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M RNA segment

Victor ID 5036
Gene Name M RNA segment
Sequence Strain (Species/Organism) La Crosse virus
NCBI Gene ID 956555
NCBI Protein GI 22256026
Locus Tag LACVsMgp1
Genbank Accession AF528166
Protein Accession NP_671969
Taxonomy ID 11577
Segment No M
Gene Starting Position 61
Gene Ending Position 4386
Gene Strand (Orientation) +
Protein Name G1/G2 membrane polyprotein
Protein pI 7.74
Protein Weight 153628.67
Protein Length 1441
DNA Sequence 
>gi|22256025:61-4386 La Crosse virus segment M, complete genome
GATGATTTGTATATTGGTGCTAATTACAGTTGCAGCTGCAAGCCCAGTGTATCAAAGGTGTTTCCAAGAT
GGGGCTATAGTGAAGCAAAACCCATCCAAAGAAGCAGTTACAGAGGTGTGCCTGAAAGATGATGTTAGCA
TGATCAAAACAGAGGCCAGGTATGTAAGAAATGCAACAGGAGTTTTTTCAAATAATGTCGCAATAAGGAA
ATGGCTAGTCTCTGATTGGCATGATTGCAGGCCTAAGAAGATCGTTGGGGGACACATCAATGTAATAGAA
GTTGGTGATGACCTGTCACTCCATACTGAATCATATGTTTGCAGCGCAGATTGTACCATAGGTGTAGACA
AAGAGACTGCACAGGTCAGGCTTCAGACAGATACCACAAATCATTTTGAAATTGCAGGCACTACTGTGAA
GTCAGGATGGTTCAAGAGCACGACATATATAACTCTTGATCAAACTTGCGAACACCTTAAAGTTTCCTGC
GGCCCAAAATCTGTACAGTTCCATGCCTGCTTCAATCAGCATATGTCTTGCGTCAGATTTTTACACAGGA
CAATATTGCCTGGCTCTATAGCCAATTCCATATGTCAGAATATCGAAATCATAATTTTAGTTACACTTAC
TCTATTAATCTTTATATTGTTAAGCATTTTAAGTAAGACTTATATATGTTATTTATTAATGCCTATATTC
ATCCCCATAGCATATATATACGGTATAATTTACAATAAGTCGTGCAAAAAATGCAAATTATGTGGCTTAG
TGTATCATCCATTCACAGAGTGTGGCACACATTGTGTCTGTGGTGCCCGCTATGATACTTCAGATAGAAT
GAAACTGCATAGAGCTTCTGGATTGTGCCCTGGTTATAAAAGCCTAAGAGCTGCCAGAGTCATGTGCAAG
TCGAAAGGGCCTGCATCAATATTGTCTATAATTACTGCGGTACTGGTCTTAACCTTTGTGACACCAATCA
ACTCCATGGTTTTAGGAGAGAGTAAAGAAACCTTTGAACTTGAAGATCTTCCAGACGACATGTTGGAAAT
GGCATCGAGAATAAATTCTTATTATCTCACCTGTATCTTGAATTATGCTGTAAGCTGGGGTCTTGTTATC
ATTGGATTGTTGATCGGGCTGCTTTTTAAGAAATACCAGCACAGATTCTTAAATGTTTACGCAATGTACT
GTGAAGAATGTGACATGTATCATGACAAGTCTGGGTTGAAAAGACATGGTGATTTCACCAACAAATGCAG
ACAGTGCACATGTGGTCAATATGAAGATGCTGCAGGTTTGATGGCTCACAGGAAAACCTATAACTGCTTA
GTGCAGTACAAAGCAAAGTGGATGATGAACTTCCTGATAATTTACATATTCTTAATTTTGATCAAAGATT
CTGCTATAGTTGTACAAGCTGCTGGAACTGACTTCACCACCTGCCTAGAGACTGAGAGTATAAATTGGAA
CTGCACTGGGCCATTTTTGAACCTCGGGAATTGCCAAAAGCAACAAAAGAAAGAACCTTACACCAACATT
GCAACTCAGTTAAAGGGACTAAAGGCAATTTCCGTACTAGATGTCCCTATAATAACAGGGATACCAGATG
ATATTGCGGGTGCTTTAAGATATATAGAAGAGAAGGAAGATTTCCATGTCCAGCTAACTATAGAATATGC
GATGTTAAGCAAATACTGTGACTATTATACCCAATTCTCAGATAACTCAGGATACAGTCAGACAACATGG
AGAGTGTACTTAAGGTCTCATGATTTTGAAGCCTGTATACTATATCCAAATCAGCACTTTTGCAGATGTG
TAAAAAATGGTGAGAAGTGCAGCAGCTCCAATTGGGACTTTGCCAATGAAATGAAAGATTATTACTCTGG
GAAACAAACAAAGTTTGACAAGGACTTAAATCTAGCCCTAACAGCTTTGCATCATGCCTTCAGGGGGACC
TCATCTGCATATATAGCAACAATGCTCTCAAAAAAGTCCAATGATGACTTGATTGCATACACAAATAAGA
TAAAAACAAAATTCCCAGGTAATGCATTGTTGAAGGCTATAATAGATTATATAGCATATATGAAAAGTTT
GCCAGGTATGGCAAATTTCAAATATGATGAATTCTGGGATGAATTACTGTACAAACCCAACCCAGCAAAG
GCCTCAAACCTTGCTAGAGGAAAGGAGTCATCTTACAACTTCAAACTAGCAATTTCATCAAAGTCTATAA
AAACCTGCAAGAATGTTAAGGATGTTGCCTGCTTATCGCCAAGGTCAGGTGCTATATATGCTTCAATAAT
TGCGTGTGGTGAACCCAATGGGCCAAGTGTGTATAGGAAACCATCAGGTGGTGTATTCCAATCTAGCACT
GATCGGTCTATATACTGCTTGCTGGATAGCCATTGTCTAGAAGAATTTGAGGCCATCGGCCAGGAGGAGC
TGGATGCGGTAAAGAAATCCAAATGTTGGGAAATTGAATATCCTGACGTAAAGCTCATCCAAGAAGGCGA
TGGGACTAAAAGCTGTAGAATGAAAGATTCTGGGAACTGCAATGTTGCAACTAACAGATGGCCAGTGATA
CAATGTGAGAATGACAAATTTTACTACTCAGAGCTTCAAAAAGATTATGACAAAGCTCAAGATATTGGTC
ACTATTGCTTAAGCCCTGGATGTACTACTGTCCGGTACCCTATTAATCCAAAGCACATCTCTAACTGTAA
TTGGCAAGTAAGCAGATCTAGCATAGCGAAGATAGATGTGCACAATATTGAGGATATTGAGCAATATAAG
AAAGCTATAACTCAGAAACTTCAAACGAGCCTATCTCTATTCAAGTATGCAAAAACAAAAAACTTGCCGC
ACATCAAACCAATTTATAAATATATAACTATAGAAGGAACAGAAACTGCAGAAGGTATAGAGAGTGCATA
CATTGAATCAGAAGTACCTGCATTGGCTGGGACATCTATCGGATTCAAAATCAATTCTAAAGAGGGCAAG
CACTTGCTAGATGTTATAGCATATGTAAAAAGTGCCTCATACTCTTCAGTGTATACAAAATTGTACTCAA
CTGGCCCAACATCAGGGATAAATACTAAACATGATGAATTGTGTACTGGCCCATGCCCAGCAAATATCAA
TCATCAGGTTGGGTGGCTGACATTTGCAAGAGAGAGGACAAGCTCATGGGGATGCGAAGAGTTTGGTTGC
CTGGCTGTAAGTGATGGGTGTGTATTTGGATCATGCCAAGATATAATAAAAGAAGAACTATCTGTCTATA
GGAAGGAGACCGAGGAAGTGACTGATGTAGAACTGTGTTTGACATTTTCAGACAAAACATACTGTACAAA
CTTAAACCCTGTTACCCCTATTATAACAGATCTATTTGAGGTACAGTTCAAAACTGTAGAGACCTACAGC
TTGCCTAGAATTGTTGCTGTGCAAAACCATGAGATTAAAATTGGGCAAATAAATGATTTAGGAGTTTACT
CTAAGGGTTGTGGGAATGTTCAAAAGGTCAATGGAACTATTTATGGCAATGGAGTTCCCAGATTTGACTA
CTTATGCCATTTAGCTAGCAGGAAGGAAGTCATTGTTAGAAAATGCTTCGACAATGATTACCAAGCATGC
AAATTTCTTCAAAGCCCTGCTAGTTACAGACTTGAAGAAGACAGTGGCACTGTGACCATAATTGACTACA
AAAAGATTTTAGGAACAATCAAGATGAAGGCAATTTTAGGAGATGTCAAATATAAAACATTTGCTGATAG
TGTCGATATAACCGCAGAAGGGTCATGCACCGGCTGTATTAACTGCTTCGAAAATATCCATTGCGAATTA
ACGTTGCACACCACAATTGAAGCCAGCTGCCCAATTAAAAGCTCGTGCACAGTATTTCATGACAGGATTC
TTGTGACTCCAAATGAACACAAATATGCATTGAAAATGGTGTGCACAGAAAAGCCAGGGAACACACTCAC
AATTAAAGTCTGCAATACTAAAGTTGAAGCATCTATGGCCCTTGTAGACGCAAAGCCTATCATAGAACTA
GCACCAGTTGATCAGACAGCATATATAAGAGAAAAAGATGAAAGGTGTAAAACTTGGATGTGTAGGGTAA
GAGATGAAGGACTGCAGGTCATCTTGGAGCCATTTAAAAATTTATTTGGATCTTATATTGGGATATTTTA
CACATTTATTATATCTATAGTAGTATTATTGGTTATTATCTATGTACTACTACCTATATGCTTTAAGTTA
AGGGATACCCTTAGAAAGCATGAAGATGCATATAAGAGAGAGATGAAAATTAGATA
Protein Sequence 
>gi|22256026|ref|NP_671969.1| G1/G2 membrane polyprotein [La Crosse virus]
MICILVLITVAAASPVYQRCFQDGAIVKQNPSKEAVTEVCLKDDVSMIKTEARYVRNATGVFSNNVAIRK
WLVSDWHDCRPKKIVGGHINVIEVGDDLSLHTESYVCSADCTIGVDKETAQVRLQTDTTNHFEIAGTTVK
SGWFKSTTYITLDQTCEHLKVSCGPKSVQFHACFNQHMSCVRFLHRTILPGSIANSICQNIEIIILVTLT
LLIFILLSILSKTYICYLLMPIFIPIAYIYGIIYNKSCKKCKLCGLVYHPFTECGTHCVCGARYDTSDRM
KLHRASGLCPGYKSLRAARVMCKSKGPASILSIITAVLVLTFVTPINSMVLGESKETFELEDLPDDMLEM
ASRINSYYLTCILNYAVSWGLVIIGLLIGLLFKKYQHRFLNVYAMYCEECDMYHDKSGLKRHGDFTNKCR
QCTCGQYEDAAGLMAHRKTYNCLVQYKAKWMMNFLIIYIFLILIKDSAIVVQAAGTDFTTCLETESINWN
CTGPFLNLGNCQKQQKKEPYTNIATQLKGLKAISVLDVPIITGIPDDIAGALRYIEEKEDFHVQLTIEYA
MLSKYCDYYTQFSDNSGYSQTTWRVYLRSHDFEACILYPNQHFCRCVKNGEKCSSSNWDFANEMKDYYSG
KQTKFDKDLNLALTALHHAFRGTSSAYIATMLSKKSNDDLIAYTNKIKTKFPGNALLKAIIDYIAYMKSL
PGMANFKYDEFWDELLYKPNPAKASNLARGKESSYNFKLAISSKSIKTCKNVKDVACLSPRSGAIYASII
ACGEPNGPSVYRKPSGGVFQSSTDRSIYCLLDSHCLEEFEAIGQEELDAVKKSKCWEIEYPDVKLIQEGD
GTKSCRMKDSGNCNVATNRWPVIQCENDKFYYSELQKDYDKAQDIGHYCLSPGCTTVRYPINPKHISNCN
WQVSRSSIAKIDVHNIEDIEQYKKAITQKLQTSLSLFKYAKTKNLPHIKPIYKYITIEGTETAEGIESAY
IESEVPALAGTSIGFKINSKEGKHLLDVIAYVKSASYSSVYTKLYSTGPTSGINTKHDELCTGPCPANIN
HQVGWLTFARERTSSWGCEEFGCLAVSDGCVFGSCQDIIKEELSVYRKETEEVTDVELCLTFSDKTYCTN
LNPVTPIITDLFEVQFKTVETYSLPRIVAVQNHEIKIGQINDLGVYSKGCGNVQKVNGTIYGNGVPRFDY
LCHLASRKEVIVRKCFDNDYQACKFLQSPASYRLEEDSGTVTIIDYKKILGTIKMKAILGDVKYKTFADS
VDITAEGSCTGCINCFENIHCELTLHTTIEASCPIKSSCTVFHDRILVTPNEHKYALKMVCTEKPGNTLT
IKVCNTKVEASMALVDAKPIIELAPVDQTAYIREKDERCKTWMCRVRDEGLQVILEPFKNLFGSYIGIFY
TFIISIVVLLVIIYVLLPICFKLRDTLRKHEDAYKREMKIR
Molecule Role Virulence factor
Molecule Role Annotation A comparative pathogenesis study in suckling mice of one reassortant virus and the parent Tahyna virus confirmed the greater neuroinvasiveness of the reassortant virus. From these data it was concluded that the M RNA segment was the major determinant of virulence. (Janssen et al., 1986)
References
Janssen et al., 1986: Janssen RS, Nathanson N, Endres MJ, Gonzalez-Scarano F. Virulence of La Crosse virus is under polygenic control. Journal of virology. 1986; 59(1); 1-7. [PubMed: 3712554].