Arginine instead of serine at position 114 of the mature E2 glycoprotein, distinguished the prototype attenuated mutant from its virulent wild-type parent. (Davis et al., 1986)
References
Davis et al., 1986: Davis NL, Fuller FJ, Dougherty WG, Olmsted RA, Johnston RE. A single nucleotide change in the E2 glycoprotein gene of Sindbis virus affects penetration rate in cell culture and virulence in neonatal mice. Proceedings of the National Academy of Sciences of the United States of America. 1986; 83(18); 6771-6775. [PubMed: 3462725].
