Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

cyaA

Victor ID 4947
Gene Name cyaA
Sequence Strain (Species/Organism) Bordetella bronchiseptica RB50
NCBI Gene ID 2661688
NCBI Protein GI 33599313
Locus Tag BB0324
Genbank Accession BX640437
Protein Accession NP_886873
Taxonomy ID 257310
Gene Starting Position 331399
Gene Ending Position 336621
Gene Strand (Orientation) +
Protein Name bifunctional hemolysin-adenylate cyclase precursor
Protein pI 4.4
Protein Weight 167791.35
Protein Length 1740
Protein Note Also known as cyaortholog of Bordetella pertussis (BX470248) BP0760
DNA Sequence 
>gi|33598993:331399-336621 Bordetella bronchiseptica RB50, complete genome
CGTGCTGGATGTTTGGTTCTTGCAGAAGGATGAGGTTCTGAGCGCTACACACCGGTTGCGTCGGTGCGAA
TCCGTTCAATCGACTACTTATCGACAGATCCACATGCAGCAATCGCATCAGGCTGGTTACGCAAACGCCG
CCGACCGGGAGTCTGGCATCCCCGCAGCCGTACTCGATGGCATCAAGGCCGTGGCGAAGGAAAAAAACGC
CACATTGATGTTCCGCCTGGTCAACCCCCATTCCACCAGCCTGATTGCCGAAGGGGTGGCCACCAAAGGA
TTGGGCGTGCACGCCAAGTCGTCCGATTGGGGGTTGCAGGCGGGCTACATTCCCGTCAACCCGAATCTTT
CCAAACTGTTCGGCCGTGCGCCCGAGGTGATCGCGCGGGCCGACAACGACGTCAACAGCAGCCTGGCGCA
TGGCCATACCGCGGTCGACCTGACGCTGTCGAAAGAGCGGCTTGACTATCTGCGGCAAGCGGGCCTGGTC
ACCGGCATGGCCGATGGCGTGGTCGCGAGCAACCACGCAGGCTACGAGCAGTTCGAGTTTCGCGTGAAGG
AAACCTCGGACGGGCGCTATGCCGTGCAGTATCGCCGCAAGGGCGGCGACGATTTCGAGGCGGTCAAGGT
GATCGGCAATGCCGCCGGTATTCCACTGACGGCGGATATCGACATGTTCGCCATCATGCCGCATCTGTCC
AACTTCCGCGACTCGGCGCGCAGTTCGGTGACCAGCGGCGATTCGGTGACCGATTACCTGGCGCGCACGC
GGCGGGCCGCCAGCGAGGCCACGGGCGGCCTGGATCGCGAACGCATCGACTTGTTGTGGAAAATCGCTCG
CGCCGGCGCCCGTTCCGCAGTGGGCACCGAGGCGCGTCGCCAGTTCCGCTACGACGGCGACATGAATATC
GGCGTGATCACCGATTTCGAGCTGGAAGTGCGCAATGCGCTGAACAGGCGGGCGCACGCCGTCGGCGCGC
AGGACGTGGTCCAGCATGGCACTGAGCAGAACAATCCTTTCCCGGAGGCAGATGAGAAGATTTTCGTCGT
ATCGGCCACCGGTGAAAGCCAGATGCTCACGCGCGGGCAACTGAAGGAATACATTGGCCAGCAGCGCGGC
GAGGGCTATGTCTTCTACGAGAACCGTGCGTACGGCGTGGCGGGGAAAAGCCTGTTCGACGATGGGCTGG
GAGCCGCGCCCGGCGTGCCGGGCGGACGTTCGAAGTCCTCGCCGGATGTACTGGAAACGGTGCCGGCGTC
ACCCGGATTGCGGCGGCCGTCGCTGGGCGCAGTGGAACGCCAGGATTCCGGCTATGACAGCCTTGATGGG
GTGGGATCGCGATCGTTCTCGTTGGGCGAGGTGTCCGACATGGCCGCCGTGGAAGCGGCGGAACTGGAAA
TGACCCGGCAAGTCTTGCACGCCGGGGCGCGGCAGGACGATGCCGAGCCGGGCGTGAGCGGTGCGTCGGC
GCACTGGGGGCAGCGGGCGCTGCAGGGCGCCCAGGCGGTGGCGGCGGCGCAGCGGCTGGTTCATGCCATT
GCCCTGATGACGCAATTCGGCCGGGCCGGTTCCACCAACACGCCGCAGGAAGCGGCCTCGTTGTCGGCGG
CCGTGTTCGGCTTGGGCGAGGCCAGCAGCGCCGTGGCCGAAACCGTGAGCGGTTTTTTCCGCGGGTCTTC
GCGCTGGGCCGGCGGTTTCGGCGTGGCTGGCGGCGCGATGGCGCTGGGAGGCGGCATCGCCGCGGCCGTT
GGCGCCGGGATGTCGTTGACCGATGACGCGCCGGCCGGACAGAAGGCCGCCGCCGGCGCCGAGATCGCGC
TGCAGTTGACAGGTGGAACGGTCGAGCTGGCTTCTTCCATCGCGTTGGCGCTGGCCGCGGCGCGCGGCGT
GACCAGCGGCTTGCAGGTGGCGGGGGCGTCGGCCGGGGCGGCTGCCGGCGCATTGGCCGCGGCGCTCAGT
CCCATGGAGATCTACGGCCTGGTGCAGCAATCGCACTATGCGGATCAGCTGGACAAGCTGGCGCAGGAAT
CGAGCGCATACGGTTACGAGGGCGACGCCTTGCTGGCCCAGCTGTATCGCGACAAGACGGCCGCCGAGGG
CGCCGTCGCCGGCGTCTCCGCCGTCCTGAGCACGGTGGGGGCTGCGGTGTCGATCGCCGCGGCGGCCAGC
GTGGTAGGCGCCCCGGTGGCGGTGGTCACTTCCTTGTTGACCGGGGCTCTCAACGGCATCCTGCGCGGCG
TGCAGCAGCCCATCATCGAAAAGCTGGCCAATGATTACGCTCGCAAGATCGACGAGCTGGGCGGGCCGCA
AGCGTACTTCGAGAAAAACCTGCAGGCGCGTCACGAACAACTGGCCAATTCGGACGGCCTACGGAAAATG
CTGGCCGACCTGCAGGCCGGGTGGAACGCCAGCAGCGTGATCGGGGTGCAGACGACAGAGATTTCCAAGT
CGGCGCTCGAACTGGCCGCCATTACCGGCAACGCGGACAACCTGAAATCCGCCGACGTGTTCGTGGACCG
CTTCATCCAGGGCGAGCGGGTGGCCGGCCAGCCGGTGGTACTCGACGTCGCCGCCGGCGGCATCGATATC
GCCAGCCGCAAGGGCGAGCGGCCGGCGCTGACGTTCATCACGCCGCTGGCCGCGCCAGGAGAAGAGCAGC
GCCGGCGCACGAAAACGGGCAAGAGCGAATTCACCACATTCGTCGAGATCGTGGGCAAGCAGGACCGCTG
GCGCATCCGGGACGGCGCGGCCGACACCACCATCGATCTGGCCAAGGTGGTGTCGCAACTGGTCGACGCC
AATGGCGTGCTCAAGCACAGCATCAAACTGGAGGTGATCGGCGGAGATGGCGATGATGTCGTGCTTGCCA
ATGCTTCGCGCATCCATTACGACGGCGGCGCGGGAACCAACACGGTCAGCTATGCCGCCCTGGGCCGACA
GGATTCCATTACCGTGTCCGCCGACGGGGAACGTTTCAACGTGCGCAAGCAGTTGAACAACGCCAACGTG
TATCGCGAAGGCGTGGCTACCCAGAAAACCGCCTACGGCAAGCGCACGGAGAATGTCCAATACCGCCATG
TCGAGCTGGCCCGTGTCGGGCAACTGGTGGAGGTCGACACGCTCGAGCATGTGCAGCACATCATCGGCGG
GGCCGGCAACGATTCGATCACCGGCAATGCGCACGACAACTTCCTGGCCGGCGGGGCGGGCGACGACAGG
CTGGATGGCGGCGCCGGCAACGACACACTGGTCGGCGGCGAGGGCCACAACACGGTCGTCGGCGGCGCTG
GCGACGACGTATTCCTGCAGGACCTGGGGGTATGGAGCAACCAGCTCGATGGCGGCGCGGGCGTCGATAC
CGTGAAGTACAACGTGCACCAGCCTTCCGAGGAACGCCTCGAACGCATGGGCGACACGGGCATCCATGCC
GATCTTCAAAAGGGCACGGTCGAGAAGTGGCCGGCCCTGAACCTGTTCAGCGTCGACCATGTCAAGAATA
TCGAGAATCTGCACGGCTCCAGCCTGAACGACAGCATCGCCGGCGACGACCGGGACAACGAGCTCTGGGG
CGACGATGGCAACGACACGATACACGGCCGGGGCGGCGACGATATCCTGCGCGGCGGCCTGGGCCTGGAC
ACGCTGTATGGCGAGGACGGCAACGACATCTTCCTGCAGGACGACGAGACCGTCAGCGATGACATCGACG
GTGGCGCGGGACTGGACACCGTCGACTATTCCGCCATGATCCATGCAGGCAAGATCGTTGCGCCGCATGA
ATACGGCTTCGGGATCGAGGCGGACCTGTCCGAAGGGTGGGTGCGCAAGGCGGCCCGGCGCGGCATGGAC
TACTACGACAGTGTCCGCAGTGTCGAAAACGTCATCGGCACGAGCATGAAGGATGTGCTCATCGGCGACG
CGCAAGCCAATACCCTGATGGGCCAGGGCGGCGACGATACCGTGCGCGGCGGCGACGGCGATGATCTGCT
GTTCGGCGGCGACGGCAACGACATGCTGTATGGAGACGCCGGCAACGACACCCTCTACGGAGGGCTGGGC
GACGATACCCTTGAAGGCGGCGCGGGCAACGATTGGTTCGGCCAGACGCCGGCGCGCGAGCATGACGTGC
TGCGCGGCGGGGCTGGGGTGGATACCGTGGATTACAGCCAGGCGGGCGCGCATGCCGGCGTTGCCACGGG
TCGCATCGGGCTGGGTATTCTGGCGGACCTGGGCGCCGGCCGCGTCGACAAGCTGGGCGAGGCCGGCAGC
AGCGCCTACGATACGGTTTCCGGCATCGAAAATGTGGTGGGCACGGAACTGGCCGACCGCATCACGGGCG
ATGCGCAGGCCAACGTACTGCGCGGCGCGGGTGGCGCCGACGTGCTTGCGGGCGGCGAGGGCGACGATGT
GCTGCTGGGCGGCGACGGCGACGACCAGCTGTCGGGCGACGCCGGACGCGACCGCTTGTACGGCGAAGCC
GGTGACGACTGGTTCTTCCAGGATGCCGCCAATGCCGGCAATCTGCTCGACGGTGGTGACGGCAACGATA
CCGTGGATTTCAGCGGCCCGGGCCGGGGCCTCGACGCCGGCGCAAAGGGCGTATTCCTGAGCCTGGGCAA
GGGGTTCGCCAGCCTGATGGACGAACCCGAAACCAGCAACGTGTTGCGCCATATCGAGAACGCCGTGGGC
AGCGTGCGTGATGACGTGCTGATCGGCGACGCAGGCGCCAACGTCCTCAATGGCCTGGCGGGCAACGACG
TGCTGTCCGGCGGCGCCGGCGACGATGTGCTGCTGGGCGACGAGGGCTCGGACCTGCTCAGCGGCGATGC
GGGCAACGACGATCTGTTCGGCGGGCAGGGCGATGATACCTATCTGTTCGGGGCCGGGTACGGACATGAC
ACGATCTACGAATCGGGCGGCGGCCATGACACCATCCGTATCAACGCGGGGGCGGACCAGCTGTGGTTTG
CGCGCCAGGGCAACGACCTGGAGATCCGCATTCTTGGCACCGACGATGCACTTACCGTGCACGACTGGTA
TCGCGACGCCGATCACCGGGTGGAAGCCATCCATGCCGCCAACCAGGCCATAGACCCGGCCGGCATCGAA
AAGCTGGTCGAGGCAATGGCGCAGTACCCGGACCCCGGCGCGGCGGCGGCTGCCCCGCCGGCGGCGCGCG
TGCCGGACACGCTGATGCAGTCCCTGGCTGTCAACTGGCGCTG
Protein Sequence 
>gi|33599313|ref|NP_886873.1| bifunctional hemolysin-adenylate cyclase precursor [Bordetella bronchiseptica RB50]
MLDVWFLQKDEVLSATHRLRRCESVQSTTYRQIHMQQSHQAGYANAADRESGIPAAVLDGIKAVAKEKNA
TLMFRLVNPHSTSLIAEGVATKGLGVHAKSSDWGLQAGYIPVNPNLSKLFGRAPEVIARADNDVNSSLAH
GHTAVDLTLSKERLDYLRQAGLVTGMADGVVASNHAGYEQFEFRVKETSDGRYAVQYRRKGGDDFEAVKV
IGNAAGIPLTADIDMFAIMPHLSNFRDSARSSVTSGDSVTDYLARTRRAASEATGGLDRERIDLLWKIAR
AGARSAVGTEARRQFRYDGDMNIGVITDFELEVRNALNRRAHAVGAQDVVQHGTEQNNPFPEADEKIFVV
SATGESQMLTRGQLKEYIGQQRGEGYVFYENRAYGVAGKSLFDDGLGAAPGVPGGRSKSSPDVLETVPAS
PGLRRPSLGAVERQDSGYDSLDGVGSRSFSLGEVSDMAAVEAAELEMTRQVLHAGARQDDAEPGVSGASA
HWGQRALQGAQAVAAAQRLVHAIALMTQFGRAGSTNTPQEAASLSAAVFGLGEASSAVAETVSGFFRGSS
RWAGGFGVAGGAMALGGGIAAAVGAGMSLTDDAPAGQKAAAGAEIALQLTGGTVELASSIALALAAARGV
TSGLQVAGASAGAAAGALAAALSPMEIYGLVQQSHYADQLDKLAQESSAYGYEGDALLAQLYRDKTAAEG
AVAGVSAVLSTVGAAVSIAAAASVVGAPVAVVTSLLTGALNGILRGVQQPIIEKLANDYARKIDELGGPQ
AYFEKNLQARHEQLANSDGLRKMLADLQAGWNASSVIGVQTTEISKSALELAAITGNADNLKSADVFVDR
FIQGERVAGQPVVLDVAAGGIDIASRKGERPALTFITPLAAPGEEQRRRTKTGKSEFTTFVEIVGKQDRW
RIRDGAADTTIDLAKVVSQLVDANGVLKHSIKLEVIGGDGDDVVLANASRIHYDGGAGTNTVSYAALGRQ
DSITVSADGERFNVRKQLNNANVYREGVATQKTAYGKRTENVQYRHVELARVGQLVEVDTLEHVQHIIGG
AGNDSITGNAHDNFLAGGAGDDRLDGGAGNDTLVGGEGHNTVVGGAGDDVFLQDLGVWSNQLDGGAGVDT
VKYNVHQPSEERLERMGDTGIHADLQKGTVEKWPALNLFSVDHVKNIENLHGSSLNDSIAGDDRDNELWG
DDGNDTIHGRGGDDILRGGLGLDTLYGEDGNDIFLQDDETVSDDIDGGAGLDTVDYSAMIHAGKIVAPHE
YGFGIEADLSEGWVRKAARRGMDYYDSVRSVENVIGTSMKDVLIGDAQANTLMGQGGDDTVRGGDGDDLL
FGGDGNDMLYGDAGNDTLYGGLGDDTLEGGAGNDWFGQTPAREHDVLRGGAGVDTVDYSQAGAHAGVATG
RIGLGILADLGAGRVDKLGEAGSSAYDTVSGIENVVGTELADRITGDAQANVLRGAGGADVLAGGEGDDV
LLGGDGDDQLSGDAGRDRLYGEAGDDWFFQDAANAGNLLDGGDGNDTVDFSGPGRGLDAGAKGVFLSLGK
GFASLMDEPETSNVLRHIENAVGSVRDDVLIGDAGANVLNGLAGNDVLSGGAGDDVLLGDEGSDLLSGDA
GNDDLFGGQGDDTYLFGAGYGHDTIYESGGGHDTIRINAGADQLWFARQGNDLEIRILGTDDALTVHDWY
RDADHRVEAIHAANQAIDPAGIEKLVEAMAQYPDPGAAAAAPPAARVPDTLMQSLAVNWR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A double mutant strain of Bordetella Bronchiseptica lacking adenylate cyclase(cyaA gene) and type III secretion(bscN gene) is attenuated in mice (Mann et al., 2007).
References
Mann et al., 2007: Mann P, Goebel E, Barbarich J, Pilione M, Kennett M, Harvill E. Use of a genetically defined double mutant strain of Bordetella bronchiseptica lacking adenylate cyclase and type III secretion as a live vaccine. Infection and immunity. 2007; 75(7); 3665-3672. [PubMed: 17452472].