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hemA

Victor ID 4937
Gene Name hemA
Sequence Strain (Species/Organism) Vibrio cholerae Bengal
NCBI Protein GI 12656010
Other Database IDs CDD:178819
CDD:133452
CDD:144372
Taxonomy ID 666
Gene Strand (Orientation) ?
Protein Name glutamyl-tRNA reductase
Protein Length 419
Protein Note glutamyl-tRNA reductase; Reviewed; PRK00045
Protein Sequence 
>gi|12656010|gb|AAK00701.1|AF227752_2 glutamyl-tRNA reductase [Vibrio cholerae]
MSLLAIGINHNTASVELREKVAFGPEKLSLALNQLSTSSHVKGGVILSTCNRTEIYCDVRSASKNKVIEW
LSQFHQVSLDELKPSLYVHEEQAAIRHLMRVACGLDSLVLGEPQILGQVKQAYAEARENHAVNPATEKLF
QKAFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESLADATVLLVGAGETIELVAKHLAGHHCKRMIVA
NRTRERALSLAQQFGADVIALNEIPDYLAQADIVISSTASPLPIIGKGMVESALKARRHQPMLLVDIAVP
RDIEPQVGKLNDAYLYSVDDLQSIVDSNIEQRKVEAIQAEAIVSEESATFMSWMRSLQAVDSIRDYRKQA
NEAREELLNKSLQALAAGGDPEKLLIELSNKLTNKLIHTPTRALQTAAEQGEPAKLAVIRQSLGLDDLN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A hemA mutant is highly attenuated in mice and rabbits (Ravichandran et al., 2006).
References
Ravichandran et al., 2006: Ravichandran M, Ali SA, Rashid NH, Kurunathan S, Yean CY, Ting LC, Bakar AS, Lalitha P, Zainuddin ZF. Construction and evaluation of a O139 Vibrio cholerae vaccine candidate based on a hemA gene mutation. Vaccine. 2006; 24(18); 3750-3761. [PubMed: 16102875].