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ORF-A

Victor ID 4895
Gene Name ORF-A
Sequence Strain (Species/Organism) Feline immunodeficiency virus
NCBI Gene ID 1724707
NCBI Protein GI 9626705
Locus Tag FIVgp4
Genbank Accession M25381
Protein Accession NP_040975
Taxonomy ID 11673
Gene Starting Position 5991
Gene Ending Position 6227
Gene Strand (Orientation) +
Protein Name hypothetical protein
Protein pI 9.29
Protein Weight 9252.28
Protein Length 78
DNA Sequence 
>gi|9626701:5991-6227 Feline immunodeficiency virus, complete genome
AATGGAAGACATAATAGTATTATTCAATAGGGTCACTGAGAAACTAGAAAAAGAATTAGCTATCAGAATA
TTTGTATTAGCACATCAATTAGAAAGGGACAAAGCTATTAGATTACTACAAGGATTATTTTGGAGATATA
GATTTAAGAAACCCCGAGTAGATTATTGTTTATGTTGGTGGTGTTGCAAATTCTATTATTGGCAGTTGCA
ATCTACATTATCAATAACTACTGCTTA
Protein Sequence 
>gi|9626705|ref|NP_040975.1| hypothetical protein FIVgp4 [Feline immunodeficiency virus]
MEDIIVLFNRVTEKLEKELAIRIFVLAHQLERDKAIRLLQGLFWRYRFKKPRVDYCLCWWCCKFYYWQLQ
STLSITTA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Feline immunodeficiency virus (FIV) made defective in the accessory gene ORF-A were previously shown to be greatly attenuated in its ability to replicate in lymphocytes but to grow normally or near normally in other cell types (Pistello et al., 2005).
References
Pistello et al., 2005: Pistello M, Bonci F, Isola P, Mazzetti P, Merico A, Zaccaro L, Matteucci D, Bendinelli M. Evaluation of feline immunodeficiency virus ORF-A mutants as candidate attenuated vaccine. Virology. 2005; 332(2); 676-690. [PubMed: 15680433].