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O1L

Victor ID 5050
Gene Name O1L
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707601
NCBI Protein GI 66275865
Locus Tag VACWR068
Genbank Accession AY243312
Protein Accession YP_232950
Taxonomy ID 10245
Gene Starting Position 57345
Gene Ending Position 59345
Gene Strand (Orientation) -
Protein Name Hypothetical protein
Protein pI 7.03
Protein Weight 72301.11
Protein Length 666
Protein Note hypothetical protein; similar to vaccinia virus strain Copenhagen O1L; The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins
DNA Sequence 
>gi|66275797:57345-59345 Vaccinia virus, complete genome
ATTAACGAGTTCCATTTATATCATCCAATATTATTGAAATGACGTTGATGGACAAATGATACAAATAAGA
AGGTACGGTACCTTTGTCCACCATCTCCTCCAATTCATGCTCTATTTTGTCATTAACTTTAATGTATGAA
AACAGTACGCCACATGCTTCCATGACAGTGTGTAACACTTTGGATACAAAATGTTTGACATTAGTATAAT
TGTTCAAGACTGTCAATCTATAATAGATAGTAGCTATAATATATTCTATGATGGTATTGAAGAAGATGAC
AACCTTGGCATATTGATCATTTAACACAGACATGGTATCAACAGATAGCTTGAATGAAAGAGAATCAGTA
ATTGGAATAAGCGTCTTCTCGATGGAGTGTCCGTATACCAACATGTCTGATATTTTGATGTATTCCATTA
AATTATTTAGTTTTTTCTTTTTATTCTCGTTAAACAGCATTTCTGTCAACGGACCCCAACATCGTTGACC
GATTAAGTTTTGATTGATTTTTCCGTGTAAGGCGTATCTAGTCAGATCGTATAGCCTATCCAATAATCCA
TCGTCTGTGTGTAGATCACATCGTACACTTTTTAATTCTCTATAGAAGAGCGACAGACATCTGGAGCAAT
TACAGACAGCAATTTCTTTATTCTCTACAGATGTAAGATACTTGAAGACATTCCTATGATGATGCAGAAT
TTTGGATAACACGGTATTGATGGTATCTGTTACCATAATTCCTTTGATGGCTGATAGTGTCAGAGCACAA
GATTTCCAATCTTTGACAATTTTTAGCACCATTATCTTTGTTTTGATATCTATATCAGACAGCATGGTGC
GTCTGACAACACAAGGATTAAGACGGAAAGATGAAATGATTCTCTCAACATCTTCAATGGATACCTTGCT
ATTTTTTCTGGCATTATCTATATGTGCGAGAATATCCTCTAGAGAATCAGTATCCTTTTTGATGATAGTG
GATCTCAATGACATGGGACGTCTAAACCTTCTTATTCTATCACCAGATTGCATGGTGATTTGTCTTCTTT
CTTTTATCATAATGTAATCTCTAAATTCATCGGCAAATTGTCTATATCTAAAATCATAATATGAGATGTT
TACCTCTACAAATATCTGTTCGTCCAATGTTAGAGTATTTACATCAGTTTTGTATTCCAAATTAAACATG
GCAACGGATTTAATTTTATATTCCTCTATTAAGTCCTCGTCGATAATAACAGAATGTAGATAATCATTTA
ATCCATCGTACATGGTTGGAAGATGCTCGTTGACAAAATCTTTAATTGTCTTGATGAAGGTGGGACTATA
TCTAACATCTTGATTAATAAAATTTATAACATTGTCCATAGGATACTTTGTAACTAGTTTTATACACATC
TCTTCATCGGTAAGTTTAGACAGAATATCGTGAACAGGTGGTATATTATATTCATCAGATATACGAAGAA
CAATGTCCAAATCTATATTGTTTAATATATTATATAGATGTAGTGTAGCTCCTACAGGAATATCTTTAAC
TAAGTCAATGATTTCATCAACCGTTAGATCTATTTTAAAGTTAATCATATAGGCATTGATTTTTAAAAGG
TATGTAGCCTTGACTACATTCTCATTAATTAACCATTCCAAGTCACTGTGTGTAAGAAGATTATATTCTA
TCATAAGCTTGACTACATTTGGTCCCGATACCATTAAAGAATTCTTATGATATAAGGAAACAGATTTTAG
GTACTCATCTACTCTACAAGAATTTTGGAGAGCCTTAACGATATCAGTGACGTTTATTATTTCAGGAGGA
AAAAACCTAACATTGAGAATATCGGAATTAATAGCTTCCAGATACAGTGATTTTGGCAATAGTCCGTGTA
ATCCATAATCCAGTAACACGAGCTGGTGCTTGCTAGACACCTTTTCAATGTTTAATTTTTTTGAAATAAG
CTTTGATAAAGCCTTCCTCGCAAATTCCGGATACATGAACA
Protein Sequence 
>gi|66275865|ref|YP_232950.1| hypothetical protein VACWR068 [Vaccinia virus]
MFMYPEFARKALSKLISKKLNIEKVSSKHQLVLLDYGLHGLLPKSLYLEAINSDILNVRFFPPEIINVTD
IVKALQNSCRVDEYLKSVSLYHKNSLMVSGPNVVKLMIEYNLLTHSDLEWLINENVVKATYLLKINAYMI
NFKIDLTVDEIIDLVKDIPVGATLHLYNILNNIDLDIVLRISDEYNIPPVHDILSKLTDEEMCIKLVTKY
PMDNVINFINQDVRYSPTFIKTIKDFVNEHLPTMYDGLNDYLHSVIIDEDLIEEYKIKSVAMFNLEYKTD
VNTLTLDEQIFVEVNISYYDFRYRQFADEFRDYIMIKERRQITMQSGDRIRRFRRPMSLRSTIIKKDTDS
LEDILAHIDNARKNSKVSIEDVERIISSFRLNPCVVRRTMLSDIDIKTKIMVLKIVKDWKSCALTLSAIK
GIMVTDTINTVLSKILHHHRNVFKYLTSVENKEIAVCNCSRCLSLFYRELKSVRCDLHTDDGLLDRLYDL
TRYALHGKINQNLIGQRCWGPLTEMLFNENKKKKLNNLMEYIKISDMLVYGHSIEKTLIPITDSLSFKLS
VDTMSVLNDQYAKVVIFFNTIIEYIIATIYYRLTVLNNYTNVKHFVSKVLHTVMEACGVLFSYIKVNDKI
EHELEEMVDKGTVPSYLYHLSINVISIILDDINGTR
Molecule Role Virulence factor
Molecule Role Annotation CVA-ÃâO1L showed reduced plaque size and an attenuated cytopathic effect (CPE) in infected cell cultures and reduced virulence and spread from lungs to ovaries in intranasally infected BALB/c mice. (Schweneker et al., 2012)
References
Schweneker et al., 2012: Schweneker M, Lukassen S, Späth M, Wolferstätter M, Babel E, Brinkmann K, Wielert U, Chaplin P, Suter M, Hausmann J. The vaccinia virus O1 protein is required for sustained activation of extracellular signal-regulated kinase 1/2 and promotes viral virulence. Journal of virology. 2012; 86(4); 2323-2336. [PubMed: 22171261].