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IE180 (gp63)

Victor ID 4993
Gene Name IE180 (gp63)
Sequence Strain (Species/Organism) Suid herpesvirus 1
NCBI Gene ID 2952540
NCBI Protein GI 51557548
Locus Tag SuHV1_gp63
Genbank Accession BK001744
Protein Accession YP_068382
Taxonomy ID 10345
Gene Starting Position 102695
Gene Ending Position 107803
Gene Strand (Orientation) -
Protein Name transcriptional regulator ICP4
Protein pI 8.04
Protein Weight 141692.15
Protein Length 1446
DNA Sequence 
>gi|51557483:102695-107803 Suid herpesvirus 1, complete genome
CAGAAAATACAGCACAAACTTTATTTTCTCACTCTGAAAACAAACTCTTTTCTCACCCGATGGGAGAAGG
AGGAGAAGGGGACCGGGGGACCGCGGGAGGAGGAGAAGGGGACCGGGACGATCCTCCGCCGCCGAGCCCT
CCGCCGCGGCCGCCGCCGCCGCTTCCACCACCGCCGCCACCTCCGCCGCCGCCGCAGCCACCTCCGGCCG
GGGGATCCGCGCGGAGGAGAAGGAGAGGAGGAGGGCCACCGGGCCGGGGAGGCAGGCGCCGGGGAGGCAA
GCGCCGCCGGGCCGAGGGGACCGAGGCCGCCGCCGCGGACGCAGAGGAGGAGGAGGACGGGGACGGGGAC
GAGGACGAGGACGAGGACCGGGCCGAGGGCGAGGGGAGAGAAGACGGAGGAGAAGGGCCTCGAGGAGCCG
GTGGAGGGGCCGGAGAGTCAGAGTCAGAGTCCGGCCGGGCCGAGGGGGCGCCCCGCTCAGCGGAGCAGCA
GGTAGGGGTTGCCGGCGTCCTCGGCCTCCTCGTCGTCCGAGATGGCCTCCACCTTGATGGGCCCGAGCGG
GCCGCGGGGCCGGCCGTCGCCGCCGCGGACGCCGACGATCTCCACAGAGTCCCCGTCCTCGCCGGGGCCG
GCCCCGGCGCCCGAGGCCCCCGCGGGCCGGTGGGTCTCCACGGCGCCCCCGGCGGCGGCGCGGACGCTGG
TCTCGAAGGGGGCAAAGTCCCAGAGCACGGCCGGCGGGGCGCCCGCGGCGGCGACGGCGCCCGGGGTCAG
CACCAGCGGGGCGGCCTCGGCGTCGGGCTCCAGCAGCGCCGCGGCGCAGAAGGCGCGCAACTCGGCCGGC
AGGCCCTCGGGGCCGCGGAGCTCGGCGAGGCCCCGGCGGCCGCAGGAGACGAAGACGGGCCGCAGCGGGG
CGCCGAGCCCCCAGCGGTTGGCCGCGCGGTGCCCGAAGGCGGCGCCCGCGTCAAAGTCCGGGTCCCCGAG
CCCGAGCGCGGAGCGCTGGCGGGCCATGTCCTTGCAGCCGTCCACGGTGGGGAGCACGCGCTGGCGGTAG
GCGCGCGGCGGCAGCGGGACCGGGGTCCGGGGCCCGGCGCGGGTGCTCACCGTGTAGCGCACGTTGTCCT
GGCGGCAGAGGCGCAGCGGCTCGGCCCCGGGGTGCAGGCGGGCGAAGGAGGCCTCCACGCGGGCGAAGCA
GGCCGGGCCCACGATGGAGCTAGAGTCCAGCACGGCCGCGCGGAGCTCGCGGCACCCGGGCCAGCGCACG
GCGCACTGGGCGGCCGGGTCCAGGCGGACGCGGACGTAGACGTGGTAGTCCCCCACGGCCGGGCCGTCCG
CGGGCCAGTCCTCGATGGTGTCCAGCACGATGAGCCGGCGCCGCGCCGCGCCGAGCCGCGAGCAGAGGTA
CTCCACGGCGCCGGCGAAGCCGAGGTCCCGCGCCGAGAGCAGCAGCACCCCCTGGGCGTTGAGGCGGCCG
ATGTCGGGGCGCCCGGTCCAGTTCCCGGCCCAGGCGTGCGAGTCCGGCGTGCAGAGGCGGTGGGCGAAGG
CGGCGAGCAGCGCCGAGAGGCCGCCGCGGCGCGGGTCCCAGGCCGGGCGCGGGGCGCCCTCGGCGGGCTC
GGCGCAGAGCTCCTCGTGGGGCAGCGGGTCGTAGAGCACCACCACGCGCACGTCCTCGGGGTCGGCTATC
TGCCGCATCCAGGCGGCGCGGCGGCGGAGCGGGGCGCCGCGGCGCGCGGCGATGTGCGCCAGGGCGGCCG
GGTCGAAGGTGAGCGCCGGGCGCCAGAGTTCGGGGAAGACCTCCTGGTCCACGAGGGCGCGGGCCACCTC
GGGCGGGCAGTAGGCGGCGAGGGCCGCCTCGGAGGGCCGCGGCGTGTGGGTCTCGCCGGCCGGGACGCGG
CGGAAGCCGCCGTCGGGCGCGGGGTGCTCGGGCATGGGCCCGAGCGGGCGCCGGAGCCGGTCGTCCTCGG
AGGAGGAGGAGGAGGAGGACAGCAGCGCGGGAGCGGGGTCCGGAGCGGGCCCGAGTCCGAGGGAGCGGCG
CTTGCGCCGGGGCCCCCGGTCCTCTTCGTCGTCGCGGTGGCCGTGGCCGTCCCCGCGGAGGGCCGCGCCG
GAGAGCCCCTCGTCCTCCTCGCCGTCCCCGGGGCGGCGGGCCCCGGGCGCGCGGCGCTTCTTCTTGCGCC
GCTCGGGCGCTGGGTCCGGGCCGGCGGCGGGGGAGCTGGCGTAGCCGGAGGAGCCGGAGAGGCCGGACTT
GGTGCTGGAGCTGGACTTGGTGCTGGAGCTGGACTTGGTGCTGGCGGGGCTGGAGGGCCCGGAGCCGGGG
AGGCCGGAGGGGGCGCCCGCCGCCGCCGGCGCCGGCGCTGGGACGACGAGGCCGGGCTGCTCGGGCCAGA
GCGGGGGCAGGCCGGGCGCGGGCTCCGCGGGCCCGGGCCGCGCGGCGGCCTCGGCGAGCCGGGCCGCGGC
CACGTTGGCCGGGGCGAAGAGGGCCGCGGCGTAGGTCCAGGCGGCCTCGCGGGCGCGGGCCCCGTCCACG
CTGTAGCGCACCAGCGGCGCCACGGTGCGGGCGACGAGGGCGACAGAGTCCGCGGCCTGCCGCCGCTCGG
CCGGGCCGGCCCCGGGGATCGCGTCGCGGAGCGCGAGCAGCGCGGCCGTCACCTCCTCGAGGCAGGCGGG
CCCGAGGGCGGCCGGGGCGCGGGCGGGCGCGGGCAGCCGGAGCGGGCAGGGCAGCAGGCGCTCGAGGACG
CCGCGGCAGGCCAGGACGCAGGCGTCCGCCAGCTCGCGGGGCACGCGGCCGGGCTGCGCGGCGGCGAAGG
CGGCGCGGACGCGGGCGCAGAGGGCCTCGACGGTCGCCTCCCCGGCGCGGGGGTCCGCGGCGCGGCCCGG
GTAGGCCATGTCGGCGTAGGCCCGGCGGAGGCTCTGCAGGATGAAGGTCTTCTGGGTGCGATCGTAGCGG
CGGCTCATGGCCACGGCGCTCACCGCGTGCGGCAGGGCCCAGAGCGGGTCCTGGGCGGCCATGGCGTCCC
CGATGTGCGGCAGCGGCGGGGTCACGCTGCCGGTGATGAAGGAGCCGTGGCCGTGGGGCGCGTGGACCCG
GCGCTGGCAGAACTGGTTGAAGCGCTGGTCGGGGGCCTGCATCCGCGGGTTCTGCAGCCAGGACATGGCC
TCGCCGGCGGCCCCGCTGTAGATGAGGCGCACGAGGGCCTCGTGCTGCTTCCTCGAGTCCCCCATCTCCG
GGATGAAGACGGGCACGGGCCCGGCCGCGGCGCGGTAGCGGGCCGCGGCCTGGCGGACGTCGTCCTCGTC
CCAGAGCCCCTCGCGGGAGTCCCCGGCGCCGCCGTAGCGGACGCGGCCGTCGGCCGGAGGGTCGGAGCCG
GGCCAGGGCTCCCCGAGCGGGGTGAGCAGCGGCCCGTCGGTCGGCGGGGGCCCGTCGGCCATGAGCGAGA
GGTGGTTGTTGGTGGAGCGGCGCTTCCTGCGCGGGGGCCGGGCGGGCTCCGGGGCCGGGGCCGGGGAGGC
CGCGGCGGAGGAGGAGGCGGAGGAGGCCGAGGGCCGCGGGGCCGCGGCGGGCGCCGGCGGAGACGGTGGC
GGCCCGGCGCGGGCGAGTGGGGCGCCGGGCCGGACTCCTTCGTCTTCTTCTCCCTCGGAGGAGGACGAGG
ACGAGGAGGACGAGGAGGACGAGGAGGACGAGGACGAGGAGGAGGCCGAGCGCCGCGCGGCGGCGGCGGG
GGCCCGGGGGGCGGAGGGCGAGCGGGCCGGGGAGAGGTCCGAGTCGCTGCCGCTGCTGCTGGAGCTGCTG
AAGCCGCGGCCGCGGCGGAGGGCGCCCTCTCCGGCGCGGCGCCGGCGGGGCTGTCTCTGCGGGGGCGCCC
CGCCGTCCCCGGCGAGGCCGAGTCCGTCCTCGTCCTTCTCGGGGCCGCGGGCGACGGTCTCGACGGCGAC
GGTGGTGGTGGAGTTGGAGTTGGAGTTGGGGTTGGAGGAGACGGGGCTCCGGGCGCCAAGCGGCCGAGGA
TCGAGCCGCCTCGCGGCGGCGGGCTCGTCGAGCAGGGGCTCGCGGTGCTGGTGATGGTGACGACCGCGGT
CCCCTCCGGCGGAGGGGGCGCCGCCGCCGCCGGGCGCCGAGACCGGCCCGGCGGCGGGGGAGGCTGGGGA
AGCGGGCCCCCGCCGTGCCGGCGCTGCGGCCACCGCTGCTGGCTGTGCTGGTGGCGCCGGGGTCCGAGGC
CGCGCCGCCGGCCCGGGCTCACCGACCGGGTCCCCCCTCGCGGGGGACCATCTCCGCGGGGCTGCCGAGG
GGCCGGGAGAGCCGGAGGAGGAGGCCGGGGAGGCTGCGGAGGGGGACGAGCGCCCGGGGCCGCCGGGGGC
CCCGGCCTCTGCCGCTGCGAGTGCTGCCGGGGTCGGCGGCCGGGGCCCGGAGCCGGCCCGGGACCGGGGC
CCGAGGACGAGGTGACCGTGCTCGGAGCCCTGATGGAGAGCCCGACCGGGGGACCCGGCGGCCGGGGACC
CGGGCTCGTCCTCCTCCTCGTCTTCGTCGTCTAGCACCACGATCTCGCCCGAGCCCCGGCGGGGCTGCTG
CTGCTGCTGGGCCGAAGGAGGACGGGGCGGCCTCGTGGCTCCGGCCGCGGCCGCGAGGACGGCGGCCTCG
GCCTCGGCGGCGTCGTCGGAGAAGAGGCCGCCCGGGCCGAAGAGGAGATCCTCGCCGGAGGAGCCGCGGC
GCCGGGAGCCCTGGCTGCCGCCGTCGGGGCCGGACGCGATGCCCTCTTCCTCGGCCGCGGCGGCGGCCGC
CAGGAGCTGGCTGAAGTTGCCCTCGGTCTCGATGAAGTCAAAGAGATCGTCGGCCATGGTCTCGATCGGG
GTCTTTCTGCCTGAGCGAGGCCGGGCGCCGAGCGCGGAGAGCGGGCGGCGGAGAAGAAGGAGGAAGGCGG
CCGGAGGAGGAGAAGAAGAAGACTCTTCTCTGGCGGGCCGAGAGCCTCGGTGGGTCGGGCGTCCGTCGAG
GGCTGATAGCCGCCGGAGAGCCGGAGTCTTCAGAGTCCGCGCCGGAGCGGAGACGGTCGGATCCCCTCGG
GTTGGCAGAGAACGATGCTGTCCGTACCTGCACCGCAGTGAAGTGCTACGATGGAGACCGCGCTTATAA
Protein Sequence 
>gi|51557548|ref|YP_068382.1| transcriptional regulator ICP4 [Suid herpesvirus 1]
MADDLFDFIETEGNFSQLLAAAAAAEEEGIASGPDGGSQGSRRRGSSGEDLLFGPGGLFSDDAAEAEAAV
LAAAAGATRPPRPPSAQQQQQPRRGSGEIVVLDDEDEEEDEPGSPAAGSPGRALHQGSEHGHLVLGPRSR
AGSGPRPPTPAALAAAEAGAPGGPGRSSPSAASPASSSGSPGPSAAPRRWSPARGDPVGEPGPAARPRTP
APPAQPAAVAAAPARRGPASPASPAAGPVSAPGGGGAPSAGGDRGRHHHQHREPLLDEPAAARRLDPRPL
GARSPVSSNPNSNSNSTTTVAVETVARGPEKDEDGLGLAGDGGAPPQRQPRRRRAGEGALRRGRGFSSSS
SSGSDSDLSPARSPSAPRAPAAAARRSASSSSSSSSSSSSSSSSSSSEGEEDEGVRPGAPLARAGPPPSP
PAPAAAPRPSASSASSSAAASPAPAPEPARPPRRKRRSTNNHLSLMADGPPPTDGPLLTPLGEPWPGSDP
PADGRVRYGGAGDSREGLWDEDDVRQAAARYRAAAGPVPVFIPEMGDSRKQHEALVRLIYSGAAGEAMSW
LQNPRMQAPDQRFNQFCQRRVHAPHGHGSFITGSVTPPLPHIGDAMAAQDPLWALPHAVSAVAMSRRYDR
TQKTFILQSLRRAYADMAYPGRAADPRAGEATVEALCARVRAAFAAAQPGRVPRELADACVLACRGVLER
LLPCPLRLPAPARAPAALGPACLEEVTAALLALRDAIPGAGPAERRQAADSVALVARTVAPLVRYSVDGA
RAREAAWTYAAALFAPANVAAARLAEAAARPGPAEPAPGLPPLWPEQPGLVVPAPAPAAAGAPSGLPGSG
PSSPASTKSSSSTKSSSSTKSGLSGSSGYASSPAAGPDPAPERRKKKRRAPGARRPGDGEEDEGLSGAAL
RGDGHGHRDDEEDRGPRRKRRSLGLGPAPDPAPALLSSSSSSSEDDRLRRPLGPMPEHPAPDGGFRRVPA
GETHTPRPSEAALAAYCPPEVARALVDQEVFPELWRPALTFDPAALAHIAARRGAPLRRRAAWMRQIADP
EDVRVVVLYDPLPHEELCAEPAEGAPRPAWDPRRGGLSALLAAFAHRLCTPDSHAWAGNWTGRPDIGRLN
AQGVLLLSARDLGFAGAVEYLCSRLGAARRRLIVLDTIEDWPADGPAVGDYHVYVRVRLDPAAQCAVRWP
GCRELRAAVLDSSSIVGPACFARVEASFARLHPGAEPLRLCRQDNVRYTVSTRAGPRTPVPLPPRAYRQR
VLPTVDGCKDMARQRSALGLGDPDFDAGAAFGHRAANRWGLGAPLRPVFVSCGRRGLAELRGPEGLPAEL
RAFCAAALLEPDAEAAPLVLTPGAVAAAGAPPAVLWDFAPFETSVRAAAGGAVETHRPAGASGAGAGPGE
DGDSVEIVGVRGGDGRPRGPLGPIKVEAISDDEEAEDAGNPYLLLR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A gp50+gp63 deletion mutant in Pseudorabies virus was attenuated in pigs (Peeters et al., 1994).
References
Peeters et al., 1994: Peeters B, Bouma A, de Bruin T, Moormann R, Gielkens A, Kimman T. Non-transmissible pseudorabies virus gp50 mutants: a new generation of safe live vaccines. Vaccine. 1994; 12(4); 375-380. [PubMed: 8178562].