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UL50

Victor ID 5079
Gene Name UL50
Sequence Strain (Species/Organism) Gallid herpesvirus 1
NCBI Gene ID 3239078
NCBI Protein GI 57790936
Locus Tag GaHV1_gp05
Genbank Accession AJ249803
Protein Accession YP_182340
Taxonomy ID 10386
Gene Starting Position 17893
Gene Ending Position 19181
Gene Strand (Orientation) -
Protein Name deoxyuridine triphosphatase
Protein pI 5.05
Protein Weight 42358.62
Protein Length 416
Protein Note 3.6.1.23
DNA Sequence 
>gi|57790931:17893-19181 Gallid herpesvirus 1, complete genome
CTTTAATAAAGTATGTTTAAATTTTCCAATGTCAGTACATTATTTGCCGGTAGATCCAAACCCCCCGTCA
CCCCGAACCGACAACGTATTGCGTTCGTCTACTACTGAGTTTACTATTTTCCAGCGAAGGGCATCTGGCT
CTCCGAGAAAGGTGCTTCTCTTCTCAGTAACTATTAGCTGTGCCACTCGGTCACCTGCGTGAATACTGGC
CGCTTCATCTCGAATGTTAGTTAGCGAAAATGATATCCAATCATTATCCTGCACATGTATCGGGTCGACT
AACAGTCCTTTCAGATTCATGGAGGATCTCCCTAGTATGAATGCGCGCCAGAAAGGTCCGCATGCTAGTT
TTTGGGGAAGGGTAATACGGGTAGACGACTTTGGAAGAATTGTTACATCTTTAGTAGCTCTAATATCATA
GCCTCCATCTCCTGGACGTTTGGGGGCAAAGATTTCGTTAAACGGAAACAGTGCGGCAGGGCAATCTGGA
TCTGATCGCAGCTCGACTGTCTGATCTTTAACGAGCGATCGTGTAGCTCCGACGATGATATGGTGTCGCA
CCTGGGCTACAAACTTGATGTTCGATGCGCCACAAAAACGATTGATATTTTCTGGCGTCGCTCCATTCAG
TATAACGATGCGTTCATTGCAGGCTGCATCTTGCTCCTGCAATTCTTCGAATGTTCTTCTGTAAAACGTT
GTACATCCCATACAACCAATGTTGCCCGGAATAGTTATTTTCGCCCTTAATATATCTGGAGGTATACTTA
AAAGGGAACTTATACATTTCTCGAAACCTTCACCCAAATAATCATCTTCGCCTTGGAAAGAATCTGCGGT
TTCTAAGAGTAGGCGCGCGTATCCCGTCCCACACTTGCTAAGCATGGAATCGTTAGCCAACTTTATAACA
TTTAGCCGAGCCCTTACAGTGCCTGGTGGAAATATAACATTTCCGTCTCTTGTCTCTGTGCCAGTCAAAA
CATTCCCGCCATCGTTTACAAGTACTACCAGTATTCCCAATAATCCTGTATAGTCTGCATCTACCAATCC
TGGAATAATTTGATAACATGCAGCATGGCCTTCCACATCACTGATAACGATTCCATACCCGACTGGCAAA
GAAGTCCTAATCGCAGAATCAATTCTTAGGACGGGAGAGTCGGTGCGTGTTTTCGCTATTGTTGCTTCAA
CGTTTGTAATGACACATTGCAAGGAATCGAGGCCAAAAATGTCCCACCCAGATCCAATCTCTATTAATGC
ATTTTTTTCCGTTGTCATTTCCATCTCCA
Protein Sequence 
>gi|57790936|ref|YP_182340.1| deoxyuridine triphosphatase [Gallid herpesvirus 1]
MEMEMTTEKNALIEIGSGWDIFGLDSLQCVITNVEATIAKTRTDSPVLRIDSAIRTSLPVGYGIVISDVE
GHAACYQIIPGLVDADYTGLLGILVVLVNDGGNVLTGTETRDGNVIFPPGTVRARLNVIKLANDSMLSKC
GTGYARLLLETADSFQGEDDYLGEGFEKCISSLLSIPPDILRAKITIPGNIGCMGCTTFYRRTFEELQEQ
DAACNERIVILNGATPENINRFCGASNIKFVAQVRHHIIVGATRSLVKDQTVELRSDPDCPAALFPFNEI
FAPKRPGDGGYDIRATKDVTILPKSSTRITLPQKLACGPFWRAFILGRSSMNLKGLLVDPIHVQDNDWIS
FSLTNIRDEAASIHAGDRVAQLIVTEKRSTFLGEPDALRWKIVNSVVDERNTLSVRGDGGFGSTGK
Molecule Role Virulence factor
Molecule Role Annotation The H5 hemagglutinin (HA) gene of a highly pathogenic avian influenza virus (AIV) isolate (A/chicken/Italy/8/98) was cloned and sequenced, and inserted at the non-essential UL50 (dUTPase) gene locus of a virulent strain of infectious laryngotracheitis virus (ILTV). In vitro replication of the HA-expressing ILTV mutants was not affected, and infection of chickens revealed a reduced but still considerable virulence, similar to that of a UL50 gene deletion mutant without foreign gene insertion. Thus, although attenuation remains to be improved, genetically engineered ILTV live-virus vaccines might be used as vectors to protect chickens also against other pathogens. (Lüschow et al., 2001)
References
Lüschow et al., 2001: Lüschow D, Werner O, Mettenleiter TC, Fuchs W. Protection of chickens from lethal avian influenza A virus infection by live-virus vaccination with infectious laryngotracheitis virus recombinants expressing the hemagglutinin (H5) gene. Vaccine. 2001; 19(30); 4249-4259. [PubMed: 11457552].