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Pkr1

Victor ID 4760
Gene Name Pkr1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. neoformans JEC 21
NCBI Protein GI 21667390
Other Database IDs CDD:141548
CDD:28920
Taxonomy ID 40410
Gene Strand (Orientation) ?
Protein Name cAMP-dependent protein kinase regulatory subunit
Protein Length 482
Protein Note teleomorph: Filobasidiella neoformans var. neoformans
Protein Sequence 
>gi|21667390|gb|AAM74046.1|AF481771_1 cAMP-dependent protein kinase regulatory subunit [Cryptococcus neoformans var. neoformans]
MSSWTDILNDLNRDIALDNPTDILQWGADWFQHKLRQERQNSNASTRQAHPGTLAFNATNFGSLPPHTLS
PFSEMGPSDSPFGPTARRATVPTESNLSVQPLFSTPFSASSGVLRTDDRSPFSEGGGMPFGNSPFGEKSQ
SHGAQDDPPVPSYALGRRTSVSAESLVPTSQRAYGPTSGLETTMEEDENTHNLSSGTPVFPKSEEQLARI
RQAIKPNFLFRNLDDEQEADVLAAMKEVKMDAGEVVIEQGAAGDFFYIVENGRLDVFVNKEGQVLDLEKG
DRQGLGKKVAECSEGSSFGELALMHNAPRAASIISLTPCTLWALDRVSFRTILLDHTSRKRRLYESFLSE
VPILASLQPQERAKIADVLESRTYNEGEDVIRQGDAGDEFFLIESGNAMAIKTDEDGNQSVVKHLGQGEY
FGELALLNRRTRAATIRAEGPDKLRVAALGEQAFTRLLGPVKDIMARSVSERYGFSTGRGSM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Pkr1 mutant is avirulent in mice (Hicks et al., 2004).
References
Hicks et al., 2004: Hicks JK, D'Souza CA, Cox GM, Heitman J. Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryotic cell. 2004; 3(1); 14-26. [PubMed: 14871933].