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gC

Victor ID 5073
Gene Name gC
NCBI Nucleotide GI 378556085
NCBI Protein GI 378556086
Protein Accession AFC17871.1
Other Database IDs CDD:223031
CDD:254230
CDD:223030
Taxonomy ID 10326
Gene Strand (Orientation) ?
Protein Name glycoprotein C
Protein Length 468
Protein Note envelope glycoprotein C; Provisional
DNA Sequence 
>gi|378556085|gb|JQ692313.1| Equid herpesvirus 1 glycoprotein C gene, complete cds
CACCCAGCCCCCGCGAGATGTGGTTGCCTAATCTCGTGAGATTTGTGGCGGTCGCGTATCTAATCTGTGC
CGGGGCAATGTTACCTTATGCCGCTGGGGCTAGTGCTAGCCCCAGCCAGAGTACGTCCGCAACACCCACT
CACACAACTCCGAATCTAACGACCGCACACGGTACGAGCTCTGACAACACAACTAACGCAAACGGTACCG
ACTCTACACACTCCCATGAAACCACAATCACCTGCACCAAGAGTCTAATATCTGTGCCCTACTACAAATC
TGTCGATATGAACTGTACAACGTCGGTAGGCGTAAATTATAGTGAGTACCGCCTCCAGATTTACTTGAAC
CAGCGCACCCCATTTTCGGGTACGCCACCCGGAGACGAGGAAAACTACATCAACCATAACGCCACCAAGG
ATCAGACTCTGCTGTTATTCTCAACGGCAGAGAGGAAAAAATCTCTAAGGGGTGGCCAGCTGGGAGTTAT
CCCAGACAGGCTACCAAAGCGCCAGCTGTTTAACCTTCCCCTCCACACGGAAGGTGGTACAAAGTTTCCA
CTGACCATCAAATCTGTAGATTGGCGGACGGCCGGCATTTACGTGTGGTCCTTGTATGCCAAAAATGGCA
CGCTCGTTAACAGTACCAGCGTTACCGTCTCAACCTACAACGCACCGTTGCTGGACCTTTCCGTTCACCC
GAGCCTGAAGGGTGAAAACTACAGGGCCACGTGCGTCGTCGCAAGCTACTTTCCACACAGCTCCGTCAAG
CTGCGGTGGTACAAAAATGCCCGCGAGGTGGACTTTACAAAGTACGTTACGAACGCCTCAAGCGTGTGGG
TAGACGGGCTAATCACGCGAATCTCTACGGTGTCTATCCCGGTCGACCCGGAGGAGGAATACACCCCCAG
TCTTCGCTGTAGCATAGACTGGTACAGGGACGAAGTATCATTTGCTCGCATAGCCAAAGCTGGCACACCC
TCTGTGTTTGTGGCCCCAACCGTGTCCGTTGCGGTAGAAGACGGAGACGCCGTCTGTACGGCTAAATGTG
TACCGAGCACCGGGGTGTTCGTATCGTGGTCCGTGAACGACCATCTACCAGGGGTTCCGTCGCAAGACAT
GACAACCGGAGTCTGCTCTAGCCACTCGGGATTGGTTAACATGCAAAGCCGTCGGCCCCTCTCAGAAGAG
AATGGGGAGAGGGAGTATAGCTGCATAATAGAGGGGTACCCCGACGGCCTGCCTATGTTTTCGGACACAG
TAGTGTATGACGCCTCCCCGATTGTTGAGGACAGGCCGGTTTTGACGAGCATCATCGCAGTTACTTGCGG
GGCCGCGGCACTGGCGCTGGTTGTCCTCATCACAGCCGTCTGTTTTTACTGCTCCAAACCCTCGCAGGCG
CCGTACAAGAAGTCTGACTTTTAGGCTGGACCGCTCGCCCCCAAACAACCTATTTGTCAAAACTACAGTT
TGGGGCGCTGGTAAAAACAGTCGGTGGGCTCACACAAGTCGTCCGCATAGGCCAA
Protein Sequence 
>gi|378556086|gb|AFC17871.1| glycoprotein C [Equid herpesvirus 1]
MWLPNLVRFVAVAYLICAGAMLPYAAGASASPSQSTSATPTHTTPNLTTAHGTSSDNTTNANGTDSTHSH
ETTITCTKSLISVPYYKSVDMNCTTSVGVNYSEYRLQIYLNQRTPFSGTPPGDEENYINHNATKDQTLLL
FSTAERKKSLRGGQLGVIPDRLPKRQLFNLPLHTEGGTKFPLTIKSVDWRTAGIYVWSLYAKNGTLVNST
SVTVSTYNAPLLDLSVHPSLKGENYRATCVVASYFPHSSVKLRWYKNAREVDFTKYVTNASSVWVDGLIT
RISTVSIPVDPEEEYTPSLRCSIDWYRDEVSFARIAKAGTPSVFVAPTVSVAVEDGDAVCTAKCVPSTGV
FVSWSVNDHLPGVPSQDMTTGVCSSHSGLVNMQSRRPLSEENGEREYSCIIEGYPDGLPMFSDTVVYDAS
PIVEDRPVLTSIIAVTCGAAALALVVLITAVCFYCSKPSQAPYKKSDF
Molecule Role Virulence factor
Molecule Role Annotation Infection of mice with L11(delta)gC did not cause EHV-1-related disease, whereas mice infected with either RacL11 or R-L11(delta)gC exhibited massive bodyweight losses, high virus titers in the lungs, and viremia. (Osterrieder, 1999)
References
Osterrieder, 1999: Osterrieder N. Construction and characterization of an equine herpesvirus 1 glycoprotein C negative mutant. Virus research. 1999; 59(2); 165-177. [PubMed: 10082388].