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ORF71

Victor ID 5072
Gene Name ORF71
NCBI Nucleotide GI 17221115
NCBI Protein GI 17221116
Protein Accession AAK61485.1
Other Database IDs CDD:203358
Taxonomy ID 10326
Gene Strand (Orientation) ?
Protein Name glycoprotein gp2
Protein Length 826
Protein Note Equine herpesvirus glycoprotein gp2; pfam05955
DNA Sequence 
>gi|17221115|gb|AY034645.1| Equine herpesvirus 1 strain 438/77 glycoprotein gp2 (ORF71) gene, complete cds
GACTTGAGTACGTTGCTTAACACCTGTCTTTTAAAAGTTTCAAATCAAAAACATTGTTGTCTGTAATAAC
TGAGTGTGGTTTTAAAAATACTAAATCGCGGCAATTCCGGAAATAGCCCCATACAAAAGGGAGGGTTGTT
GGTGTTTAGAAAATAGTTTCCCCGTTGATGAGTTTCGCGTAGAGGTCTAACTCATCCGCGATGGGGTTCA
TCTATGCGCGCAAACTGTTGCTGTGCATGGCTGTTAGTATATACGCCATAGGGTCCACTACAACAACTGA
GACTACCACCTCTAGCTCGTCCACGTCTGGGAGTGGCCAGTCTACATCCAGTGGGACCACTAATAGTAGC
AGTTCTCCCACCACGAGTCCACCTACCACATCTTCATCTCCCCCCACATCAACCCACACATCCTCCCCAT
CTTCAACCTCTACCCAATCGTCGTCAACGGCGGCGACAAGCTCGTCTGCACCCTCTACAGCGTCCAGCAC
AACCTCTATTCCAACATCCACATCAACAGAAACCACCACAACAACCCCAACCGCATCTACAACGACCCCA
ACAACAACGACCGCGGCTCCCACAACGGCCGCTACAACCACAGCTGTTACTACAGCCGCGTCTACATCAG
CGGAAACCACCACAGCTACTGCGACTGCTACCTCAACCCCAACCACAACTACGCCTACGTCCACAACAAC
TACTACAGCTACCACCACTGTTCCAACAACCGCTTCTACAACAACTGATACGACCACAGCAGCAACGACC
ACAGCAGCAACGACCACAGCAGCAACGACCACAGCAGCAACGACCACAGCAGCAACGACCACAGCAGCAA
CGACCACAGCAGCAACGACCACCGCGGCTACTACTTCCTCTGCAACCACCGCGGCTACTACTTCCTCTGC
AACCACCGCGGCTACCACCACCGCGGCTACCACCACCGCGGCTACCACCACCGCGGCTACCACCACCGCG
GCTACCACCACCGCGGCTACCACCACCGCGGCTACCACCACCGCGGCTACCACCACCGCGGCTACCACCA
CCGCGGCTACCACAACGGGGTCTCCAACCTCTGGTTCAACATCTACTACAGGGGCTTCCACGTCCACCCC
CTCAGCTTCCACTGCCACATCTGCCACTCCCACATCGACGTCAACATCAGCTGCGGCTACTACATCTACC
CCTACCCCAACTTCAGCTGCAACATCAGCAGAGTCTACCACAGAGGCTCCAACATCCACACCCACTACTG
ATACGACCACCCCTTCGGAGGCAACCACAGCTACTACATCACCGGAGTCTACCACAGTTTCAGCCTCGAC
TACCTCTGCTACGACCACGGCATTCACAACCGAGTCCCACACATCGCCGGATTCGTCTACTGGGTCTACA
TCCACAGCCGAACCCAGCTCAACGTTTACTTTAACACCTTCTACTGCGACCCCCTCCACGGATCAGTTCA
CAGGGTCATCTGCCTCAACAGAGTCTGACTCGACCGACTCTTCCACCGTGCCCACGACTGGGACTGAATC
TATAACAGAAAGCTCATCGACCACCGAGGCGTCAACTAACTTGGGATCGTCAACCTACGAGAGTACCGAA
GCCTTGGAAACTCCAGACGGGAATACAACTTCCGGAAATACCACCCCATCACCTTCCCCGCGTACCCCAA
GCTTTGCTGATACCCAACAGACCCCAGACAATGGTGTATCAACCCAACATACCACCATCAATGACCACAC
CACCGCCAACGCTCAAAAACACGCAGGGCACCACAGAGGTCGCGCAGGGGGTCGTCGGGGTAGCCCTCAG
GGGGGGTCACACACAACACCACACCCAGACCGTTTGACTCCTTCTCCAGACGACACCTATGACGATGATA
CAAATCACCCTAACGGTAGGAACAATTCAATAGAGATCGTGCCTCAGCTCCCGCCAGACCGACCCATCAT
AGAGCTGGGGGTGGCGACTCTCAGAAAAAACTTTATGGAGGCGTCCTGTACTGTGGAGACTAACTCAGGC
TTGGCGATTTTTTGGAAAATCGGCAACGCAAGCGTAGACGCGTTTAATCGGGGAACTACTCACACTCGGC
TGATGCGCAATGGGGTACCGGTTTACGCCCTCGTATCTACGCTTAGAGTTCCGTGGTTAAATGTTATTCC
ACTAACAAAAATTACTTGCGCTGCTTGCCCCACGAATCTAGTCGCCGGCGATGGGGTGGACCTCAACTCA
TGTACCACCAAATCAACCACAATACCGTGTCCGGGCCAACAGCGCACCCATATTTTTTTCTCTGCGAAAG
GGGACAGGGCTGTGTGTATCACATCAGAACTGGTGTCCCAGCCCACAATAACTTGGTCAGTTGGATCAGA
TAGGTTGCGTAACGATGGATTTTCTCAGACGTGGTATGGAATACAGCCCGGGGTGTGTGGTATACTGCGC
AGCGAGGTTCGCATTCACCGCACCACCTGGCGCTTTGGATCAACATCAAAGGACTATCTCTGTGAGGTCA
GCGCATCGGACTCAAAGACGAGCGATTACAAAGTGCTACCCAACGCCCACTCAACTTCCAACTTCGCTTT
AGTGGCTGCGACCACGCTAACAGTGACAATTTTATGCCTGCTGTGCTGCTTGTACTGTATGTTAACCCGC
CCCCGAGCGTCTGTATATTAACTCAAAAATTATCCCTTGGCCTTTACAACCAGTGGTGGCGTGTATGCAG
AAGCGTGCCACCGCCCTGGTACGTGTTGAGCTC
Protein Sequence 
>gi|17221116|gb|AAK61485.1| glycoprotein gp2 [Equid herpesvirus 1]
MGFIYARKLLLCMAVSIYAIGSTTTTETTTSSSSTSGSGQSTSSGTTNSSSSPTTSPPTTSSSPPTSTHT
SSPSSTSTQSSSTAATSSSAPSTASSTTSIPTSTSTETTTTTPTASTTTPTTTTAAPTTAATTTAVTTAA
STSAETTTATATATSTPTTTTPTSTTTTTATTTVPTTASTTTDTTTAATTTAATTTAATTTAATTTAATT
TAATTTAATTTAATTSSATTAATTSSATTAATTTAATTTAATTTAATTTAATTTAATTTAATTTAATTTA
ATTTAATTTGSPTSGSTSTTGASTSTPSASTATSATPTSTSTSAAATTSTPTPTSAATSAESTTEAPTST
PTTDTTTPSEATTATTSPESTTVSASTTSATTTAFTTESHTSPDSSTGSTSTAEPSSTFTLTPSTATPST
DQFTGSSASTESDSTDSSTVPTTGTESITESSSTTEASTNLGSSTYESTEALETPDGNTTSGNTTPSPSP
RTPSFADTQQTPDNGVSTQHTTINDHTTANAQKHAGHHRGRAGGRRGSPQGGSHTTPHPDRLTPSPDDTY
DDDTNHPNGRNNSIEIVPQLPPDRPIIELGVATLRKNFMEASCTVETNSGLAIFWKIGNASVDAFNRGTT
HTRLMRNGVPVYALVSTLRVPWLNVIPLTKITCAACPTNLVAGDGVDLNSCTTKSTTIPCPGQQRTHIFF
SAKGDRAVCITSELVSQPTITWSVGSDRLRNDGFSQTWYGIQPGVCGILRSEVRIHRTTWRFGSTSKDYL
CEVSASDSKTSDYKVLPNAHSTSNFALVAATTLTVTILCLLCCLYCMLTRPRASVY
Molecule Role Virulence factor
Molecule Role Annotation Irrespective of the reduced pathogenicity of the gene 71 mutant, infected mice were protected against a challenge with wild-type EHV-1. These findings highlight the potential of ED71 as a vaccine candidate. (Marshall et al., 1997)
References
Marshall et al., 1997: Marshall KR, Sun Y, Brown SM, Field HJ. An equine herpesvirus-1 gene 71 deletant is attenuated and elicits a protective immune response in mice. Virology. 1997; 231(1); 20-27. [PubMed: 9143298].