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Uracil DNA glycosylase (D4R/D5R) |
| Victor ID |
5044 |
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Gene Name |
Uracil DNA glycosylase (D4R/D5R) |
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NCBI Nucleotide GI |
402497
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Molecule Role |
Virulence factor |
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Molecule Role Annotation |
MUTATION: The conservation of the catalytic site in all poxvirus orthologs suggested an important role in vivo. This idea was confirmed by the decreased virulence of catalytic-site mutants when administered by the intranasal route to mice (De and Moss, 2003). |
| References |
De and Moss, 2003: De Silva FS, Moss B. Vaccinia virus uracil DNA glycosylase has an essential role in DNA synthesis that is independent of its glycosylase activity: catalytic site mutations reduce virulence but not virus replication in cultured cells. Journal of virology. 2003; 77(1); 159-166. [PubMed: 12477821].
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