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US8

Victor ID 5032
Gene Name US8
Sequence Strain (Species/Organism) Suid herpesvirus 1
NCBI Gene ID 2952517
NCBI Protein GI 51557555
Locus Tag SuHV1_gp70
Genbank Accession AY368490
Protein Accession YP_068389
Taxonomy ID 10345
Gene Starting Position 123451
Gene Ending Position 125731
Gene Strand (Orientation) +
Protein Name envelope glycoprotein E
Protein pI 4.61
Protein Weight 57747.49
Protein Length 577
Protein Note gE family
DNA Sequence 
>gi|51557483:123451-125731 Suid herpesvirus 1, complete genome
GTTTTAAACCTGGGCACCCCCGCGAGTCTCGCACACACCGGGGTTGAGACCATGCGGCCCTTTCTGCTGC
GCGCCGCGCAGCTCCTGGCGCTGCTGGCCCTGGCGCTCTCCACCGAGGCCCCGAGCCTCTCCGCCGAGAC
GACCCCGGGCCCCGTCACCGAGGTCCCGAGTCCCTCGGCCGAGGTCTGGGACCTCTCCACCGAGGCCGGC
GACGATGACCTCGACGGCGACCTCAACGGCGACGACCGCCGCGCGGGCTTCGGCTCGGCCCTCGCCTCCC
TGAGGGAGGCACCCCCGGCCCATCTGGTGAACGTGTCCGAGGGCGCCAACTTCACCCTCGACGCGCGCGG
CGACGGCGCCGTGGTGGCCGGGATCTGGACGTTCCTGCCCGTCCGCGGCTGCGACGCCGTGGCGGTGACC
ATGGTGTGCTTCGAGACCGCCTGCCACCCGGACCTGGTGCTGGGCCGCGCCTGCGTCCCCGAGGCCCCGG
AGCGGGGCATCGGCGACTACCTGCCGCCCGAGGTGCCGCGGCTCCAGCGCGAGCCGCCCATCGTCACCCC
GGAGCGGTGGTCGCCGCACCTGACCGTCCGGCGGGCCACGCCCAACGACACGGGCCTCTACACGCTGCAC
GACGCCTCGGGGCCGCGGGCCGTGTTCTTTGTGGCGGTGGGCGACCGGCCGCCCGCGCCGCTGGCCCCGG
TGGGCCCCGCGCGCCACGAGCCCCGCTTCCACGCGCTCGGCTTCCACTCGCAGCTCTTCTCGCCCGGGGA
CACGTTCGACCTGATGCCGCGCGTGGTCTCGGACATGGGCGACTCGCGCGAGAACTTCACCGCCACGCTG
GACTGGTACTACGCGCGCGCGCCCCCGCGGTGCCTGCTGTACTACGTGTACGAGCCCTGCATCTACCACC
CGCGCGCGCCCGAGTGCCTGCGCCCGGTGGACCCGGCGTGCAGCTTCACCTCGCCGGCGCGCGCGCGGCT
GGTGGCGCGCCGCGCGTACGCCTCGTGCAGCCCGCTGCTCGGGGACCGGTGGCTGACCGCCTGCCCCTTC
GACGCCTTCGGCGAGGAGGTGCACACGAACGCCACCGCGGACGAGTCGGGGCTGTACGTGCTCGTGATGA
CCCACAACGGCCACGTCGCCACCTGGGACTACACGCTCGTCGCCACCGCGGCCGAGTACGTCACGGTCAT
CAAGGAGCTGACGGCCCCGGCCCGGGCCCCGGGCACCCCGTGGGGCCCCGGCGGCGGCGACGACGCGATC
TACGTGGACGGCGTCACGACGCCGGCGCCGCCCGCGCGCCCGTGGAACCCGTACGGCCGGACGACGCCCG
GGCGGCTGTTTGTGCTGGCGCTGGGCTCCTTCGTGATGACGTGCGTCGTCGGGGGGGCCGTCTGGCTCTG
CGTGCTGTGCTCCCGCCGCCGGGCGGCCTCGCGGCCGTTCCGGGTGCCGACGCGGGCGGGGACGCGCATG
CTCTCGCCGGTGTACACCAGCCTGCCCACGCACGAGGACTACTACGACGGCGACGACGACGACGAGGAGG
CGGGCGACGCCCGCCGGCGGCCCTCCTCCCCCGGCGGGGACAGCGGCTACGAGGGGCCGTACGTGAGCCT
GGACGCCGAGGACGAGTTCAGCAGCGACGAGGACGACGGGCTGTACGTGCGCCCCGAGGAGGCGCCCCGC
TCCGGCTTCGACGTCTGGTTCCGCGATCCGGAGAAACCGGAAGTGACGAATGGGCCCAACTATGGCGTGA
CCGCCAGCCGCCTGTTGAATGCCCGCCCCGCTTAAATACCGGGAGAACCGGCCCGCCCGCATTCCGACAT
GCCCGCCGCCGCCCCCGCCGACATGGACACGTTCGACCCCAGCGCCCCCGTCCCGACGAGCGTCTCTAAC
CCGGCCGCCGACGTCCTGCTGGCCCCCAAGGGACCCCGCTCCCCGCTGCGCCCCCAGGACGACTCGGACT
GCTACTACAGCGAGAGCGACAACGAGACGCCCAGCGAGTTCCTGCGCCGCGTGGGACGCCGGCAGGCGGC
GCGCCGGAGACGCCGCCGCTGCCTGATGGGCGTCGCGATCAGCGCCGCCGCGCTGGTCATCTGCTCGCTG
TCGGCGCTGATCGGGGGCATCATCGCCCGGCACGTGTAGCGAGCGGGTGGTGGCCGCCCGCCCCGCCGCG
CCCAGGAGGGGGGGTCCGGGGGGGCGAAGCGGGCGGAGGAGAGCGAGCCACGTGGTTGTGGGCTCGGACT
TGTCACAATAAATGGGCCCCGGCGCACCCGGGCGCACACAG
Protein Sequence 
>gi|51557555|ref|YP_068389.1| envelope glycoprotein E [Suid herpesvirus 1]
MRPFLLRAAQLLALLALALSTEAPSLSAETTPGPVTEVPSPSAEVWDLSTEAGDDDLDGDLNGDDRRAGF
GSALASLREAPPAHLVNVSEGANFTLDARGDGAVVAGIWTFLPVRGCDAVAVTMVCFETACHPDLVLGRA
CVPEAPERGIGDYLPPEVPRLQREPPIVTPERWSPHLTVRRATPNDTGLYTLHDASGPRAVFFVAVGDRP
PAPLAPVGPARHEPRFHALGFHSQLFSPGDTFDLMPRVVSDMGDSRENFTATLDWYYARAPPRCLLYYVY
EPCIYHPRAPECLRPVDPACSFTSPARARLVARRAYASCSPLLGDRWLTACPFDAFGEEVHTNATADESG
LYVLVMTHNGHVATWDYTLVATAAEYVTVIKELTAPARAPGTPWGPGGGDDAIYVDGVTTPAPPARPWNP
YGRTTPGRLFVLALGSFVMTCVVGGAVWLCVLCSRRRAASRPFRVPTRAGTRMLSPVYTSLPTHEDYYDG
DDDDEEAGDARRRPSSPGGDSGYEGPYVSLDAEDEFSSDEDDGLYVRPEEAPRSGFDVWFRDPEKPEVTN
GPNYGVTASRLLNARPA
Molecule Role Virulence factor
Molecule Role Annotation Pigs immunized with M30, lacked amino acids valine (125) and cysteine(126) in an immunodominant antigenic region of glycoprotein I, were completely protected against challenge infection; no clinical signs of disease were detected, no virus was shed, and no secondary antibody response was detected. (Jacobs et al., 1993)
References
Jacobs et al., 1993: Jacobs L, Mulder WA, Van Oirschot JT, Gielkens AL, Kimman TG. Deleting two amino acids in glycoprotein gI of pseudorabies virus decreases virulence and neurotropism for pigs, but does not affect immunogenicity. The Journal of general virology. 1993; 74 ( Pt 10); 2201-2206. [PubMed: 8409943].