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K196R

Victor ID 5075
Gene Name K196R
Sequence Strain (Species/Organism) African swine fever virus
NCBI Gene ID 1488815
NCBI Protein GI 9628158
Locus Tag ASFVgp045
Genbank Accession AF504896
Protein Accession NP_042744
Taxonomy ID 10497
Gene Starting Position 47029
Gene Ending Position 47619
Gene Strand (Orientation) ?
Protein Name thymidine kinase
Protein pI 9.66
Protein Weight 21328.47
Protein Length 196
DNA Sequence 
>gi|9628113:47029-47619 African swine fever virus, complete genome
AATGAATATAATTAGGAAGCTTAAGCCTGGAACAATTAGCCTTGTGCTGGGACCCATGTTTGCCGGCAAA
ACTACGTTTCTTATTCATTGCATTTACATGCTCGAACGTTTGGAAAAAAAAGTAGTCTTCATAAAATCTA
CCAAAAACACCCGAGACAAAACTATTAAAACACACTCCGGTATACAGCTACGACCCAAGCAATGTAAAAT
CATAGAAAGCACACAGTTATCTGACGTGGGATCTCTCACCGATATCCATGCAGTTGTCGTAGATGAAGCG
CATTTTTTTGACGATTTAATAAAATGCCGCACCTGGGCAGAGGAAGAAAAAATTATTATTCTTGCGGGAC
TCAATGCTTCCTTCGAGCAGAAAATGTTTCCGCCCATCGTTCGTATTTTTCCTTACTGCAGCTGGGTTAA
GTATATTGGCCGCACCTGTATGAAATGTAACCAACATAATGCATGCTTTAATGTGCGTAAGAACGCAGAC
AAGACGCTTATCCTTGCGGGAGGAAGTGAACTGTACGTAACATGTTGTAACAACTGTCTAAAAAATACAT
TTATTAAGCAGTTGCAACCTATTAAATATTA
Protein Sequence 
>gi|9628158|ref|NP_042744.1| thymidine kinase [African swine fever virus]
MNIIRKLKPGTISLVLGPMFAGKTTFLIHCIYMLERLEKKVVFIKSTKNTRDKTIKTHSGIQLRPKQCKI
IESTQLSDVGSLTDIHAVVVDEAHFFDDLIKCRTWAEEEKIIILAGLNASFEQKMFPPIVRIFPYCSWVK
YIGRTCMKCNQHNACFNVRKNADKTLILAGGSELYVTCCNNCLKNTFIKQLQPIKY
Molecule Role Virulence factor
Molecule Role Annotation The Malawi TK deletion mutant showed reduced virulence for swine, producing transient fevers, lower viremia titers, and reduced mortality. In contrast, 100% mortality was observed for swine inoculated with the TK+ revertant virus. (Moore et al., 1998)
References
Moore et al., 1998: Moore DM, Zsak L, Neilan JG, Lu Z, Rock DL. The African swine fever virus thymidine kinase gene is required for efficient replication in swine macrophages and for virulence in swine. Journal of virology. 1998; 72(12); 10310-10315. [PubMed: 9811782].