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FTL_0525

Victor ID 489
Gene Name FTL_0525
Sequence Strain (Species/Organism) Francisella tularensis
NCBI Gene ID 3952665
NCBI Protein GI 89255932
Locus Tag FTL_0525
Protein Accession YP_513294.1
Taxonomy ID 119857
Gene Starting Position 505162
Gene Ending Position 506676
Gene Strand (Orientation) +
Protein Name fumerate hydratase
DNA Sequence 
>gi|89255449:505162-506676 Francisella tularensis subsp. holarctica LVS chromosome, complete genome
AATGGCTGTTATCAAAGCAGAAGATCTAGTAAATAGTGTTGCAGAAGCATTGCAATATATATCTTATTAT
CATCCAAAAGATTTTATTGATGCAATGTATGAAGCATATCAGCGTGAAGAGTCAAAACCAGCTAAAGATG
CAATGGTGCAAATTCTAATAAACTCGAGAATGTCTGCTATTGGTAAGCGTCCGATTTGCCAAGATACAGG
GATGGTATGCGCTTTTGTCAAAGTTGGTATGGATGCAAAACTTGACAAGACTGATAGAACAATTACAGAA
CTTATTAATGAGGGTGTGCGTCGTGGCTATAATGATCCGTATAACCCTTTGAGAGCATCTATGGTTTTTC
CGCCACATGGATCTAGAAAAAACACTAAAGATAATACTCCAGCAATTGTTCATATTGATTTAGTTCATGG
TGATAAAATTGAGGTTGATATTGCTGCAAAAGGTGGTGGATCTGAATTTAAATCAAAATTTAAGGTGTTA
AATCCTAGTGATAGCATAATTGATTGGGTTGAAGAGATGTTGCCAACTATGGGGGTTGGCTGGTGTCCAC
CTGGAATTATTGGTATAGGTATTGGAGGCACTGCAGAAAAAGCGATGCTTTTGGCTAAGGAATCTCTTAG
TGAAGAGATTAATATCCAAGATATTATCAAAAATGGCCCACAAAATGAAACAGAGCAACTAAGATTAGAT
ATCTATAATCGTGTCAATGCTCTGGGTATAGGTGCACAAGGCTTAGGTGGTTTGACAACAGTTTTAGATG
TCAAAATAAATGAATATCCAACCCATGCTGCGTGTAAGCCAGTTGCTTTGATTCCTAACTGTGCAGCTAC
TCGCCATGTTCATTTTGTTTTAGATGGTTCTGGTGCCGTTGATTTACCAGCTCCTAAGATAGAAGACTGG
CCAGTAATTGAGCAAGCACAAAATGATGATGTTAAGAGAATAAATCTTGATACAGTTACTAGAGAAGAGA
TTGAGGCATTAAGGTCGGGAGATAACGTTTTGATTAGCGGTAAAATCTTAACTGGTCGAGATGCTGCACA
TAAGCGTCTACAAGATATGTATAATGCTGGAGAAGATTTTCCTGTTGATCTTAACGGTAGATTTATCTAC
TACGTAGGTCCTGTTGATCCAGTAGGTGATGAGGTGGTTGGTCCAGCTGGTCCAACTACTGCTACGCGTA
TGGATAAGTTTACGCCATTTATGTTAGAGAAAGCTGGTATCATGGGAATGATAGGTAAATCAGAGCGTGG
TCAGGCAACGATTGATTCTATCAAGAAAAATAAAGCTATTTACTTCATGGGTGTAGGTGGTGCTGCTTAT
CTCATGTCTAAATCTATCAAAAAAGCAGAAGTTGTTGCATTTGAAGATCTTGGTATGGAGGCAATTTATG
AGTTTGAGGTTGAGGATATGCCAGTAACTGTGGCTGTTGACTCTTTAGGTGTTTCTGCTCATCAGCAAGG
TCCTAAACTTTGGAAACAAAAAATAGCTGAAATTAATAAGGTCTA
Protein Sequence 
>gi|89255932|ref|YP_513294.1| fumerate hydratase [Francisella tularensis subsp. holarctica LVS] MAVIKAEDLVNSVAEALQYISYYHPKDFIDAMYEAYQREESKPAKDAMVQILINSRMSAIGKRPICQDTGMVCAFVKVGMDAKLDKTDRTITELINEGVRRGYNDPYNPLRASMVFPPHGSRKNTKDNTPAIVHIDLVHGDKIEVDIAAKGGGSEFKSKFKVLNPSDSIIDWVEEMLPTMGVGWCPPGIIGIGIGGTAEKAMLLAKESLSEEINIQDIIKNGPQNETEQLRLDIYNRVNALGIGAQGLGGLTTVLDVKINEYPTHAACKPVALIPNCAATRHVHFVLDGSGAVDLPAPKIEDWPVIEQAQNDDVKRINLDTVTREEIEALRSGDNVLISGKILTGRDAAHKRLQDMYNAGEDFPVDLNGRFIYYVGPVDPVGDEVVGPAGPTTATRMDKFTPFMLEKAGIMGMIGKSERGQATIDSIKKNKAIYFMGVGGAAYLMSKSIKKAEVVAFEDLGMEAIYEFEVEDMPVTVAVDSLGVSAHQQGPKLWKQKIAEINKV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a FTL_0525 mutant was attenuated for infection in a mouse lung (Su et al., 2007)
COG COG1951C, under C: Energy production and conversion
References
Su et al., 2007: Su J, Yang J, Zhao D, Kawula TH, Banas JA, Zhang JR. Genome-wide identification of Francisella tularensis virulence determinants. Infection and immunity. 2007; 75(6); 3089-3101. [PubMed: 17420240].