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A53R

Victor ID 5045
Gene Name A53R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707710
NCBI Protein GI 66275976
Locus Tag VACWR179
Genbank Accession M58054
Protein Accession YP_233061
Taxonomy ID 10245
Gene Starting Position 159620
Gene Ending Position 159931
Gene Strand (Orientation) +
Protein Name secreted TNF-receptor-like protein
Protein pI 7.31
Protein Weight 11702.25
Protein Length 103
Protein Note similar to VACCP-A53R; CrmC, intact in some VAC strains; host defense modulator
DNA Sequence 
>gi|66275797:159620-159931 Vaccinia virus, complete genome
TATGATAATATTAAAAGATGGATATAAAGAATTTGCTGACTGCATGTACTATTTTTTACATTACTACATT
GGCTACGGCAGATATACCTACTCCGCCACCAACGGGTCATGTGACAAGGGAGAATATCTTGATAAGAGGC
ATAATCAATGTTGTAATCGGTGTCCACCTGGAGAATTTGCCAAGGTTAGATGTAATGGTAACGATAACAC
AAAATGTGAACGCTGCCCACCTCATACATATACCACAATCCCAATTATTCTAATGGATGTCATCAATGTA
GAAAATGCCCAACCGGATCATTTGATAAGGTA
Protein Sequence 
>gi|66275976|ref|YP_233061.1| secreted TNF-receptor-like protein [Vaccinia virus]
MIILKDGYKEFADCMYYFLHYYIGYGRYTYSATNGSCDKGEYLDKRHNQCCNRCPPGEFAKVRCNGNDNT
KCERCPPHTYTTIPIILMDVINVENAQPDHLIR
Molecule Role Virulence factor
Molecule Role Annotation we constructed C12L (vIL-18 binding protein) and A53R (vTNF receptor homolog) gene-deleted mutants which are based on parental TV and VTKgpe (TV expressing HIV gagpol and env gene), respectively. The pathogenicity and immunogenicity were also evaluated. Deleting these two immunomodulatory genes lessened the virulence of the parental virus in both mice and rabbit models. Notably, C12L deletion mutant attenuated the skin virulence of parental virus by as high as approximate 2 logs. (Dai et al., 2008)
References
Dai et al., 2008: Dai K, Liu Y, Liu M, Xu J, Huang W, Huang X, Liu L, Wan Y, Hao Y, Shao Y. Pathogenicity and immunogenicity of recombinant Tiantan Vaccinia Virus with deleted C12L and A53R genes. Vaccine. 2008; 26(39); 5062-5071. [PubMed: 18573290].