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PE2

Victor ID 5011
Gene Name PE2
Sequence Strain (Species/Organism) Venezuelan equine encephalitis virus
NCBI Protein GI 229558446
Other Database IDs CDD:190039
CDD:109978
Taxonomy ID 11036
Gene Strand (Orientation) ?
Protein Name PE2
Protein Length 272
Protein Note Alphavirus E3 glycoprotein; pfam01563
Protein Sequence 
>gi|229558446|gb|ACQ76875.1| PE2 [Venezuelan equine encephalitis virus]
LVTTMCLLANVTFPCAQPPICYDRKPAETLAMLSVNVDNPGYDELLEAAVKCPGRKRRSTEELFKEYKLT
RPYMARCIRCAVGSCHSPIAIEAVKSDGHDGYVRLQTSSQYGLDSSGNLKGRTMRYDMHGTIEEIPLHQV
SLHTSRPCHIVDGHGYFLLARCPAGDSITMEFKKDSVTHSCSVPYEVKFNPVGRELYTHPPEHGAEQACQ
VYAHDAQNRGAYVEMHLPGSEVDSSLVSLSGSSVTVTPPAGTSALVECECGGTKISETINTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A VEE mutant with a PE2 cleavage signal mutation and a suppressor mutation in E1 is highly attenuated in mice (Davis et al., 1995).
References
Davis et al., 1995: Davis NL, Brown KW, Greenwald GF, Zajac AJ, Zacny VL, Smith JF, Johnston RE. Attenuated mutants of Venezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. Virology. 1995; 212(1); 102-110. [PubMed: 7676619].