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VACVgp007

Victor ID 5029
Gene Name VACVgp007
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 1486315
NCBI Protein GI 9790910
Locus Tag VACVgp007
Protein Accession NP_063637
Taxonomy ID 10245
Gene Starting Position 6473
Gene Ending Position 6814
Gene Strand (Orientation) -
Protein Name Hypothetical protein
Protein pI 7.57
Protein Weight 12610.66
Protein Length 113
DNA Sequence 
>gi|9790357:6473-6814 Vaccinia virus, complete genome
CTTATGTCACGATGATGGAATCTATCTTATCGAATGATATATTTTTCATAAATACACTTTTATAGTCCTC
GTTTAAACAGAATTTACTATGTAGTTCCGCGAATGACTCGTCCCTTAATAGGCAGTAGGCTAGTATCTTT
TTTACGTAGTAATCGTCGTAGGGAGAGAATTCTGACATCTTGTAGAACAACGATTTAATCATAGGTAGAG
ATACTTTCAGTCTGTGGTGGATGATGTCATTCACAACATCCGCCTTGTATATGATGTTTCTGTTTTCAAA
CACCAAGTCGAATACCGTCTTTAGTCGGAAGGTTGATGTCGTATCCGATGTATGAGGCAACA
Protein Sequence 
>gi|9790910|ref|NP_063637.1| Hypothetical protein [Vaccinia virus]
MLPHTSDTTSTFRLKTVFDLVFENRNIIYKADVVNDIIHHRLKVSLPMIKSLFYKMSEFSPYDDYYVKKI
LAYCLLRDESFAELHSKFCLNEDYKSVFMKNISFDKIDSIIVT
Molecule Role Virulence factor
Molecule Role Annotation Skin lesions caused by the C21L deletion mutant were smaller than those caused by wild-type virus, demonstrating an important role for VCP in virulence. The C21L deletion mutant also was attenuated in C4-deficient guinea pigs. (Isaacs et al., 1992)
References
Isaacs et al., 1992: Isaacs SN, Kotwal GJ, Moss B. Vaccinia virus complement-control protein prevents antibody-dependent complement-enhanced neutralization of infectivity and contributes to virulence. Proceedings of the National Academy of Sciences of the United States of America. 1992; 89(2); 628-632. [PubMed: 1731333].