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9GL

Victor ID 5067
Gene Name 9GL
NCBI Nucleotide GI 6759648
NCBI Protein GI 6759649
Protein Accession AAF27977.1
Taxonomy ID 10497
Gene Strand (Orientation) ?
Protein Name Za-9GL protein
Protein Note pathogenic pig isolate Zaire 67, Katanga, Zaire
DNA Sequence 
>gi|6759648|gb|AF081181.1| African swine fever virus Za-9GL protein (9GL) gene, complete cds
GTGATGATGTAATGAATAGGAACATCATTCTTGTGCTCAGCGGGCACGTTATAGAGATGACCAGGCTCCA
ATAAAGTCGGTTTTCCCATATTCTATTGTTTTAAGGATTGATTGTTCATAAATATTTTTATACTCTGACC
AAGAAATTATTTTTTTATTAAGCCGGTTATTTACGTTGTTATGGAACGCGAAGGTCCAGTACTGAAAGTC
CTCCGAGTTGTTTAATGTCAAGGGATTTTTTGTAAGATACGAAAAGGCGTGGTGCTGACACCTGGTGCAT
GGCAGAGACTCGATAAAGTTCAGTATCCATTGGATGGCTTCATATTTTTCTTTCCAGCTAGGAGCGTCTG
AAAAAAAGATAGCATATAGATGCAAGGATCGCCAGTATTTAGGTCCCCAATGCAACATTTATAACCTTTT
GAAAAATCTCATTCCATATAGAGG
Molecule Role Virulence factor
Molecule Role Annotation The Delta9GL virus was markedly attenuated in swine. In contrast to 9GL-R infection, where mortality was 100%, all Delta9GL-infected animals survived infection. With the exception of a transient fever response in some animals, Delta9GL-infected animals remained clinically normal and exhibited significant 100- to 10,000-fold reductions in viremia titers. All pigs previously infected with Delta9GL survived infection when subsequently challenged with a lethal dose of virulent parental MAL. Thus, ASFV 9GL gene deletion mutants may prove useful as live-attenuated ASF vaccines. (Lewis et al., 2000)
References
Lewis et al., 2000: Lewis T, Zsak L, Burrage TG, Lu Z, Kutish GF, Neilan JG, Rock DL. An African swine fever virus ERV1-ALR homologue, 9GL, affects virion maturation and viral growth in macrophages and viral virulence in swine. Journal of virology. 2000; 74(3); 1275-1285. [PubMed: 10627538].