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A43R

Victor ID 5046
Gene Name A43R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707698
NCBI Protein GI 66275965
Locus Tag VACWR168
Genbank Accession M72474
Protein Accession YP_233050
Taxonomy ID 10245
Gene Starting Position 150766
Gene Ending Position 151350
Gene Strand (Orientation) +
Protein Name putative type-I membrane glycoprotein
Protein pI 8.84
Protein Weight 21485.28
Protein Length 194
Protein Note similar to VACCP-A43R
DNA Sequence 
>gi|66275797:150766-151350 Vaccinia virus, complete genome
AATGATGATGATGAAATGGATAATATCCATATTGACGATGTCAATAATGCCGGTATTGGCATACAGCTCA
TCGATTTTTAGATTTCATTCAGAGGATGTGGAATTATGTTATGGGCATTTGTATTTTGATAGGATCTATA
ATGTAGTAAATATAAAATATAATCCGCATATTCCATATAGATATAATTTTATTAATCGCACGTTAACCGT
AGATGAACTAGACGATAATGTCTTTTTTACACATGGTTATTTTTTAAAACACAAATATGGTTCACTTAAT
CCTAGTTTGATTGTCTCATTATCAGGAAACTTAAAATATAATGATATACAATGCTCAGTAAATGTATCGT
GTCTCATTAAAAATTTGGCAACGAGTACATCTACTATATTAACATCTAAACATAAGACTTATTCTCTACA
TCGGTCCACGTGTATTACTATAATAGGATACGATTCTATTATATGGTATAAAGATATAAATGACAAGTAT
AATGGCATCTATGATTTTACTGCAATATGTATGCTAATAGCGTCTACATTGATAGTGACCATATACGTGT
TTAAAAAAATAAAAATGAACTCTTA
Protein Sequence 
>gi|66275965|ref|YP_233050.1| putative type-I membrane glycoprotein [Vaccinia virus]
MMMMKWIISILTMSIMPVLAYSSSIFRFHSEDVELCYGHLYFDRIYNVVNIKYNPHIPYRYNFINRTLTV
DELDDNVFFTHGYFLKHKYGSLNPSLIVSLSGNLKYNDIQCSVNVSCLIKNLATSTSTILTSKHKTYSLH
RSTCITIIGYDSIIWYKDINDKYNGIYDFTAICMLIASTLIVTIYVFKKIKMNS
Molecule Role Virulence factor
Molecule Role Annotation Prevention of A43R expression had no effect on plaque size or virus replication in cell culture and little effect on virulence after mouse intranasal infection. Although the A43 mutant produced significantly smaller lesions in skin of mice than the control, the amounts of virus recovered from the lesions were similar. (Sood and Moss, 2010)
References
Sood and Moss, 2010: Sood CL, Moss B. Vaccinia virus A43R gene encodes an orthopoxvirus-specific late non-virion type-1 membrane protein that is dispensable for replication but enhances intradermal lesion formation. Virology. 2010; 396(1); 160-168. [PubMed: 19900687].