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PKA1

Victor ID 4759
Gene Name PKA1
Sequence Strain (Species/Organism) Cryptococcus neoformans var. grubii H99
NCBI Protein GI 11096026
Other Database IDs CDD:140289
CDD:173671
Taxonomy ID 178876
Gene Strand (Orientation) ?
Protein Name cAMP dependent protein kinase catalytic subunit
Protein Length 515
Protein Note protein kinase A catalytic subunit; Provisional
Protein Sequence 
>gi|11096026|gb|AAG30145.1|AF288613_1 cAMP dependent protein kinase catalytic subunit [Cryptococcus neoformans var. grubii]
MFQKVSDKFHRKQQSSTSPGKTQQVPNSPSSVLAKANSQAQQAYSSQDHSPMEGIQSDSTHIQQPMATQK
APIVGPSTSTSLSTVPVQDGTLPLTPGAQGMLAGTTDGHRQVQSPVSRSSSAGEDKMREKARDAQEQAAQ
AQANLHRVTQQARVAAINAAATQAALETATQLPATARVPTSGTGAEPGQARRKTAGRYALSDFLIERTLG
TGSFGRVHLVRSRHNGRFYAVKVLNKEKVIKMKQVEHTNSEREMLVRVRHPFLVNLWGTFQDVNNLYMVM
DFVAGGELFSLLRKSQRFPNSVAKFYAAEVALALDYLHSLDIIYRDLKPENLLLGADGHVKVTDFGFAKY
VPDITWTLCGTPDYLAPEVVQSKGYNKSVDWYALGVLIFEMLAGYPPFFTEDGNPMKLYEKIIAGKVRYP
TYFDVLAKELLKNLLIGDLTKRYGNLRAGSSDIFAHGWFAEVDWDKLYRREIPAPYVPKIDGEGDASQFD
RYQEADVSAYGKVGNGPYDHFFVEF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pka1 mutant is avirulent in mice and rabbits (D'Souza et al., 2001).
References
D'Souza et al., 2001: D'Souza CA, Alspaugh JA, Yue C, Harashima T, Cox GM, Perfect JR, Heitman J. Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Molecular and cellular biology. 2001; 21(9); 3179-3191. [PubMed: 11287622].