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Tco1

Victor ID 4766
Gene Name Tco1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Nucleotide GI 88707339
NCBI Protein GI 88707340
Protein Accession ABD49452.1
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name two-component-like hybrid sensor histidine kinase 1
Protein Note two-component-like protein 1
DNA Sequence 
>gi|88707339|gb|DQ383469.1| Cryptococcus neoformans var. grubii two-component-like hybrid sensor histidine kinase 1 (Tco1) gene, complete cds
GTGGGTCGCCACTCATCTCGTTGCAAAGACGAAACTCCCCGGCTTTCGTCAGCGCAGCTTTTGCGATGGC
GGCCGCTCTTTCGTCTTTGCCACACCTCTTGCCGTCCCGTGTCCCCCAATCAAAGCTGACATATCCCTTT
AGACTCGTTGCCCCTGCTGTACTTCTCCCCGCCCCTTCCGCACACACCCACCATCACCGACCGATCTCCT
CCCCACAAACGGGCAAGGTTGGCCGCCATGTCCCTCCCCGATGCCTACCCTCCGGTCATAGCCACCGAGG
GGAGCACGGCGTTCCAGTCGCACATTCTGTCCCTCTTGTCAGTGATATCCCAACATCCATCTCCCGATTA
TCCATTCCCAACGAGTGGCGATTCCACTCTGCAAGACAACGCTTCTGTGGCGGCAAAAAAGAGTGCTACC
CTTTCAACCTTTCCCGGCAAAAAGACCCCCGCTGAGGATGCGATTGAGCGAGCTATCATTGCTCTCGGTG
ATCGCGTTTGGACTTCTGAGAGGACTCAGGCGCATCTGGTAAAGGACACCAAACGCGACGTTCCTGCCCA
ACCTGGTTCAGATCTGCTTACTCCTGATTGGACTCCTCCAGTCCCCACCCTCAGCGACTCCTCTCCCGAT
CCTGTTTGTCCTACCTGTGCCCGGCCCGTTTCTTCCACCGAAAGCTCTTCCTTCACTCCGCAGCAGATTG
CATCTTTCTATCATCCTTTTACGGCTGCCCTGTCAACACCACCGCCTCCTCTCCCCGAACAAATGTTCTT
CCCACAGAGTGTTCTTGCTGCTTATGTCTCTGCTACTTCCGACAGCGAATCAGCTGGCGATTCTGGCATG
TCTGCCGAAAAGGAACTTGAACTTCTCAAAGCTCAAGTTCAGGACATCGCCCGTGTGTGTAAAGCTGTCG
CCACTGGTGATCTTACTCAGAAGATTATTGTACCCGTTAAAGGTCAGACCATGACTGAACTCAAAAACAT
CATTAATGCAATGGTGGATCGTCTGCAAACTTTTGCCGTGGAAGTCGAGCGTGTGTCTTTGGAAGTTGGT
ACTGAAGGAAAGCTCGGTGGACAGGCCGTCGTACCCAATGTCGAAGGCACGTGGAAGGTTCTCACCGCTG
TTGTGAACAAACTTGCCGCCAATTTGACTAACCAAGTGCGAAGCATCGCAAAAGTCACGAAAGCCGTAGC
AAAGGGTGATTTATCGGAAACCATCGACGTGGAGGCGAGTGGTGAAATTGCAGAATTAAAGACTACAGTC
AATGGAATGGTCATGTCTCTCAGAACATTGGCAGACGAGGTCAGCAGGGTGTCTTTGGAAGTCGGTAGTC
AAGGAAAGCTGGGAGGTCAAGCCAATGTGCCGGATGTGGAGGGAGTATGGAAAGATCTAACTGTCAATGT
AAGCAGGCCCCAATATAACAAGGCATCATTGACACTATGCAGGTGAATCGAATGTGTGAAAGTTTAACGA
CGCAAGTGCGATCAATCGGCAGTGTTACCACAGCCGTTGCTAGAGTCAGTATTTCCCTTTTTCTGCTTTA
ATCGCACTAATACTTTCTATCTAGGGTGACTTAAGCAAGATGATTGAGATTGAAGCAGAGGGAGAAATGG
CCGTCTTGAAGAATGTAGGTAAAAAATCATACTAAGATGAGTATGCTTCTAATCGCACTTATCATTATAG
ACCGTCAATTCAATGGTTCGGCAACTAACTGTATTCGCCAAAGAAGTGACTCGAGTTGCGTTAGAGGTCG
GTACCCATGGCCAGCTGGGCGGTCAAGCCGTCGTTCCCGGCGTTGAAGGCGTATGGGACGATCTTACAAC
CAATGTCAACAAGATGGCCAGGAATTTGACAGATCAAGTGCGGGAGATTGCCATGGTCGTAAGCTGATCG
AAACATTTATAAGATAGTAGATTAACATCTCTTCTTGCAGACAAAAGCTGTCGCTCGGGGTGACTTATCC
AAGACAGTCAATGCCGACGTACAAGGTGAAATTCTTGACTTGAAGTGTACTGTCAATGAAATGGTGAGTA
CGGATTACAGAAACCTTCAAACACAAAAGCTTACCAACGTGCCATGTAAGGTTGCCCAACTGACAGTATT
CGCTGCCGAGGTTACTCGTGTATCTCTTGAAGTTGGAACAGAGGGGAAATTGGGTGGACAAGCTGTCGTG
CCGAACGTGGAAGGCACTTGGATGGTCCTTACGGACAATGTTAACCTAATGGTATGGCTATTTCACTGGC
ATTACATGATGATCTTGATATCTTATGCGCACATAGGCCCTAAACTTGACTACTCAAGTGCGTTCCGTTG
CTGAAGTGTAGGTGTTCGTGATTCAGAGGAAGGCATCAGCTTACTCCGTCTCTGCAGTACAACGGCCGTC
GCTGCTGGTGATCTTAGCAAGAAAATTAACGTCGCCGCGTTCGGCGAAATCCTCGAGCTTAAAAACACTG
TCAATAACATGGTGGATTCTCTGCGTTCGTTCTCATCCGAAGTCACCCGTGTCGCGCGAGAAGTCGGAAC
CGATGGGCGACTAGGTGGTCAGGCCAAGGTTCCGGGAGTGGCCGGTACTTGGAAGGACTTGACAGATTGT
GTTAACATCATGGCGGCCAATTTGACTGAGCAGGTCCGAACCATCGCGCATGCCACTGTAAGTGTTCTTG
AACCCAATTAGCCTTTGCGACTGCTGACCAACTTGTCAGACTGCAGTAGCTCGTGGTGATTTGACTCAAA
AGGTTGTCGGCGTCAAAGTATCTGGAGAGATCCTTGATCTGGTGAATACGATCAATAATATGATTGACCA
ATTAGCTATATTCGCGGCAGAAGTGACGCGTGTCGCTAGGGAAGTTGGTACAGAGGGAAAGTTAGGAGTG
CAGGCCGAAGTTGAAAACATTGAAGGAACCTGGCAAGAGATCACGTAAGGCGTCACCTTTACTTCCAGTC
AAGCGCGTAATTGACTTGTTTCGCAGATCCAACGTGAACACCATGGCCTCAAACCTGACATCCCAAGTTC
GAGCCTTTGCTCAAATTTCCGCCGCTGCAACAGATGGTGACTTCACAAGGTTCATCACTGTTGAAGCGTC
TGGTGAAATGGATAGCCTAAAAACGAAGATTAATCAGATGGTGTACAATCTCAGAGAGTCCATCGAGAAA
AACACCAAGGCGAGACAGGAAGCTGAAATGGCCAACAGAAGTAAATCCGAGTTTTTGGCCAATATGTCCC
ATGAAATCCGGACGCCAATGAACGGTATTATCGGTATGACAGTATTGACACTGGAGAGCGAGTTGACTAG
GCAACAACGAGAGAATTTGATGATTGTCTCCAGTTTGGCCGGATCCCTGTTAACTATCATCGACGATATC
CTCGATATTTCTAAGAGTGAGTGAGAGTGTGCTGAACATCAATGTGAATATAATGCTGATTTGATGCATA
GTTGAGGCGGGCCGCATGACCATGGAACAAATCCCCTTCTCCTTACGTGTAGCCGTCTTCTCGGTCCTCA
AAACCCTATGTGTTAAGGCAGCCCAGAATAAGCTGGATCTCATCTTTGACGTTGATCCCACGATGCCTGA
TCAACTTATTGGTGATCCACTTCGTCTTCGCCAAGTCATTACCAACCTCATCGGTAACGCTGTGAAGTTC
ACTACCAAAGGTCAAGTTGCTCTTTCTTGCCGAGTCAAACGCTACGTTGCTGTCGCCGACGCTGTTGAGC
TTGAATTCTGCGTGGCAGACACTGGTATCGGTATCAAGCAGGATAAGCTTGATGTCATCTTTGACACCTT
CGCGCAAGCGGATGGATCTACCACTCGCAAGTACGGTGGGACTGGCCTGGGATTGACCATCTCCAAACGA
CTTGTGAACCTGATGAGTGGTGACCTTTGGGTTGAGTCAGAATATGGGCAGGGAAGTAGATTCTATTTCA
CTACTGTTGCAGAGATGACCAGCGTGCCGAGGGATCAAATAATAGAACGGCTATCGCCTTGGTCCGGCAG
AAGCGTGTTGTTTATTGACACACTTGGTGATCAAACGGGAATCGTGGAAATGCTCCAAGAACTTGGTTTA
AAGCCTATCGTTATCCATTCTGTGAACGATGTGTACCTTTTACAGGATCAAGGCTTGACTGTCTTTGACA
CCATGATCGTTGATTCTCTTAAAGCTGTGAGTCCGAGTCGTTCAAAGTGGTACAGTATTATTGATGTTAT
TTCCAGGCGGGAGAACTGAGAGGCATAGAATATCTTCGCTACATCCCCATTGTTCTCCTTGCACCATCGA
ACAAACCAAGTGGACCTTCTAATCCATCTTTCATCTCACTTCCCGAATCCCGCCGCCGTCTTCTTGCCCT
TCCTTCCGCCTCCGAACAACTTCTCTCACCTATACCCGTCAAGGATTGCTTAGAAATGGGTATCAACACA
TACTATACCACCCCTCTCTCGTTACAAGAGTTATCCAACGCGATAGTCCCCGCGCTGGAATCTCATCAGA
TCCAACCAGGCGACACTGTTAGGGACACCATCCTCAGCGTGTTACTTGCGGAAGACAACCTAGTGAATCA
GAAACTGGCTGTTAAATTGATGGAGGTCGCTGGTCATAAGATTGAAGTTGCAGACAATGGTGAAATTGCG
TTAGAAAAGTACAAGAGGCGACAGCTGGCTAGAACGCCATTTGACGTCATTCTGGTGAGTCGTTGATAGC
TTGTAAATCTATATTCTGACTGACCAAAATGATTAGATGGATGTTTCAATGCCTGTGATGGGAGGCATGG
AAGCCACGGGTCTGATTCGCGAGTTTGAAGCGAATGAGGGCGTACCTCGCACACCTATTATCGCTCTTAC
GGCCCACGCGATGATCGGTGACAAGGAGAGATGTCTTGCGGCTGGCATGGACGAATACGTCACGAAGCCT
CTGAGGAGAGGCGATTTATTGGCATCAATAGCCAAAGTATTAGCTCCCAAGCAGTCTGCCAGCGGCTTGG
AAATGCCGGCCGTATCTATTCCCGCAAATATCTATGGTAGATAACCCTTCTCTCGTTCGCCCGATTGTCG
ACCTCCATTCGAGATTATCTCGTCAATATCTCATACCCTATTCAACTAGATGACGGCCTCCATGCTGTCG
CATCGCAATGTTTATACCCCTTCTAGCCCCTCATTTTCCTTTCAAAATGTTTCCTTTTATTTTATTCTGC
TTTCTTTCTAGGTTTATTCGCTAAACACACCCTCTAAACGTTACCACAGAGGTGTACCTCGGATTGCTTG
GAATCTTGGGTTGTCTATGTACCACTTTTGGGTCTCG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tco1 mutant is attenuated in mice (Bahn et al., 2006).
References
Bahn et al., 2006: Bahn YS, Kojima K, Cox GM, Heitman J. A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Molecular biology of the cell. 2006; 17(7); 3122-3135. [PubMed: 16672377].