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aroA

Victor ID 4892
Gene Name aroA
Sequence Strain (Species/Organism) Bordetella bronchiseptica RB50
NCBI Gene ID 2659145
NCBI Protein GI 33602442
Locus Tag BB3469
Genbank Accession BX640447
Protein Accession NP_890002
Taxonomy ID 257310
Gene Starting Position 3712371
Gene Ending Position 3713699
Gene Strand (Orientation) -
Protein Name 3-phosphoshikimate 1-carboxyvinyltransferase
Protein pI 5.16
Protein Weight 43401.08
Protein Length 442
Protein Note catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
DNA Sequence 
>gi|33598993:3712371-3713699 Bordetella bronchiseptica RB50, complete genome
TTCAGTCCCGCGCGGCCAGCAGGCCCGCGTACACGTCGAAATAATCGGGGAAAGTCTTGCTGACGCAGCC
CGGATCCAGGATGCGCACCGCAGCCGGACCGAACGCGGCCAGCGAGAAGCACATGGCCATGCGGTGGTCG
TCCCAGGTGCCGATGTGGGCGTCGCGCCAGCCGCCGGGCGCCGGCGGCGCCACCTCCAGCCAGTCCGCCC
CGCTTTGCACGCCCGCCCCCAGCTTCTCCAGCTCGGTGTGCATGGCGTGGATGCGGTCGGTCTCCTTGAC
GCGCCAGCTGCCGATGTTGCGCAGGCGGCATGGGCCGTCGGCGTACAGCGCCAGCGTCGCGGCCGTCATG
GCGGCGTCGGGAATCAGGTTGAAGTCGGCGTCGAACGCCTTCAGGCGTCCGCCCTCGGCCACCCGCACGC
CGCGCGTCTCGATCCAGCCCGGGCCATAGCGCACGTCGGCGCCCATCGCCGCCAGCGTCGCGGCGAACGC
CACGTCGCCCTGGATGCTGTCCTCGCCCACGCCGGTGACGCGCACCGGCCCGCCGCCGATGGCGCCCAGG
GCCAGGAAGTACGACGCCGTCGAGGCATCGCCCTCGATCGCCATGCGGCCCGGGCCGCGGTAGGCCGCAT
CGCGCGCGATCGTGAAGGCGCGCCAGCCGTCGCGCCGCACCGACACGCCAAAACGCGCCATCAGATTGAG
CGTGATCTCGATATAGGGTTTGGAAATCAGCTCGCCCACCACCTCGATGGTGATGTCCTGGCCGCTGCGC
CGAGCCAGCACGGGGGCGGCCATCAGCAAGGCGGTCAGGAACTGGCTGGACACCGAGCCCTCCACCCGCA
CCGGCCCGTCGACGCGAATGCTGCCGCCGCCGATGCGCAGCGGCGGATACCCCGCCTGCCCCAGATATTC
GATCCCGGCGCCGAACTGGCGCAAGGCGTCGACCAGGTCGCCGATGGGCCGCTCGTGCATGCGCGGCACG
CCGGACAGGCGGTAATCGCCGCCCATCAACGCCAGCGCCGCGGTCAGCGGCCGGAACGCGGTGCCGGCGT
TGCCCAGGAACAGCTCGGCCTGTTCGGTCGGAAAGCGCGCCACGCCTTCGATGGTCACGCAGCCATCGGC
CACCTCGCCCACCGATACGCCCAGCTGGCGCAACGCGGCCAGCATGACGCGGGTGTCATCGGAATCGAGC
AGGCCCGTGATTTCGGTGCTGCCTTCGGCCAGCGCGGCCAGCAGCAATACCCTGTTGGAGATGCTCTTGG
AACCCGGCAGGGCCACCTCGCCGCGCGCCAGGCGCGCCGCGGGCAGGTCGAGATATGCCAATCCGCTCA
Protein Sequence 
>gi|33602442|ref|NP_890002.1| 3-phosphoshikimate 1-carboxyvinyltransferase [Bordetella bronchiseptica RB50]
MSGLAYLDLPAARLARGEVALPGSKSISNRVLLLAALAEGSTEITGLLDSDDTRVMLAALRQLGVSVGEV
ADGCVTIEGVARFPTEQAELFLGNAGTAFRPLTAALALMGGDYRLSGVPRMHERPIGDLVDALRQFGAGI
EYLGQAGYPPLRIGGGSIRVDGPVRVEGSVSSQFLTALLMAAPVLARRSGQDITIEVVGELISKPYIEIT
LNLMARFGVSVRRDGWRAFTIARDAAYRGPGRMAIEGDASTASYFLALGAIGGGPVRVTGVGEDSIQGDV
AFAATLAAMGADVRYGPGWIETRGVRVAEGGRLKAFDADFNLIPDAAMTAATLALYADGPCRLRNIGSWR
VKETDRIHAMHTELEKLGAGVQSGADWLEVAPPAPGGWRDAHIGTWDDHRMAMCFSLAAFGPAAVRILDP
GCVSKTFPDYFDVYAGLLAARD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Inactivation of the aroA gene highly attenuates B. bronchiseptica, severely impairing its ability to colonize and survive in the respiratory tract of mice (Stevenson and Roberts, 2002).
References
Stevenson and Roberts, 2002: Stevenson A, Roberts M. Use of a rationally attenuated Bordetella bronchiseptica as a live mucosal vaccine and vector for heterologous antigens. Vaccine. 2002; 20(17-18); 2325-2335. [PubMed: 12009288].