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A34R

Victor ID 5039
Gene Name A34R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707687
NCBI Protein GI 66275954
Locus Tag VACWR157
Genbank Accession JN654979
Protein Accession YP_233039
Taxonomy ID 10245
Gene Starting Position 143911
Gene Ending Position 144417
Gene Strand (Orientation) +
Protein Name IEV and EEV membrane glycoprotein
Protein pI 10.11
Protein Weight 18661.31
Protein Length 168
Protein Note IEV and EEV membrane glycoprotein; similar to vaccinia virus strain Copenhagen A34R; C-type lectin-like protein found on extracellular enveloped virions (EEV); The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins;
DNA Sequence 
>gi|66275797:143911-144417 Vaccinia virus, complete genome
AATGAAATCGCTTAATAGACAAACTGTAAGTAGGTTTAAGAAGTTGTCGGTGCCGGCCGCTATAATGATG
ATACTCTCAACCATTATTAGTGGCATAGGAACATTTCTGCATTACAAAGAAGAACTGATGCCTAGTGCTT
GCGCCAATGGATGGATACAATACGATAAACATTGTTATTTAGATACTAACATTAAAATGTCTACAGATAA
TGCGGTTTATCAGTGTCGTAAATTACGAGCCAGATTGCCTAGACCGGATACTAGACATCTGAGAGTATTG
TTTAGTATTTTTTATAAAGATTATTGGGTAAGTTTAAAAAAGACCAATGATAAATGGTTAGATATTAATA
ATGATAAAGATATAGATATTAGTAAATTAACAAATTTTAAACAACTAAACAGTACGACGGATGCTGAAGC
GTGTTATATATACAAGTCTGGAAAACTGGTTAAAACAGTATGTAAAAGTACTCAATCTGTACTATGTGTT
AAAAAATTCTACAAGTG
Protein Sequence 
>gi|66275954|ref|YP_233039.1| EEV glycoprotein [Vaccinia virus]
MKSLNRQTVSRFKKLSVPAAIMMILSTIISGIGTFLHYKEELMPSACANGWIQYDKHCYLDTNIKMSTDN
AVYQCRKLRARLPRPDTRHLRVLFSIFYKDYWVSLKKTNDKWLDINNDKDIDISKLTNFKQLNSTTDAEA
CYIYKSGKLVKTVCKSTQSVLCVKKFYK
Molecule Role Virulence factor
Molecule Role Annotation The WR delta A34R virus is highly attenuated in vivo compared with WR or a revertant virus in which the A34R gene was reinserted into WR delta A34R. (McIntosh and Smith, 1996)
References
McIntosh and Smith, 1996: McIntosh AA, Smith GL. Vaccinia virus glycoprotein A34R is required for infectivity of extracellular enveloped virus. Journal of virology. 1996; 70(1); 272-281. [PubMed: 8523536].