Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

VGF

Victor ID 5035
Gene Name VGF
Sequence Strain (Species/Organism) Cowpox virus
NCBI Gene ID 1485896
NCBI Protein GI 20178389
Locus Tag CPXV021
Genbank Accession AF482758
Protein Accession NP_619810
Taxonomy ID 10243
Gene Starting Position 23742
Gene Ending Position 24161
Gene Strand (Orientation) +
Protein Name CPXV021 protein or CPXV VGF protein
Protein pI 6.87
Protein Weight 14685.96
Protein Length 139
Protein Note Also known as CPXV021
DNA Sequence 
>gi|30844336:23742-24161 Cowpox virus, complete genome
AATGTCGATGAAATATCTGATGTTGTTGTTCGCTGCTATGATAATCAGATCATTCGCCGATAGTGGTAAC
GCTATCGAAACGACATCGCCAGAAATTACAAACGCTACAACAGATATTCCAGCTATCAGATTATGCGGTC
CAGAGGGAGATGGATATTGTTTACACGGTGACTGTATCCACGCTAGAGATATCGACGGTATGTATTGTAG
ATGCTTTCATGGTTATATTGGTATTAGATGTCAGCATATAGTATTAGTAGACTATCAACGTTCAGAAAAA
CCAGACACTACAACATCATATATCCCATCTCCAGGTATTGTGCTTGTATTAGTAGGCATTATTATTACGT
GTTGTCTATTATCTGTTTATAGGTTCACTCGAAGAACTAAACTACCTCTACAAGATATGGTTGTGCCATA
Protein Sequence 
>gi|20178389|ref|NP_619810.1| CPXV021 protein or CPXV VGF protein [Cowpox virus]
MSMKYLMLLFAAMIIRSFADSGNAIETTSPEITNATTDIPAIRLCGPEGDGYCLHGDCIHARDIDGMYCR
CFHGYIGIRCQHIVLVDYQRSEKPDTTTSYIPSPGIVLVLVGIIITCCLLSVYRFTRRTKLPLQDMVVP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Higher doses of VGF- virus than WT virus were required for intracranial lethality in mice and for production of skin lesions in rabbits. Thus, expression of the VGF gene is important to the virulence of vaccinia virus (Buller et al., 1988).
References
Buller et al., 1988: Buller RM, Chakrabarti S, Cooper JA, Twardzik DR, Moss B. Deletion of the vaccinia virus growth factor gene reduces virus virulence. Journal of virology. 1988; 62(3); 866-874. [PubMed: 3339716].