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B8R

Victor ID 5042
Gene Name B8R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707661
NCBI Protein GI 66275987
Locus Tag VACWR190
Genbank Accession AF120160
Protein Accession YP_233072
Taxonomy ID 10245
Gene Starting Position 170570
Gene Ending Position 171388
Gene Strand (Orientation) +
Protein Name soluble interferon-gamma receptor-like protein
Protein pI 7.23
Protein Weight 29372.12
Protein Length 272
Protein Note similar to VACCP-B8R; host defense modulator
DNA Sequence 
>gi|66275797:170570-171388 Vaccinia virus, complete genome
CATGAGATATATTATAATTCTCGCAGTTTTGTTCATTAATAGTATACACGCTAAAATAACTAGTTATAAG
TTTGAATCCGTCAATTTTGATTCCAAAATTGAATGGACTGGGGATGGTCTATACAATATATCCCTTAAAA
ATTATGGCATCAAGACGTGGCAAACAATGTATACAAATGTACCAGAAGGAACATACGACATATCCGCATT
TCCAAAGAATGATTTCGTATCTTTCTGGGTTAAATTTGAACAAGGCGATTATAAAGTGGAAGAGTATTGT
ACGGGACTATGCGTCGAAGTAAAAATTGGACCACCGACTGTAACATTGACTGAATACGACGACCATATCA
ATTTGTACATCGAGCATCCGTATGCTACTAGAGGTAGCAAAAAGATTCCTATTTACAAACGCGGTGACAT
GTGTGATATCTACTTGTTGTATACGGCTAACTTCACATTCGGAGATTCTAAAGAACCAGTACCATATGAT
ATCGATGACTACGATTGCACGTCTACAGGTTGCAGCATAGACTTTGTCACAACAGAAAAAGTGTGCGTGA
CAGCACAGGGAGCCACAGAAGGGTTTCTCGAAAAAATTACTCCATGGAGTTCGAAAGTATGTCTGACACC
TAAAAAGAGTGTATATACATGCGCAATTAGATCCAAAGAAGATGTTCCCAATTTCAAGGACAAAATGGCC
AGAGTTATCAAGAGAAAATTTAATAAACAGTCTCAATCTTATTTAACTAAATTTCTCGGTAGCACATCAA
ATGATGTTACCACTTTTCTTAGCATGCTTAACTTGACTAAATATTCATA
Protein Sequence 
>gi|66275987|ref|YP_233072.1| soluble interferon-gamma receptor-like protein [Vaccinia virus]
MRYIIILAVLFINSIHAKITSYKFESVNFDSKIEWTGDGLYNISLKNYGIKTWQTMYTNVPEGTYDISAF
PKNDFVSFWVKFEQGDYKVEEYCTGLCVEVKIGPPTVTLTEYDDHINLYIEHPYATRGSKKIPIYKRGDM
CDIYLLYTANFTFGDSKEPVPYDIDDYDCTSTGCSIDFVTTEKVCVTAQGATEGFLEKITPWSSKVCLTP
KKSVYTCAIRSKEDVPNFKDKMARVIKRKFNKQSQSYLTKFLGSTSNDVTTFLSMLNLTKYS
Molecule Role Virulence factor
Molecule Role Annotation In rabbits, skin lesions produced by the WR B8R-deleted mutants were smaller and tended to disappear earlier than those caused by wild-type WR virus. Similar results were obtained with both independently prepared WR B8R-deleted mutants. These data strongly suggested that the product of B8R gene did play a role in virus virulence. (Sroller et al., 2001)
References
Sroller et al., 2001: Sroller V, Ludvíková V, Maresová L, Hainz P, Nĕmecková S. Effect of IFN-gamma receptor gene deletion on vaccinia virus virulence. Archives of virology. 2001; 146(2); 239-249. [PubMed: 11315635].