburn JO, Willis LG, Volkman LE, Theilmann DA. Deletion of pe38 attenuates AcMNPV genome replication, budded virus production, and virulence in heliothis virescens. Virology. 2003; 310(2); 224-234. [PubMed: 12781710].


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pe38