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virK from Shigella flexneri 5a

Victor ID 50
Gene Name virK from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876530
NCBI Protein GI 13449190
Locus Tag pWR501_p251
Protein Accession NP_085406.1
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 184994
Gene Ending Position 185944
Gene Strand (Orientation) +
Protein Name virulence protein
DNA Sequence 
>gi|13448939:184994-185944 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
TATGTTTTCTGTAAGTAACTTATCATTTATCGGTTTCCTTAAAAGGATTGTTTTTTCCTCAGATTCACTC
CCGGGGAAGTGGGAACACAGAAAATTCCGGTTCATGTACATTTTGCGATGTGCTATAAATCCGGTTGCCA
GTATTCGATATTATTACGAACTGCGTTCCTTGCAGTGCATTGAGGATATTCTGGCAATACAACCCACGTT
GCCAGCAAGAATTCATCGACCTTATTTGCATAAAGGGGGGCGAGCCTGGTCCCGGGGGCAATATATTCTT
GAGCATTATCGCTTTGTGCAAAATTTGCCAGAAAAATATTCTGAATTTTTGTTTCCACAAAAATCGGTAT
CATTAGTCCAATTCATCGGGAAAGATGGAGAGGATTTTGATATCCAGTGTTCTCCCAGTGGTTTTGACCG
GGAAGGAGAGTTGATGTTGTCATTGTTTTTCAATAAAATAGTGATTGCCCGGTTAACATTTTCAGTCATT
CTGACTCAAAATGGACACACCGCTTTTATTGGCGGATTACAGGGAGCCCCCAAAAATACCGGACCTGATG
TTATTCGGTGCGCAACCCGGGCCTGTTATGGGCTTTTCCCAAAACGGATTATTTTTGAAGCATTTTGTGC
GTTGATGAAAGCTTGTAATGTCTCTGAGTGTCTGGCAGTCAGTGAGCACAGTCATGTTTTCCGGCAATTG
AGATACTGGTATCAGAAACGCAAAACCTTTGTTGCTGTCTACAGTGATTTCTGGGAGTCTGTAGCAGGGA
AAACCTGTGGTGACTGGTACAAATTACCAACACAGGTGGTTCGAAAGCCGCTAAGCAATATAGCTAGTAA
AAAACGCTCTGAGTATCGAAAACGATACGCTTTGCTGGATTATATCCATGAAACTGCTATCCGCTCTTTG
GATGCATATCCTGTAAACTCAGAACATCAGGACTTAAATTA
Protein Sequence 
>gi|13449190|ref|NP_085406.1| virulence protein [Shigella flexneri 5a str. M90T] MFSVSNLSFIGFLKRIVFSSDSLPGKWEHRKFRFMYILRCAINPVASIRYYYELRSLQCIEDILAIQPTLPARIHRPYLHKGGRAWSRGQYILEHYRFVQNLPEKYSEFLFPQKSVSLVQFIGKDGEDFDIQCSPSGFDREGELMLSLFFNKIVIARLTFSVILTQNGHTAFIGGLQGAPKNTGPDVIRCATRACYGLFPKRIIFEAFCALMKACNVSECLAVSEHSHVFRQLRYWYQKRKTFVAVYSDFWESVAGKTCGDWYKLPTQVVRKPLSNIASKKRSEYRKRYALLDYIHETAIRSLDAYPVNSEHQDLN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: virK mutants have attenuated ability for intracellular spreading in host cells (Wing et al., 2005).
References
Wing et al., 2005: Wing HJ, Goldman SR, Ally S, Goldberg MB. Modulation of an outer membrane protease contributes to the virulence defect of Shigella flexneri strains carrying a mutation in the virK locus. Infection and immunity. 2005; 73(2); 1217-1220. [PubMed: 15664968].