Victors

B5R
Victor ID	5037
Gene Name	B5R
Sequence Strain (Species/Organism)	Vaccinia virus
NCBI Gene ID	3707658
NCBI Protein GI	66275984
Locus Tag	VACWR187
Genbank Accession	A22016
Protein Accession	YP_233069
Taxonomy ID	10245
Gene Starting Position	168373
Gene Ending Position	169326
Gene Strand (Orientation)	+
Protein Name	EEV membrane glycoprotein
Protein pI	4.46
Protein Weight	32549.54
Protein Length	317
Protein Note	EEV membrane glycoprotein; similar to vaccinia virus strain Copenhagen B5R and cowpox virus B4R; glycoprotein found on extracellular enveloped virions (EEV); The poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins;
DNA Sequence	>gi\|66275797:168373-169326 Vaccinia virus, complete genome AATGAAAACGATTTCCGTTGTTACGTTGTTATGCGTACTACCTGCTGTTGTTTATTCAACATGTACTGTA CCCACTATGAATAACGCTAAATTAACGTCTACCGAAACATCGTTTAATGATAAACAGAAAGTTACGTTTA CATGTGATCAGGGATATCATTCTTCGGATCCAAATGCTGTCTGCGAAACAGATAAATGGAAATACGAAAA TCCATGCAAAAAAATGTGCACAGTTTCTGATTACATCTCTGAATTATATAATAAACCGCTATACGAAGTG AATTCCACCATGACACTAAGTTGCAACGGCGAAACAAAATATTTTCGTTGCGAAGAAAAAAATGGAAATA CTTCTTGGAATGATACTGTTACGTGTCCTAATGCGGAATGTCAACCTCTTCAATTAGAACACGGATCGTG TCAACCAGTTAAAGAAAAATACTCATTTGGGGAATATATGACTATCAACTGTGATGTTGGATATGAGGTT ATTGGTGCTTCGTACATAAGTTGTACAGCTAATTCTTGGAATGTTATTCCATCATGTCAACAAAAATGTG ATATGCCGTCTCTATCTAATGGATTAATTTCCGGATCTACATTTTCTATCGGTGGCGTTATACATCTTAG TTGTAAAAGTGGTTTTACACTAACGGGGTCTCCATCATCCACATGTATCGACGGTAAATGGAATCCCGTA CTCCCAATATGTGTACGAACTAACGAAGAATTTGATCCAGTGGATGATGGTCCCGACGATGAGACAGATT TGAGCAAACTCTCGAAAGACGTTGTACAATATGAACAAGAAATAGAATCGTTAGAAGCAACTTATCATAT AATCATAGTGGCGTTAACAATTATGGGCGTCATATTTTTAATCTCCGTTATAGTATTAGTTTGTTCCTGT GACAAAAATAATGACCAATATAAGTTCCATAAATTGCTACCGTA
Protein Sequence	>gi\|66275984\|ref\|YP_233069.1\| EEV type-I membrane glycoprotein [Vaccinia virus] MKTISVVTLLCVLPAVVYSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDQGYHSSDPNAVCETDKWKYEN PCKKMCTVSDYISELYNKPLYEVNSTMTLSCNGETKYFRCEEKNGNTSWNDTVTCPNAECQPLQLEHGSC QPVKEKYSFGEYMTINCDVGYEVIGASYISCTANSWNVIPSCQQKCDMPSLSNGLISGSTFSIGGVIHLS CKSGFTLTGSPSSTCIDGKWNPVLPICVRTNEEFDPVDDGPDDETDLSKLSKDVVQYEQEIESLEATYHI IIVALTIMGVIFLISVIVLVCSCDKNNDQYKFHKLLP
Molecule Role	Virulence factor
Molecule Role Annotation	only 10% of WT levels of EEV were produced by I-delta B5R. deletion of B5R had a profound affect on the formation of the extracellular enveloped virus (EEV). shown to form very small plaques compared with the wild-type viruses. (Engelstad and Smith, 1993)
References	Engelstad and Smith, 1993: Engelstad M, Smith GL. The vaccinia virus 42-kDa envelope protein is required for the envelopment and egress of extracellular virus and for virus virulence. Virology. 1993; 194(2); 627-637. [PubMed: 8503178].


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B5R