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A56R

Victor ID 5049
Gene Name A56R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707652
NCBI Protein GI 66275978
Locus Tag VACWR181
Genbank Accession M93956
Protein Accession YP_233063
Taxonomy ID 10245
Gene Starting Position 162182
Gene Ending Position 163126
Gene Strand (Orientation) +
Protein Name hemagglutinin
Protein pI 4.07
Protein Weight 32593.98
Protein Length 314
Protein Note similar to VACCP-A56R; EEV; type-I membrane glycoprotein; inhibits cell fusion
DNA Sequence 
>gi|66275797:162182-163126 Vaccinia virus, complete genome
TATGACACGATTACCAATACTTTTGTTACTAATATCATTAGTATACGCTACACCTTTTCCTCAGACATCT
AAAAAAATAGGTGATGATGCAACTCTATCATGTAATCGAAATAATACAAATGACTACGTTGTTATGAGTG
CTTGGTATAAGGAGCCCAATTCCATTATTCTTTTAGCTGCTAAAAGCGACGTCTTGTATTTTGATAATTA
TACCAAGGATAAAATATCTTACGACTCTCCATACGATGATCTAGTTACAACTATCACAATTAAATCATTG
ACTGCTAGAGATGCCGGTACTTATGTATGTGCATTCTTTATGACATCAACTACAAATGACACTGATAAAG
TAGATTATGAAGAATACTCCACAGAGTTGATTGTAAATACAGATAGTGAATCGACTATAGACATAATACT
ATCTGGATCTACACATTCACCGGAAACTAGTTCTAAGAAACCTGATTATATAGATAATTCTAATTGCTCG
TCGGTATTCGAAATCGCGACTCCGGAACCAATTACTGATAATGTAGAAGATCATACAGACACCGTCACAT
ACACTAGTGATAGCATTAATACAGTAAGTGCATCATCTGGAGAATCCACAACAGACGAGACTCCGGAACC
AATTACTGATAAAGAAGATCATACAGTTACAGACACTGTCTCATACACTACAGTAAGTACATCATCTGGA
ATTGTCACTACTAAATCAACCACCGATGATGCGGATCTTTATGATACGTACAATGATAATGATACAGTAC
CACCAACTACTGTAGGCGGTAGTACAACCTCTATTAGCAATTATAAAACCAAGGACTTTGTAGAAATATT
TGGTATTACCGCATTAATTATATTGTCGGCCGTGGCAATTTTCTGTATTACATATTATATATATAATAAA
CGTTCACGTAAATACAAAACAGAGAACAAAGTCTA
Protein Sequence 
>gi|66275978|ref|YP_233063.1| hemagglutinin [Vaccinia virus]
MTRLPILLLLISLVYATPFPQTSKKIGDDATLSCNRNNTNDYVVMSAWYKEPNSIILLAAKSDVLYFDNY
TKDKISYDSPYDDLVTTITIKSLTARDAGTYVCAFFMTSTTNDTDKVDYEEYSTELIVNTDSESTIDIIL
SGSTHSPETSSKKPDYIDNSNCSSVFEIATPEPITDNVEDHTDTVTYTSDSINTVSASSGESTTDETPEP
ITDKEDHTVTDTVSYTTVSTSSGIVTTKSTTDDADLYDTYNDNDTVPPTTVGGSTTSISNYKTKDFVEIF
GITALIILSAVAIFCITYYIYNKRSRKYKTENKV
Molecule Role Virulence factor
Molecule Role Annotation We have shown that insertion of the three vaccinia virus (VACV) promoter-driven foreign gene expression cassettes encoding Renilla luciferase-Aequorea GFP fusion protein, β-galactosidase, and β-glucuronidase into the F14.5L, J2R, and A56R loci of the VACV LIVP genome, respectively, results in a highly attenuated mutant strain GLV-1h68. This strain shows tumor-specific replication and is capable of eradicating tumors with little or no virulence in mice. (Chen et al., 2011)
References
Chen et al., 2011: Chen NG, Yu YA, Zhang Q, Szalay AA. Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice. Journal of translational medicine. 2011; 9; 164. [PubMed: 21951588].