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purC/purD

Victor ID 4971
Gene Name purC/purD
Sequence Strain (Species/Organism) Francisella tularensis subsp. holarctica LVS
NCBI Gene ID 3952576
NCBI Protein GI 89255807
Locus Tag FTL_0396
Genbank Accession AM233362
Protein Accession YP_513169
Taxonomy ID 376619
Gene Starting Position 365666
Gene Ending Position 367978
Gene Strand (Orientation) ?
Protein Name fusion protein PurC/PurD
Protein pI 5.81
Protein Weight 82357.33
Protein Length 770
Protein Note 6.3.2.6
DNA Sequence 
>gi|89255449:365666-367978 Francisella tularensis subsp. holarctica LVS chromosome, complete genome
AATGTTTGATAAACAAATCATTGCTAATAATATAAAAAATGTTCTAAAATCAACAAATCTTGATATCAAG
AATAAATATATAGGTAAAGTAAGAGATATGTACTTTACTGATGACAAAAGTATTTTGATATCTACAGATA
GACAATCTGCTTTTGATAGATCTTTGGGTTTTATACCATTTAAGGGGCAAATCCTTGCACAATCATCAGT
ATGGTGGTTCAAAGAAACAGCACATATTGTCAAAAACCACTTTATAGACTCTCCAGATCCAAATGTTGTC
ATCGCGAGAAAGGCAAAAGTATTGCCAATTGAGTTTGTCGTTAGAGGTTATATAACTGGTTCAACTTCTA
CATCATTGTGGACACATTATAAAAACGGTAGCCGTGACTATTGTGGCAATATCCTGCCAGAAGGTTTAAA
AAAGAATCAAAAATTACCACAAAATATCCTTACACCAACTACCAAAGAGCAAGATCATGATCGCCCAATT
TCAGCTGAGGATATTGTCAAGGAAGGTTGGCTAACTCAGCAGCAGTGGGATTTTGCTTCACAAAAGGCTC
TAGAACTTTTTGAGTTTGGACAAAAAAAAGCCTTAGAACATGGCTTATTTTTGGCGGATACTAAATATGA
GTTTGGTATTGATGAGCAAACTGGAGAGATTATTTTGATCGATGAGATCCATACTCCAGATAGCTCAAGA
TTTTGGCTAAAAGATAGCTATGCTACAAGATTTGAAAATGGTGAAGAACCAGAGAATATTGATAAAGAAT
TTTTTAGATTATGGTTTGCAAAAAATTGTGACCCATATAATGATGAAGTTTTACCACAAGCACCACAAGA
GTTAGTTGTCGAATTATCTCAAAAATATATAACCCTTTTTGAAATGATAACAGGGCAAAAGTTTGAAGTA
CCAAGAGATTTAGAAAATATAAATCAACGTATTGTTAAAAATGTTACAGATTACTTAAATATGGAGAAGC
CAGTGAATATTCTTCTAGTAGGATCAGGAAGTAGAGAGCATGCGATAGCAGAAGCAGTCAAAAGAAGCTC
TATTGCAAATAAGCTTTTTTGTATAAGCACAGCGATTAACCCTGCGATAGATAAGATAACGCAAGGGTAT
CAAATCGCTGATATTTGTAATTGTGATGAAGTACTAGAGTATGCAAAATCACAAAGTATTGATATTGCGA
TTATCGGTCCTGAAGCACCACTTGAGGCTGGTCTAGCTGATGCACTTAAGACAGCAGCAATTGGCGTAGT
TGGTCCAACCAAAAAGTTAGCACAGCTTGAAACATCAAAAGGTTTCACTAGAGATCTGATCCGTGATTAT
GATATAGGCGCTAATCCTTTCTTTAGAAAGTTTAACTCGATGGATGGAGTCGAAGAGACTATCAAAAAAT
ATCAAAATCAATTTGTCATAAAAGCTGATGGTTTATGTGGTGGTAAAGGAGTGCTTGTTTGGGGCGATCA
TTTGCACAGCCTTGATGAGGCGATTAGACACTGTCAGTCATTGGTAGATGCTGGCAAAGAGTTTGTTATC
GAGGAGAAGCTTGTTGGCCAGGAGTTCTCGCTGATATCATTTACTGATGGCAAAAATTTTATCCATATGC
CAGCAGTCCAAGATCATAAGCGTGCCCATGAAGGTGACAAAGGTCCTAATACCGGTGGTATGGGTACTTA
TTCTGATGCTAATCATAGTTTACCGTTTTTATCAGCTGCTGATATCGAAAGAGCAAAACAAATAAATGAG
AAAGTTGTCAGAGCTTTAGCTGATAAATTTTGTGAACCATATCAAGGTATCCTTTATGGTGGCTTTATGG
CGACAAAAGATGATACTAAAGTGATCGAGTATAATGCACGTTTTGGTGATCCAGAAGCGATGAATCTACT
TACACTGTTAGAGACAGATTTTGTTGAGATTGCTCAAGCTATTACACAGGGTAAACTTGATACGGTCAAA
GCTAAGTTTAAAAATCAAGCAAGCGTATGTAAATATCTAGTACCGCTTGGCTATCCAAACCAATCAGTTA
AAAACTTTGAGATAGATATTTCACAATGCCCTGATAATGTCGAGCTTTTCTTAGGTGCTGTTGATTATAA
AGATGGTAAGCTAATTGGTACAGGTTCTAGAGCTATAGCTGTACTTGGTTTAGGTGATACAATAGCTGAA
GCAGAGCAAAAAGCCGAAAATGCTGTCAAAAATATTTATGGTAAACTATTTCATCGTCCAGATATTGGTA
CTAAAGAGCTTATCAATAAGCGTATCAAACACATGAATTTGTTGCGTGGTGATAAATATCAGGAGCTTAA
ATA
Protein Sequence 
>gi|89255807|ref|YP_513169.1| fusion protein PurC/PurD [Francisella tularensis subsp. holarctica LVS]
MFDKQIIANNIKNVLKSTNLDIKNKYIGKVRDMYFTDDKSILISTDRQSAFDRSLGFIPFKGQILAQSSV
WWFKETAHIVKNHFIDSPDPNVVIARKAKVLPIEFVVRGYITGSTSTSLWTHYKNGSRDYCGNILPEGLK
KNQKLPQNILTPTTKEQDHDRPISAEDIVKEGWLTQQQWDFASQKALELFEFGQKKALEHGLFLADTKYE
FGIDEQTGEIILIDEIHTPDSSRFWLKDSYATRFENGEEPENIDKEFFRLWFAKNCDPYNDEVLPQAPQE
LVVELSQKYITLFEMITGQKFEVPRDLENINQRIVKNVTDYLNMEKPVNILLVGSGSREHAIAEAVKRSS
IANKLFCISTAINPAIDKITQGYQIADICNCDEVLEYAKSQSIDIAIIGPEAPLEAGLADALKTAAIGVV
GPTKKLAQLETSKGFTRDLIRDYDIGANPFFRKFNSMDGVEETIKKYQNQFVIKADGLCGGKGVLVWGDH
LHSLDEAIRHCQSLVDAGKEFVIEEKLVGQEFSLISFTDGKNFIHMPAVQDHKRAHEGDKGPNTGGMGTY
SDANHSLPFLSAADIERAKQINEKVVRALADKFCEPYQGILYGGFMATKDDTKVIEYNARFGDPEAMNLL
TLLETDFVEIAQAITQGKLDTVKAKFKNQASVCKYLVPLGYPNQSVKNFEIDISQCPDNVELFLGAVDYK
DGKLIGTGSRAIAVLGLGDTIAEAEQKAENAVKNIYGKLFHRPDIGTKELINKRIKHMNLLRGDKYQELK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A purMCD mutant in Francisela tularensis was attenuated in mice (Pechous et al., 2006).
COG COG0151F, under F: Nucleotide transport and metabolism
References
Pechous et al., 2006: Pechous R, Celli J, Penoske R, Hayes SF, Frank DW, Zahrt TC. Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain. Infection and immunity. 2006; 74(8); 4452-4461. [PubMed: 16861631].