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D10R

Victor ID 5053
Gene Name D10R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707571
NCBI Protein GI 66275912
Locus Tag VACWR115
Genbank Accession M15058
Protein Accession YP_232997
Taxonomy ID 10245
Gene Starting Position 104654
Gene Ending Position 105400
Gene Strand (Orientation) +
Protein Name contains mutT-like motif of NTP-phosphohydrolase for DNA repair
Protein pI 8.03
Protein Weight 28018.79
Protein Length 248
Protein Note similar to VACCP-D10R
DNA Sequence 
>gi|66275797:104654-105400 Vaccinia virus, complete genome
AATGAACTTTTACAGATCTAGTATAATTAGTCAGATTATTAAGTATAATAGACGACTAGCTAAGTCTATT
ATTTGCGAGGATGACTCTCAAATTATTACACTCACGGCATTCGTTAACCAATGCCTATGGTGTCATAAAC
GAGTATCCGTGTCCGCTATTTTATTAACTACTGATAACAAAATATTAGTATGTAACAGACGAGATAGTTT
TCTCTATTCTGAAATAATTAGAACTAGAAACATGTTTAGAAAGAAACGATTATTTCTGAATTATTCCAAT
TATTTGAACAAACAGGAAAGAAGTATACTATCGTCATTTTTTTCTCTAGATCCAGCTACTGCTGATAATG
ATAGAATAGACGCTATTTATCCGGGTGGCATACCCAAAAGGGGTGAGAATGTTCCAGAGTGTTTATCCAG
GGAAATTAAAGAAGAAGTTAATATAGACAATTCTTTTGTATTCATAGACACTCGGTTTTTTATTCATGGC
ATCATAGAAGATACCATTATTAATAAATTTTTTGAGGTAATCTTCTTTGTCGGAAGAATATCTCTAACGA
GTGATCAAATCATTGATACATTTAAAAGTAATCATGAAATCAAGGATCTAATATTTTTAGATCCGAATTC
AGGTAATGGACTCCAATACGAAATTGCAAAATATGCTCTAGATACTGCAAAACTCAAATGTTATGGCCAT
AGAGGATGTTATTACGAATCATTAAAAAAATTAACTGAGGATGATTG
Protein Sequence 
>gi|66275912|ref|YP_232997.1| contains mutT-like motif of NTP-phosphohydrolase for DNA repair [Vaccinia virus]
MNFYRSSIISQIIKYNRRLAKSIICEDDSQIITLTAFVNQCLWCHKRVSVSAILLTTDNKILVCNRRDSF
LYSEIIRTRNMFRKKRLFLNYSNYLNKQERSILSSFFSLDPATADNDRIDAIYPGGIPKRGENVPECLSR
EIKEEVNIDNSFVFIDTRFFIHGIIEDTIINKFFEVIFFVGRISLTSDQIIDTFKSNHEIKDLIFLDPNS
GNGLQYEIAKYALDTAKLKCYGHRGCYYESLKKLTEDD
Molecule Role Virulence factor
Molecule Role Annotation Despite the mild effects in vitro, both mutants were more attenuated than the revertants in intranasal and intraperitoneal mouse models, and less infectious virus was recovered from organs. In addition, there was less lung histopathology following intranasal infection with mutant viruses. (Liu et al., 2014)
References
Liu et al., 2014: Liu SW, Wyatt LS, Orandle MS, Minai M, Moss B. The D10 decapping enzyme of vaccinia virus contributes to decay of cellular and viral mRNAs and to virulence in mice. Journal of virology. 2014; 88(1); 202-211. [PubMed: 24155373].