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glycoprotein E

Victor ID 4994
Gene Name glycoprotein E
Sequence Strain (Species/Organism) Suid herpesvirus 1
NCBI Protein GI 307634504
Other Database IDs CDD:177575
CDD:190321
Taxonomy ID 10345
Gene Strand (Orientation) ?
Protein Name glycoprotein E
Protein Length 578
Protein Note envelope glycoprotein E; Provisional
Protein Sequence 
>gi|307634504|gb|ADN78283.1| glycoprotein E [Suid herpesvirus 1]
MRPFLLRAAQLLALLALALSTEAPSLSAETTPGPVTEVPSPSVEVWDDLSTEAGDDDLNGDLDGDDRRAG
FGSALASLREAPPAHLVNVSEGANFTLDARGDGAVLAGIWTFLPVRGCDAVSVTTACFETACHPDLVLGR
ACVPEAPEMGIGDYLPPEVPRLRREPPIVTPERWSPHLSVLRATPNDTGLYTLHDASGPRAVFFVAVGDR
PPAPADPVGPARHEPRFHALGFHSQLFSPGDTFDLMPRVVSDMGDSRENFTATLDWYYARAPPRCLLYYA
YEPCIYHPRAPECLRPVDPACSFTSPARARLVARRAYASCSPLLGDRWLTACPFDAFGEEVHTNATADES
GLYVLVMTHNGHVATWDYTLVATAAEYVTVIKELTAPARAPGTPWGPGGGDDPIYVDGVTTPAPPARPWN
PYGRTTPGRLFVLALGSFVMTCVVGGAVWLCVLCSRRRAASRPFRVPTRARTHMLSPVYTSLPTHEDYYD
GDDDDEEAGVIRRRPASPGGDSGYEGSYASLDPEDEFSSDEDNGLYVRPEEAPRSGFDVWFRDPEKPEVT
NGPNYGVTANRLLNARPA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gE mutant had strongly reduced virulence in pigs compared to wild-type PRV (Kimman et al., 1994).
MUTATION: A glycoprotein E mutant, in combination with UL23 and glycoprotein G mutations, is attenuated in raccoons (Weigel et al., 2003).
References
Kimman et al., 1994: Kimman TG, De Wind N, De Bruin T, de Visser Y, Voermans J. Inactivation of glycoprotein gE and thymidine kinase or the US3-encoded protein kinase synergistically decreases in vivo replication of pseudorabies virus and the induction of protective immunity. Virology. 1994; 205(2); 511-518. [PubMed: 7975253].
Weigel et al., 2003: Weigel RM, Hahn EC, Scherba G. Survival and immunization of raccoons after exposure to pseudorabies (Aujeszky's disease) virus gene-deleted vaccines. Veterinary microbiology. 2003; 92(1-2); 19-24. [PubMed: 12488067].