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lpd

Victor ID 4898
Gene Name lpd
Sequence Strain (Species/Organism) Mycoplasma gallisepticum str. R(low)
NCBI Gene ID 1089767
NCBI Protein GI 31544686
Locus Tag MGA_0161
Genbank Accession AE015450
Protein Accession NP_853264
Taxonomy ID 710127
Gene Starting Position 667939
Gene Ending Position 669342
Gene Strand (Orientation) -
Protein Name dihydrolipoamide dehydrogenase (E3) component of pyruvate dehydrogenase complex
Protein pI 7.54
Protein Weight 47042.25
Protein Length 467
Protein Note MGA_0161; Lpd [C] COG1249 Dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes; PRK06416, dihydrolipoamide dehydrogenase; MGRL526
DNA Sequence 
>gi|294660180:667939-669342 Mycoplasma gallisepticum str. R(low) chromosome, complete genome
TTTAGTGTTTTTTGTTGAAGTGGTTATAAATTGCTTGTTTAGCACATTCTGAGATGATTTCAGCAATTGT
TGGGTGTGGGTGAATTGCTTGTTCTAATTCGAACACTGTTAGTTCATTTTCCATTGCTAAAGCAATTTCA
GAGATCATATCACTAGCAGTAGAAGCAATCAAGACACATCCTAAGATCTCACCATACTTCTTACCGAACA
TGAATTTAATGAATCCTTCAGTTGAACCATCAGCAATCGCTTTACCATTAACTGCCATTGGCATCTTAGA
AACCACATATTCAATGTTCTTTTCTTTTAATTGTTGTTCAGTATAACCAATTGTTGCGATCTCTGGGTAA
GTATAAATACATCCAGGAGTGGTTAGTGAACTTAATTTCTTTGTCTTACGATTTAAGATCGTATCAACAG
CATATAATGCTTGGTGGTACGCATAATGAGCTAGCATGATCTGACCAGCAGCATCACCAATCACATAGAT
TGAATCAGTTGAAGTTTGTAACTTGTCGTTTAATTTAATGCGGTTGCGATCATCTCTTGCTACGTTGAAT
GATCCAAAAACTTGATCATTAACTACCCGACCAACTGATTCTAGGATATATTGAGAAGGTAGTTGGTAAG
CTGTGCCATTATCTTCATAGATAATTGCGTTGTTTTGGTAACCTAAAATCTTGGCATTATAAACAACATT
AACGCCTAATGATTTCATGCGTTTAGCAATGAAATCACTTGCATCTTGATCTAATAATTCGCATAAACGA
TCAACAGCTTGTAAGATCGTTACTTTAGTACCTAATGAAGCGTATAACATCGCAAATTCGATCCCAATTA
CACCCCCACCGATCACAACTAATGATTGAGGGATTTGTGGTAATTCAAGTGCTTTAGTTGACTCAATGAT
CACACCTTCAGCACGACCTTGGTCAAACCCTGGAAGTGGTAATTTTCTTGGTGAAGAACCAGTGGCAACG
ATAATATCTTTTGTTGTAATGTAAAATGTTTGGTTGTTTACAGTTACTGTATGACCATCAACAATTCTAG
CTTCACCTACGATCGTATCAGCTTTAGCTACTTTTAAGATCGTTTTTACCCCGTTAACTAGCTTATTAAC
AACAGCTTCTTTTCTTTTTAAGATATTTGCTCAGTTAACAGATAATTGATTATTAACTAAATCTAGTCCG
TATTCAGCTGCTTTTTCAATGTAGTGTTTAACTTTAGAAGATTGTAGTAATGTTTTAGTTGGAATACAAC
CAACATTTAAACAAACCCCACCATAAGTTCCACGTTCAATTACTAAAGTTTTAAGACCGTTTTTTGCAGC
ATGTTCACCAGCTACATAACCACCAGGTCCAGCACCGATAACAATTAGATCGTAATTATACATATTAAGT
ACCA
Protein Sequence 
>gi|31544686|ref|NP_853264.1| dihydrolipoamide dehydrogenase (E3) component of pyruvate dehydrogenase complex [Mycoplasma gallisepticum str. R(low)]
MVLNMYNYDLIVIGAGPGGYVAGEHAAKNGLKTLVIERGTYGGVCLNVGCIPTKTLLQSSKVKHYIEKAA
EYGLDLVNNQLSVNWANILKRKEAVVNKLVNGVKTILKVAKADTIVGEARIVDGHTVTVNNQTFYITTKD
IIVATGSSPRKLPLPGFDQGRAEGVIIESTKALELPQIPQSLVVIGGGVIGIEFAMLYASLGTKVTILQA
VDRLCELLDQDASDFIAKRMKSLGVNVVYNAKILGYQNNAIIYEDNGTAYQLPSQYILESVGRVVNDQVF
GSFNVARDDRNRIKLNDKLQTSTDSIYVIGDAAGQIMLAHYAYHQALYAVDTILNRKTKKLSSLTTPGCI
YTYPEIATIGYTEQQLKEKNIEYVVSKMPMAVNGKAIADGSTEGFIKFMFGKKYGEILGCVLIASTASDM
ISEIALAMENELTVFELEQAIHPHPTIAEIISECAKQAIYNHFNKKH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: An lpd mutant is highly attenuated in chickens (Gates et al., 2008).
COG COG1249C, under C: Energy production and conversion
References
Gates et al., 2008: Gates AE, Frasca S, Nyaoke A, Gorton TS, Silbart LK, Geary SJ. Comparative assessment of a metabolically attenuated Mycoplasma gallisepticum mutant as a live vaccine for the prevention of avian respiratory mycoplasmosis. Vaccine. 2008; 26(16); 2010-2019. [PubMed: 18342996].