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A36R

Victor ID 5038
Gene Name A36R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707689
NCBI Protein GI 66275956
Locus Tag VACWR159
Genbank Accession X57318
Protein Accession YP_233041
Taxonomy ID 10245
Gene Starting Position 145058
Gene Ending Position 145723
Gene Strand (Orientation) +
Protein Name IEV transmembrane phosphoprotein
Protein pI 4.45
Protein Weight 23445.57
Protein Length 221
Protein Note similar to VACCP-A36R; interacts with A33R and used in actin tail formation
DNA Sequence 
>gi|66275797:145058-145723 Vaccinia virus, complete genome
AATGATGCTGGTACCTCTTATCACGGTGACCGTAGTTGCGGGAACAATATTAGTATGTTATATATTATAT
ATTTGTAGGAAAAAGATACGTACTGTCTATAATGACAATAAAATTATCATGACAAAATTAAAAAAGATAA
AGAGTTCTAATTCCAGCAAATCTAGTAAATCAACTGATAGCGAATCAGACTGGGAGGATCACTGTAGTGC
TATGGAACAAAACAATGACGTAGATAATATTTCTAGGAATGAGATATTGGACGATGATAGCTTCGCTGGT
AGTTTAATATGGGATAACGAATCCAATGTCATGGCGCCTAGCACAGAACACATTTACGATAGTGTTGCTG
GAAGCACGCTGCTAATAAATAATGATCGTAATGAACAGACTATTTATCAGAACACTACAGTAGTAATTAA
TGAGACGGAGACTGTTGAAGTACTTAATGAAGATACCAAACAGAATCCTAACTATTCATCCAATCCTTTC
GTAAATTATAATAAAACCAGTATTTGTAGCAAGTCAAATCCGTTCATTACAGAACTCAACAATAAATTTA
GTGAGAATAATCCGTTTAGACGAGCACATAGCGATGATTATCTTAATAAGCAAGAACAAGATCATGAACA
CGATGATATAGAATCATCGGTCGTATCATTGGTGTG
Protein Sequence 
>gi|66275956|ref|YP_233041.1| IEV transmembrane phosphoprotein [Vaccinia virus]
MMLVPLITVTVVAGTILVCYILYICRKKIRTVYNDNKIIMTKLKKIKSSNSSKSSKSTDSESDWEDHCSA
MEQNNDVDNISRNEILDDDSFAGSLIWDNESNVMAPSTEHIYDSVAGSTLLINNDRNEQTIYQNTTVVIN
ETETVEVLNEDTKQNPNYSSNPFVNYNKTSICSKSNPFITELNNKFSENNPFRRAHSDDYLNKQEQDHEH
DDIESSVVSLV
Molecule Role Virulence factor
Molecule Role Annotation Thus the loss of the A36R protein from the EEV surface did not reduce EEV specific infectivity in vitro. Despite this, delta A36R showed striking attenuation compared with WT in a murine intranasal model. (Parkinson and Smith, 1994)
References
Parkinson and Smith, 1994: Parkinson JE, Smith GL. Vaccinia virus gene A36R encodes a M(r) 43-50 K protein on the surface of extracellular enveloped virus. Virology. 1994; 204(1); 376-390. [PubMed: 8091668].