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VAD1

Victor ID 4770
Gene Name VAD1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii
NCBI Protein GI 74656036
Other Database IDs CDD:185609
CDD:28928
CDD:28960
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name ATP-dependent RNA helicase VAD1
Protein Length 616
Protein Note Virulence-associated DEAD box protein 1
Protein Sequence 
>gi|74656036|sp|Q58Z64.1|DHH1_CRYNV RecName: Full=ATP-dependent RNA helicase VAD1; AltName: Full=Virulence-associated DEAD box protein 1
MASSSTLANDDWKQGLAAPPKDLRPQTEDVTATQGSRFEDFGLRRELLMGIYTAGFERPSPIQEQAIPMA
LTGRDILARAKNGTGKTASFIIPTLNRINTSLSHIQALILVPTRELALQTSQVCKTLGAHIPNLQVMITT
GGTTLRDDILRLQQPVHILVGTPGRILDLGSKGIAGLNKCGIFVMDEADKLLSEDFMPVIEQTLALCPQE
RQVMLFSATFPWTVKEFKDQHMVQPYEINLMDELTLKGVTQYYAYVEESQKVHCLNTLFSKLQINQSIIF
CNSTNRVELLAKKVTELGYSCFYSHAKMQQAHRNRVFHDFRNGMTRNLVCSDLLTRGIDIQAVNVVINFD
FPRTAESYLHRIGRSGRFGHLGLAISLLTLEDRHNLYRIESELGTEIAPIPAVIDPVLYVAPAMVEEERE
SPPPKPAAIAAPPAQQQPQQRQRQHPPVPSHQVAHHSPAAAPIQQQQQQQQQQQQPQYQLAYGQGPPQPQ
VPFQQANSSPAPAPLPSYPQQAPTQAQGPAQMQSPPSEPATQPQASAQIPVQGQTPPIQPRAQQQGQQQP
SQPGQAEGQSQPNRRPNTGGFRGNGRGQGHRGRGRGRGGQPGHPGAGASQSQQAQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: vad1 mutant is attenuated in mice (Panepinto et al., 2005).
References
Panepinto et al., 2005: Panepinto J, Liu L, Ramos J, Zhu X, Valyi-Nagy T, Eksi S, Fu J, Jaffe HA, Wickes B, Williamson PR. The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans. The Journal of clinical investigation. 2005; 115(3); 632-641. [PubMed: 15765146].