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FTL_0592

Victor ID 495
Gene Name FTL_0592
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3952786
NCBI Protein GI 89255990
Locus Tag FTL_0592
Protein Accession YP_513352.1
Taxonomy ID 119857
Gene Starting Position 578225
Gene Ending Position 579961
Gene Strand (Orientation) +
Protein Name dTDP-glucose 4,6-dehydratase
DNA Sequence 
>gi|89255449:578225-579961 Francisella tularensis subsp. holarctica LVS chromosome, complete genome
AATGTCTTTCTACGATAATAGAACGCTTAATTTCGTGGTAATAATAGTTTTAACTATTATTACTGTTAAT
TGGACTTTCTATATTTTCAAGCAAGATGTTAATTTACATTTTTTACTTGCATTAGTTTTGCTGAGATGCT
TGTCATCTTTTTTACTACTTAGAGATTATATGGCTAGTTGGCGTAAGTCGACTCAAAAAACTTTTTTACG
TAAGGCTTTTATTAATTTGCCAGTATTTTTCATAGTGGCATTATTTTTTTATGGCAAAGTCACTTTTTCG
TTGATATTCTCTGAGTTTTTATTTTATGTTTTTTTGATCAGTTTAAGTGTCTACTTTTATTGGTATTTGA
TGAACAGAGGATCAGTGGATAAAAGTAAAACTGCGGTTATTTATGGTGCAGGTGCTGCAGGAACAAAGAT
TGCTCAAGAACTTGCTTCTGCTGGTTATCGCATCAAATGTTTTGTTGATGACAATGAAACTTTACAAAAA
AGAAGTATTGATAGTAAAAAGGTTCTATCTAAAGCTGAATTAACAAAACTATTGCTATCTAGTAGATTTG
ACCTTTTGGTTATTGCATTGCCAAGAAATGCAAACCAAGTAGTCAAAAATATATATAAAGAATTTGAAAA
GGATTTTAATCAGATTAGAATTATGCCGCCTCTTGAGGAAATTCTTCAAGATGAGAATTTTATGTCACAG
TTGAAGCCTGTTTCACTCTATGATCTATTAGCGCGTGATACTAAGAGTTTAGATAAAGAATCTATCTCTA
ATTTTATCAAAAATAAGGTAGTGCTAGTCACAGGAGCTGGAGGTAGTATAGGTTCTGAAATAGTACATCA
ATGTATCAAGTATCAGGCAAAAGAGTTGATATTGGTTGATCATAGTGAGTTTAACTTATATAAAATTACT
GAGGAGTGTAGTCATTTTAATATCAATAGTGTGCTATGTTCTGTTTGTGATAGAAAAGCATTGGCTGAGG
TTTTTCAAAAGTATACTCCAAATATAGTATTTCATGCTGCTGCCTACAAGCATGTTCCCTTAGTTGAGGA
GAATATCTCTAGAGCAATTAGAAATAATATCTTAGGTACTAAGAATGCTATAGATCTGGCTATAGAAGCT
GGTGTTGAGTCATTTATATTGATTTCCACTGATAAAGCAGTGCGACCAACGAATGTTATGGGGGCTACCA
AGAGAGTTTGTGAGCTGTATTTACAGAATGTTGATCCCAAAAATACCAAGCTTGCTGCAGTGCGTTTTGG
TAATGTGCTTGGTAGTAGTGGCAGTGTGATTCCAAAATTTGAAGAGCAAATAAGAAATGGTGGTCCTGTT
ACAGTTACTCATCCTGAAATTACACGTTATTTTATGTTGATACCAGAAGCTTGTGAACTGGTCCTACAAG
CTGGTGCTATTGCAAAAAATTCAGAGGTCTTTGTCTTAGATATGGGGCAACCTGTCAAGATTATTGATCT
TGCTAAACAATTTATTAGACTTTCTGGTAGAGGTGATATTGATATTAAAATAGTTGGTTTGCGTCCAGGA
GAGAAACTTTACGAAGAGCTTTTGATAGAGGAAGATGATGTTAGTACCGACTATAAAGATATTTTTATTG
GTAGAAGGACTTTTTACGATATTAATACTCTAAACCAAGATATTGAATCGTTGATCAAGGATGATGTTGA
TCAGCTTGTGATATTAAAGAAAATTGTTCCGGAATTTGAACATAGATTGAATGGGTA
Protein Sequence 
>gi|89255990|ref|YP_513352.1| dTDP-glucose 4,6-dehydratase [Francisella tularensis subsp. holarctica LVS] MSFYDNRTLNFVVIIVLTIITVNWTFYIFKQDVNLHFLLALVLLRCLSSFLLLRDYMASWRKSTQKTFLRKAFINLPVFFIVALFFYGKVTFSLIFSEFLFYVFLISLSVYFYWYLMNRGSVDKSKTAVIYGAGAAGTKIAQELASAGYRIKCFVDDNETLQKRSIDSKKVLSKAELTKLLLSSRFDLLVIALPRNANQVVKNIYKEFEKDFNQIRIMPPLEEILQDENFMSQLKPVSLYDLLARDTKSLDKESISNFIKNKVVLVTGAGGSIGSEIVHQCIKYQAKELILVDHSEFNLYKITEECSHFNINSVLCSVCDRKALAEVFQKYTPNIVFHAAAYKHVPLVEENISRAIRNNILGTKNAIDLAIEAGVESFILISTDKAVRPTNVMGATKRVCELYLQNVDPKNTKLAAVRFGNVLGSSGSVIPKFEEQIRNGGPVTVTHPEITRYFMLIPEACELVLQAGAIAKNSEVFVLDMGQPVKIIDLAKQFIRLSGRGDIDIKIVGLRPGEKLYEELLIEEDDVSTDYKDIFIGRRTFYDINTLNQDIESLIKDDVDQLVILKKIVPEFEHRLNG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a FTL_0592 mutant was attenuated for infection in a mouse lung (Su et al., 2007)
COG COG1086MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism
References
Su et al., 2007: Su J, Yang J, Zhao D, Kawula TH, Banas JA, Zhang JR. Genome-wide identification of Francisella tularensis virulence determinants. Infection and immunity. 2007; 75(6); 3089-3101. [PubMed: 17420240].