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guaB

Victor ID 4912
Gene Name guaB
Sequence Strain (Species/Organism) Francisella tularensis subsp. holarctica FTNF002-00
NCBI Gene ID 5523917
NCBI Protein GI 156502929
Locus Tag FTA_1563
Genbank Accession CP000803
Protein Accession YP_001428994
Taxonomy ID 458234
Gene Starting Position 1398915
Gene Ending Position 1400375
Gene Strand (Orientation) -
Protein Name inosine-5'-monophosphate dehydrogenase
Protein pI 7.79
Protein Weight 47330.3
Protein Length 486
Protein Note 1.1.1.205
DNA Sequence 
>gi|156501369:1398915-1400375 Francisella tularensis subsp. holarctica FTNF002-00 chromosome, complete genome
TTTAAGACTGGTAATTAGGTGGTTCTTTAGTAATCGTGACGTTATGTACATGCGATTCATTAAATCCAGC
ACCTGTAATTTGTACAAATGTCGGTTCTGTTCGCATTGTTTGGATATCTTTTGAGCCAGTATAGCCCATA
CTAGATTTCAGACCACCTATTAGCTGATGAATCACTGCAGATAATAAACCTTTGTATGGTACTCTGCCTT
CAACGCCTTCTGGAACAAACTTTTTCGCCTCTGTTTCACTTTGGAAATATCTATCAGATGAGCCTTTCTC
CATAGCACCAAGAGAACCCATACCACGATATGATTTATAAGAGCGACCTTGGAAAAGCTCAACCTCCCCT
GGTGATTCTTCAGTACCTGCAAAAAGCCCTCCAATCATAACTACAGATGCTCCAGCAACTATAGCTTTTG
CAATATCACCGGAATATCTAATACCGCCATCTGCAATCACAGGCACTCCAGTTCCTTTTAATGCCTCTGC
AACATTAGCTATCGCTGTAATTTGTGGTACACCAACACCAGCAACAATTCTGGTAGTACAGATTGAGCCA
GGTCCAATACCAACCTTGACAGCATCAGCACCAGCTTTAACTAGATCTTTAGCAGCTTCTGCTGTAGCGA
TATTACCACCTATAACCTGAATATGTGGATAGTTATCTTTAACCCACTTAACTGTATCTAACACACCTTG
TGAATGTCCATGAGCAGTATCTACAACAATAATATCGACTCCTTCAGCTGCCAATGCTGCAACACGCTCT
TTAGTATTAACAGCGGTTCCAACAGCAGCGCCAACTCTCAAACGCCCAAGAGAATCTTTACAAGCATTTG
GTTTATTTTGTGATCTTTCGATATCTTTTGTTGTAATAAGACCGACCAACTCGCCTTGTTCATTAACTAC
AAGCAACTTCTCAATTTTATGCTCATGAAGTTTCTTTTTAATCGCTCCTTGAGAAGCATCTTCAGGCACT
GTTACAAGTTTTTCTCTAGGTGTCATAATAGAGCTAACAGGTTCATCTAAATCTTTTGCAAATCTAAAAT
CACGCCTTGTAACAATACCTATGATTTTATTATTATCATCAACAACGGGAAAACCAGAGAAATTATGTTC
TTTAGCTAGTTGCATGATTTCTTTAATTGAGCTTTCTTGTTTAATGGTAATGGGATCAATCACCATTCCA
TTTTCAAATCTTTTTACCTTTTTAACTTCTTGGGCTTGGGCTTGAATAGACATATTCTTATGAATAATAC
CAATACCACCTTCCTGGGCTATCGCAATAGCTAGGCGTGACTCAGTAACCGTATCCATAGCTGCAGATAC
TAAAGGAATATTTAACTGAATATCTCTAGTTATATTTGTCTTCAAATCAACTTGATGAGGAAGAACATTT
GAATATCTAGGTGATAGCAATACATCATCAAAAGTGATTGCCTGCTGAGTAATTCTTAACA
Protein Sequence 
>gi|156502929|ref|YP_001428994.1| inosine-5'-monophosphate dehydrogenase [Francisella tularensis subsp. holarctica FTNF002-00]
MLRITQQAITFDDVLLSPRYSNVLPHQVDLKTNITRDIQLNIPLVSAAMDTVTESRLAIAIAQEGGIGII
HKNMSIQAQAQEVKKVKRFENGMVIDPITIKQESSIKEIMQLAKEHNFSGFPVVDDNNKIIGIVTRRDFR
FAKDLDEPVSSIMTPREKLVTVPEDASQGAIKKKLHEHKIEKLLVVNEQGELVGLITTKDIERSQNKPNA
CKDSLGRLRVGAAVGTAVNTKERVAALAAEGVDIIVVDTAHGHSQGVLDTVKWVKDNYPHIQVIGGNIAT
AEAAKDLVKAGADAVKVGIGPGSICTTRIVAGVGVPQITAIANVAEALKGTGVPVIADGGIRYSGDIAKA
IVAGASVVMIGGLFAGTEESPGEVELFQGRSYKSYRGMGSLGAMEKGSSDRYFQSETEAKKFVPEGVEGR
VPYKGLLSAVIHQLIGGLKSSMGYTGSKDIQTMRTEPTFVQITGAGFNESHVHNVTITKEPPNYQS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A guaB mutant is attenuated in mice (Santiago et al., 2009).
COG COG0516F, under F: Nucleotide transport and metabolism
References
Santiago et al., 2009: Santiago AE, Cole LE, Franco A, Vogel SN, Levine MM, Barry EM. Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes. Vaccine. 2009; 27(18); 2426-2436. [PubMed: 19368784].