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B7R

Victor ID 5040
Gene Name B7R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707660
NCBI Protein GI 66275986
Locus Tag VACWR189
Genbank Accession M58056
Protein Accession YP_233071
Taxonomy ID 10245
Gene Starting Position 169967
Gene Ending Position 170515
Gene Strand (Orientation) +
Protein Name hypothetical protein
Protein pI 5.93
Protein Weight 20715.69
Protein Length 182
Protein Note uncharacterized protein; similar to vaccinia virus strain Copenhagen B7R and cowpox virus B6R; the poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins;
DNA Sequence 
>gi|66275797:169967-170515 Vaccinia virus, complete genome
AATGTATAAAAAACTAATAACGTTTTTATTTGTAATAGGTGCATTAGCATCCTATTCGAATAATGAGTAC
ACTCCGTTTAATAAACTGAGTGTAAAACTCTATATAGATGGAGTAGATAATATAGAAAATTCATATACTG
ATGATAATAATGAATTGGTGTTAAATTTTAAAGAGTACACAATTTCTATTATTACAGAGTCATGCGACGT
CGGATTTGATTCCATAGATATAGATGTTATAAACGACTATAAAATTATTGATATGTATACCATTGACTCG
TCTACTATTCAACGCAGAGGTCACACGTGTAGAATATCTACCAAATTATCATGCCATTATGATAAGTACC
CTTATATTCACAAATATGATGGTGATGAGCGACAATATTCTATTACTGCAGAGGGAAAATGCTATAAAGG
AATAAAATATGAAATAAGTATGATCAACGATGATACTCTATTGAGAAAACATACTCTTAAAATTGGATCT
ACTTATATATTTGATCGTCATGGACATAGTAATACATATTATTCAAAATATGATTTTTA
Protein Sequence 
>gi|66275986|ref|YP_233071.1| 21kDa precursor protein [Vaccinia virus]
MYKKLITFLFVIGALASYSNNEYTPFNKLSVKLYIDGVDNIENSYTDDNNELVLNFKEYTISIITESCDV
GFDSIDIDVINDYKIIDMYTIDSSTIQRRGHTCRISTKLSCHYDKYPYIHKYDGDERQYSITAEGKCYKG
IKYEISMINDDTLLRKHTLKIGSTYIFDRHGHSNTYYSKYDF
Molecule Role Virulence factor
Molecule Role Annotation A virus deletion mutant lacking the B7R gene and a revertant virus were constructed. Compared to wild-type and revertant viruses, the deletion mutant replicated normally in cell culture and had unaltered virulence in a murine intranasal model of infection. However, the deletion mutant was attenuated in a murine intradermal model where it induced a smaller lesion than the control viruses. (Price et al., 2000)
References
Price et al., 2000: Price N, Tscharke DC, Hollinshead M, Smith GL. Vaccinia virus gene B7R encodes an 18-kDa protein that is resident in the endoplasmic reticulum and affects virus virulence. Virology. 2000; 267(1); 65-79. [PubMed: 10648184].