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guaA

Victor ID 4911
Gene Name guaA
Sequence Strain (Species/Organism) Francisella tularensis subsp. holarctica LVS
NCBI Gene ID 3951701
NCBI Protein GI 89256406
Locus Tag FTL_1071
Genbank Accession AM233362
Protein Accession YP_513768
Taxonomy ID 376619
Gene Starting Position 1023478
Gene Ending Position 1025028
Gene Strand (Orientation) ?
Protein Name GMP synthase
Protein pI 6.04
Protein Weight 52837.22
Protein Length 516
Protein Note contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
DNA Sequence 
>gi|89255449:1023478-1025028 Francisella tularensis subsp. holarctica LVS chromosome, complete genome
AATGACAGATATACATAATCATAAGATTTTGATTTTAGATTTTGGCTCGCAATATACACAACTTATTGCT
CGTAGAGTAAGAGAAGTAGGTGTTTTTTGTGAAATTTTCCCTCATGATGTAGCAGCTGATTTTATCAAAA
ATTATCAAGCAAAAGGAATAATTTTATCAGGTGGTCCTGAGTCAGTTTATGATTCTGATGTCAAAGCTCC
TGAGATAGTTTTTGAGCTTGGAGTACCTGTTTTGGGTATTTGTTATGGCATGCAAACAATGGTAATGCAG
CATGGTGGCGAAGTAAAAGGAGCTGATCAAAGTGAATTTGGTAAGGCAATTATAAATATCCTAAATTTAA
CAAATAACATATTTTCAAATATGGAGCATGAGCAGCTAGTTTGGATGAGTCATAGTGACAAAGTCACTCA
AACTGGTGAGCATTTTGAGATAATTGCTTCTTCAACAAATGCTCCAGTTGCGGCAGTTGCACATAAAAAT
AAGCCTTTTTTTGGTGTGCAGTTTCACCCAGAAACTACTCATACAGAAAATGGTAAGCAAATTATTGAGA
ATTTTGTCGTTAATATCTGCGGATGTGATACTCTGTGGAATATCGAAAACATTATCGAAAATGATATAAA
AGAAATTAAACAAAAAGTTGGTACTGATAAAGTAATTTTAGGGCTATCTGGAGGTGTTGATTCATCTGTT
GTAGCTGCGATATTACATCAAGCTATCGGCGATCAGCTAACTTGTATATTTGTAGATACTGGTTTACTGC
GCCTTAATGAGGGTGATCAAGTTATGCAAGTATTTGCAGAGCATATGGATATTAATGTTATTCGTATCAA
TGCAAAAAATAGATTCTTAGATGCCCTAAGGGGTATCTGTGATCCAGAACAAAAACGTAAAATTATCGGT
AAGCTATTTGTTGATATTTTTGATGAAGAGGCTGCTAAGATAGAGAATGCTAAATGGCTTGCGCAGGGCA
CTATCTACAGTGATGTAATTGAATCAGCTAGCAATAATCAGTCTAAAGCACATGTAATTAAATCACATCA
TAATGTTGGTGGCTTACCAAAAGAAATGAAACTTAAGCTTTTAGAACCATTAAGAGAGCTTTTCAAAGAT
GAGGTTCGTAAATTAGGCTTAGGTTTAGGATTACCTTATAATATGCTTTATAGACATCCATTTCCTGGTC
CTGGTCTTGGAGTACGTATATTAGGTGAAATAAAGAAAGAGTATGTAGAAACGTTACAAAAAGCTGATGC
TATATTTACAGAAGAGCTTTATAAACATAATTTATACCATGATGTTTCTCAAGCTTTTGGGGTGTTTTTA
CCTATCAAATCGGTAGGTGTAGTTGGTGATCAGCGTAGATATGAGTATGTAATAGCTCTAAGAGCTGTCG
TTAGTATCGATTTTATGACTGCAACGTGGGCTAATTTACCTTATGATTTTCTGTCACTAGTTTCAAATAG
AATTGTAAATGAAGTAAAACAAGTATCAAGAGTTGTGTATGATGTGACAGGAAAACCACCTGGAACAATT
GAATGGGAATA
Protein Sequence 
>gi|89256406|ref|YP_513768.1| GMP synthase [Francisella tularensis subsp. holarctica LVS]
MTDIHNHKILILDFGSQYTQLIARRVREVGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAP
EIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNLTNNIFSNMEHEQLVWMSHSDKVTQ
TGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIK
EIKQKVGTDKVILGLSGGVDSSVVAAILHQAIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRIN
AKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESASNNQSKAHVIKSHH
NVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADA
IFTEELYKHNLYHDVSQAFGVFLPIKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLPYDFLSLVSNR
IVNEVKQVSRVVYDVTGKPPGTIEWE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A guaA mutant is highly attenuated in mice (Santiago et al., 2009).
COG COG0519F, under F: Nucleotide transport and metabolism
References
Santiago et al., 2009: Santiago AE, Cole LE, Franco A, Vogel SN, Levine MM, Barry EM. Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes. Vaccine. 2009; 27(18); 2426-2436. [PubMed: 19368784].