Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; cd00048
The results suggested that deletion of the TE3L gene decreased the virulence and neurovirulence significantly in mice and rabbit models, yet retained the immunogenicity. Thus, the deletion of TE3L improved the safety of the VTT vector; this approach may yield a valuable resource for studies of recombinant VACV-vectored vaccines. (Wang et al., 2012)
References
Wang et al., 2012: Wang Y, Kan S, Du S, Qi Y, Wang J, Liu L, Ji H, He D, Wu N, Li C, Chi B, Li X, Jin N. Characterization of an attenuated TE3L-deficient vaccinia virus Tian Tan strain. Antiviral research. 2012; 96(3); 324-332. [PubMed: 23084929].
