Victors

UL23
Victor ID	4997
Gene Name	UL23
Sequence Strain (Species/Organism)	Suid herpesvirus 1
NCBI Gene ID	2952559
NCBI Protein GI	51557518
Locus Tag	SuHV1_gp35
Genbank Accession	BK001744
Protein Accession	YP_068352
Taxonomy ID	10345
Gene Starting Position	59511
Gene Ending Position	60589
Gene Strand (Orientation)	+
Protein Name	thymidine kinase
Protein pI	7.14
Protein Weight	32400.33
Protein Length	320
Protein Note	2.7.1.21
DNA Sequence	>gi\|51557483:59511-60589 Suid herpesvirus 1, complete genome GATGCGCATCCTCCGGATCTACCTCGACGGCGCCTACGGCACCGGCAAGAGCACCACTGCCCGGGTGATG GCGCTCGGCGGGGCGCTGTACGTGCCCGAGCCGATGGCGTACTGGCGCACTCTGTTCGACACGGACACGG TGGCCGGTATTTACGATGCGCAGACCCGGAAGCAGAACGGCAGCCTGAGCGAGGAGGACGCGGCCCTCGT CACGGCGCAGCACCAGGCCGCCTTCGCGACGCCGTACCTGCTGCTGCACACGCGCCTGGTCCCGCTCTTC GGGCCCGCGGTCGAGGGCCCGCCCGAGATGACGGTCGTCTTTGACCGCCACCCGGTGGCCGCGACGGTGT GCTTCCCGCTGGCGCGCTTCATCGTCGGGGACATCAGCGCGGCGGCCTTCGTGGGCCTGGCGGCCACGCT GCCCGGGGAGCCCCCCGGCGGCAACCTGGTGGTGGCCTCGCTGGACCCGGACGAGCACCTGCGGCGCCTG CGCGCCCGCGCGCGCGCCGGGGAGCACGTGGACGCGCGCCTGCTCACGGCCCTGCGCAACGTCTACGCCA TGCTGGTCAACACGTCGCGCTACCTGAGCTCGGGGCGCCGCTGGCGCGACGACTGGGGGCGCGCGCCGCG CTTCGACCAGACCACGCGGGACTGCCTCGCGCTCAACGAGCTCTGCCGCCCGCGCGACGACCCCGAGCTC CAGGACACCCTCTTTGGCGCGTACAAGGCGCCCGAGCTCTGCGACCGGCGCGGGCGCCCGCTCGAGGTGC ACGCGTGGGCGATGGACGCGCTCGTGGCCAAGCTGCTGCCGCTGCGCGTCTCCACCGTCGACCTGGGGCC CTCGCCGCGCGTCTGCGCCGCGGCCGTGGCGGCGCAGACGCGCGGCATGGAGGTGACGGAGTCCGCGTAC GGCGACCACATCCGGCAGTGCGTGTGCGCCTTCACGTCGGAGATGGGGGTGTGACCCTCGCCCCTCCCAC CCGCGCCGCGGCCAGATGGAGACCGCGACGGAGGCAACGACGACGGCGTGGGAGGGGGCTCGGGGCGCGT ATAAAGCTATGTGTATGTCATCCCAATAA
Protein Sequence	>gi\|51557518\|ref\|YP_068352.1\| thymidine kinase [Suid herpesvirus 1] MRILRIYLDGAYGTGKSTTARVMALGGALYVPEPMAYWRTLFDTDTVAGIYDAQTRKQNGSLSEEDAALV TAQHQAAFATPYLLLHTRLVPLFGPAVEGPPEMTVVFDRHPVAATVCFPLARFIVGDISAAAFVGLAATL PGEPPGGNLVVASLDPDEHLRRLRARARAGEHVDARLLTALRNVYAMLVNTSRYLSSGRRWRDDWGRAPR FDQTTRDCLALNELCRPRDDPELQDTLFGAYKAPELCDRRGRPLEVHAWAMDALVAKLLPLRVSTVDLGP SPRVCAAAVAAQTRGMEVTESAYGDHIRQCVCAFTSEMGV
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: a thymidine kinase PRV mutant is attenuated in pigs (Kimman et al., 1994). MUTATION: A UL23 mutant, in combination with mutations in glycoproteins G and E, is attenuated in raccoons (Weigel et al., 2003).
References	*Kimman et al., 1994:* Kimman TG, De Wind N, De Bruin T, de Visser Y, Voermans J. Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity. Virology. 1994; 205(2); 511-518. [PubMed: 7975253]. *Weigel et al., 2003:* Weigel RM, Hahn EC, Scherba G. Survival and immunization of raccoons after exposure to pseudorabies (Aujeszky's disease) virus gene-deleted vaccines. Veterinary microbiology. 2003; 92(1-2); 19-24. [PubMed: 12488067].


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UL23