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pV

Victor ID 5078
Gene Name pV
NCBI Nucleotide GI 219964716
NCBI Protein GI 219964717
Protein Accession ACL68410.1
Other Database IDs CDD:206481
CDD:205189
Taxonomy ID 11176
Gene Strand (Orientation) ?
Protein Name V protein
Protein Length 239
Protein Note N-terminal region of Paramyxovirinae phosphoprotein (P); pfam14313
DNA Sequence 
>gi|219964716|gb|FJ534731.1| Newcastle disease virus strain Kr-102/89 V protein (V) gene, complete cds
ATGGCCACCTTTACAGATGCTGAGATAGACGATATATTTGAGACCAGTGGAACTGTCATTGACAGCATAA
TCACGGCCCAGGGTAAATCAGTAGAGACTGTCGGGAGGAGCGCAATCCCTCAAGGCAAGACCAAAGCCCT
GAGCACAGCGTGGGAGAAGCATGGGAACATCCAGTCATCCGCTGGCCAGGACGCCTCTGACCAACAGGAT
AGGCCAGACAAACAGCCATCCACACCCGAGCAGGCAACCCCACACAACGACCCGCCAGCCACATCTAACG
AACCGCTTCCCACTCAGGCCGCAGGTGAGGCCGGCGACACACAGCTCAAGACCGGAGCAAGCAACTCTCT
TCTGTCCATGCTTGACAAGCTGAGCAATAAATCGTCTAATGCTAAAAAGGGGGCCACGGTCGAGCCCCCA
AGAGGGCCATCATCAACCTCCGGCCCAACAACATGGGAATCAGCCGGGCCGTGGAAACAACCAGGAAAGA
CTGCAACACCAGGTCAAGGCCGCCCCTGGAAGCCGGGGCACAGACGCGAGCACAGCATATCATGGACAAT
GGAAGGAGTCACAACCATCAGCTGGTGTAATCCCTCATGTGCCCCAGTCAGGGCAGAGCCAAGGCAGTAC
TCCTGTATCTGTGGATCATGTCCAACTACCTGTCGACTTTGCGCAGGCGATGATGTCTATGATGGAGGCG
TTATCACAGAAGGTGAGTAA
Protein Sequence 
>gi|219964717|gb|ACL68410.1| V protein [Newcastle disease virus]
MATFTDAEIDDIFETSGTVIDSIITAQGKSVETVGRSAIPQGKTKALSTAWEKHGNIQSSAGQDASDQQD
RPDKQPSTPEQATPHNDPPATSNEPLPTQAAGEAGDTQLKTGASNSLLSMLDKLSNKSSNAKKGATVEPP
RGPSSTSGPTTWESAGPWKQPGKTATPGQGRPWKPGHRREHSISWTMEGVTTISWCNPSCAPVRAEPRQY
SCICGSCPTTCRLCAGDDVYDGGVITEGE
Molecule Role Virulence factor
Molecule Role Annotation Compared to the wild-type virus, mutants lacking either six nucleotides of the conserved editing site or the unique C-terminal part of the V protein produced as much as 5, 000-fold fewer infectious progeny in vitro or 200,000-fold fewer in 6-day-old embryonated chicken eggs. a mutant (NDV-P1) with one nucleotide substitution (UUCUUCCC) showed markedly attenuated pathogenicity for SPF chicken embryos. (Mebatsion et al., 2001)
References
Mebatsion et al., 2001: Mebatsion T, Verstegen S, De Vaan LT, Römer-Oberdörfer A, Schrier CC. A recombinant newcastle disease virus with low-level V protein expression is immunogenic and lacks pathogenicity for chicken embryos. Journal of virology. 2001; 75(1); 420-428. [PubMed: 11119610].