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phoP

Victor ID 5016
Gene Name phoP
Sequence Strain (Species/Organism) Yersinia pseudotuberculosis IP 32953
NCBI Gene ID 2956268
NCBI Protein GI 51596756
Locus Tag YPTB2434
Genbank Accession BX936398
Protein Accession YP_070947
Taxonomy ID 273123
Gene Starting Position 2877188
Gene Ending Position 2877859
Gene Strand (Orientation) +
Protein Name DNA-binding transcriptional regulator PhoP
Protein pI 5.6
Protein Weight 23966.83
Protein Length 223
Protein Note response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
DNA Sequence 
>gi|51594359:2877188-2877859 Yersinia pseudotuberculosis IP 32953, complete genome
TATGCGGGTTCTGGTTGTGGAAGATAACGCGTTGTTGCGTCACCATCTGACAGTGCAAATGCGTGAAATG
GGCCATCAGGTTGATGCCGCGGAAGATGCTAAAGAAGCAGACTATTTCTTACAAGAGCATGCCCCCGACA
TTGCTATTATCGATCTTGGTTTGCCCGGTGAAGACGGGTTAAGCCTTATCCGTCGCTGGCGTAGCCATCA
AGAAAACTTACCCATTTTGGTCCTGACCGCACGGGAAAGCTGGCAAGATAAAGTCGCTGTACTGGAAGCC
GGTGCCGACGATTATGTGACCAAACCGTTCCATCTGGAAGAGGTCATTGCCCGGATGCAAGCACTGATGC
GGCGGAATATTGGCCTGGCCTCCCAAATTATTGAGCTACCGCCCTTCCAGATTGACCTTTCACGCCGTGA
GTTATGTGTTAACCAACAACAAATTAAACTGACGGCATTTGAATACACTATCATTGAAACCCTTATCCGC
AACGCAGGGAAAGTCGTTAGTAAGGATACGTTGATGCTACAACTTTATCCGGATGCGGAATTGCGAGAGA
GCCATACTATCGATGTATTAATGGGTCGACTACGTAAAAAACTGCTGGCAGAACATCAGGGTGAAGTCAT
TACGACTATTCGTGGTCAGGGATATCGTTTTGACGTCAACTA
Protein Sequence 
>gi|51596756|ref|YP_070947.1| DNA-binding transcriptional regulator PhoP [Yersinia pseudotuberculosis IP 32953]
MRVLVVEDNALLRHHLTVQMREMGHQVDAAEDAKEADYFLQEHAPDIAIIDLGLPGEDGLSLIRRWRSHQ
ENLPILVLTARESWQDKVAVLEAGADDYVTKPFHLEEVIARMQALMRRNIGLASQIIELPPFQIDLSRRE
LCVNQQQIKLTAFEYTIIETLIRNAGKVVSKDTLMLQLYPDAELRESHTIDVLMGRLRKKLLAEHQGEVI
TTIRGQGYRFDVN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A phoP mutant in Yersinia pseudotuberculosis (Yptb) was attenuated in mice (Balada-Llasat et al., 2007).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Balada-Llasat et al., 2007: Balada-Llasat JM, Panilaitis B, Kaplan D, Mecsas J. Oral inoculation with Type III secretion mutants of Yersinia pseudotuberculosis provides protection from oral, intraperitoneal, or intranasal challenge with virulent Yersinia. Vaccine. 2007; 25(8); 1526-1533. [PubMed: 17194509].